FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890569433> ?p ?o ?g. }

• W2890569433 endingPage "51" @default.
• W2890569433 startingPage "43" @default.
• W2890569433 abstract "Orosomucoid like-3 (ORMDL3) has been identified to be associated with the development of asthma according to previous studies. However, the definite role of ORMDL3 in the pathogenesis of asthma remains unclear. In this study, we found ORMDL3 was highly expressed in PBMC specimens from childhood asthma patients. Cytokines production and p-ERK/MMP-9 pathway expression was also increased in childhood asthma patients compared with controls. In addition, ORMDL3 overexpression induced IL-6 and IL-8 release and activated p-ERK/MMP-9 pathway in vitro. Increased ORMDL3 expression was observed after treated with 5-Aza-CdR. 5-Aza-CdR decreased the percentage of the CpG island in the ORMDL3 promoter region and increased its promoter activity. In addition, 5-Aza-CdR significantly increased IL-6 and IL-8 levels in NHBE cells while there was no obvious alteration after knocking down ORMDL3. Knockdown of ORMDL3 also significantly decreased the expression of p-ERK/MMP-9 pathway in the presence or absence of 5-Aza-CdR. In conclusion, our study provided novel evidence for the association between ORMDL3 and asthma-associated cytokines. Moreover, DNA methylation plays an important role in ORMDL3-mediated increased IL-6 and IL-8 levels and p-ERK/MMP-9 pathway expression." @default.
• W2890569433 created "2018-09-27" @default.
• W2890569433 creator A5001154983 @default.
• W2890569433 creator A5017960969 @default.
• W2890569433 creator A5020478633 @default.
• W2890569433 creator A5025100608 @default.
• W2890569433 creator A5026031878 @default.
• W2890569433 creator A5031725290 @default.
• W2890569433 creator A5062405040 @default.
• W2890569433 creator A5064924352 @default.
• W2890569433 creator A5068176076 @default.
• W2890569433 creator A5079144123 @default.
• W2890569433 creator A5079382582 @default.
• W2890569433 creator A5080359383 @default.
• W2890569433 date "2018-11-01" @default.
• W2890569433 modified "2023-10-13" @default.
• W2890569433 title "Methylation status of ORMDL3 regulates cytokine production and p-ERK/MMP9 pathway expression" @default.
• W2890569433 cites W1503744211 @default.
• W2890569433 cites W1976206459 @default.
• W2890569433 cites W1980252166 @default.
• W2890569433 cites W1983256356 @default.
• W2890569433 cites W2012568595 @default.
• W2890569433 cites W2037877578 @default.
• W2890569433 cites W2062163667 @default.
• W2890569433 cites W2079609402 @default.
• W2890569433 cites W2092889771 @default.
• W2890569433 cites W2098698887 @default.
• W2890569433 cites W2116575997 @default.
• W2890569433 cites W2119008404 @default.
• W2890569433 cites W2126835609 @default.
• W2890569433 cites W2128675289 @default.
• W2890569433 cites W2135431323 @default.
• W2890569433 cites W2135555439 @default.
• W2890569433 cites W2144712546 @default.
• W2890569433 cites W2148356965 @default.
• W2890569433 cites W2157521429 @default.
• W2890569433 cites W2163317648 @default.
• W2890569433 cites W2167058139 @default.
• W2890569433 cites W2183920120 @default.
• W2890569433 cites W2194063385 @default.
• W2890569433 cites W2522855402 @default.
• W2890569433 cites W2561808084 @default.
• W2890569433 cites W2585011132 @default.
• W2890569433 cites W2600653613 @default.
• W2890569433 cites W2738608879 @default.
• W2890569433 cites W2738676713 @default.
• W2890569433 cites W2744208468 @default.
• W2890569433 cites W2753577203 @default.
• W2890569433 cites W2756565115 @default.
• W2890569433 cites W2791342917 @default.
• W2890569433 doi "https://doi.org/10.1016/j.yexcr.2018.09.008" @default.
• W2890569433 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30217493" @default.
• W2890569433 hasPublicationYear "2018" @default.
• W2890569433 type Work @default.
• W2890569433 sameAs 2890569433 @default.
• W2890569433 citedByCount "9" @default.
• W2890569433 countsByYear W28905694332019 @default.
• W2890569433 countsByYear W28905694332020 @default.
• W2890569433 countsByYear W28905694332021 @default.
• W2890569433 countsByYear W28905694332022 @default.
• W2890569433 countsByYear W28905694332023 @default.
• W2890569433 crossrefType "journal-article" @default.
• W2890569433 hasAuthorship W2890569433A5001154983 @default.
• W2890569433 hasAuthorship W2890569433A5017960969 @default.
• W2890569433 hasAuthorship W2890569433A5020478633 @default.
• W2890569433 hasAuthorship W2890569433A5025100608 @default.
• W2890569433 hasAuthorship W2890569433A5026031878 @default.
• W2890569433 hasAuthorship W2890569433A5031725290 @default.
• W2890569433 hasAuthorship W2890569433A5062405040 @default.
• W2890569433 hasAuthorship W2890569433A5064924352 @default.
• W2890569433 hasAuthorship W2890569433A5068176076 @default.
• W2890569433 hasAuthorship W2890569433A5079144123 @default.
• W2890569433 hasAuthorship W2890569433A5079382582 @default.
• W2890569433 hasAuthorship W2890569433A5080359383 @default.
• W2890569433 hasBestOaLocation W28905694331 @default.
• W2890569433 hasConcept C104317684 @default.
• W2890569433 hasConcept C126322002 @default.
• W2890569433 hasConcept C150194340 @default.
• W2890569433 hasConcept C164007495 @default.
• W2890569433 hasConcept C173396325 @default.
• W2890569433 hasConcept C190283241 @default.
• W2890569433 hasConcept C190727270 @default.
• W2890569433 hasConcept C203014093 @default.
• W2890569433 hasConcept C2777468819 @default.
• W2890569433 hasConcept C2780942790 @default.
• W2890569433 hasConcept C33288867 @default.
• W2890569433 hasConcept C502942594 @default.
• W2890569433 hasConcept C515207424 @default.
• W2890569433 hasConcept C54355233 @default.
• W2890569433 hasConcept C57074206 @default.
• W2890569433 hasConcept C62478195 @default.
• W2890569433 hasConcept C71924100 @default.
• W2890569433 hasConcept C86803240 @default.
• W2890569433 hasConcept C95444343 @default.
• W2890569433 hasConceptScore W2890569433C104317684 @default.
• W2890569433 hasConceptScore W2890569433C126322002 @default.
• W2890569433 hasConceptScore W2890569433C150194340 @default.
• W2890569433 hasConceptScore W2890569433C164007495 @default.

• next