Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890571461> ?p ?o ?g. }
- W2890571461 endingPage "1476" @default.
- W2890571461 startingPage "1469" @default.
- W2890571461 abstract "Thioguanine is sensitive to UVA light and generates singlet molecular oxygen (1O2*) when exposed to UVA. Three thioguanosine derivatives, 2′,3′,5′-tri-O-acetyl-6-thioguanosine (ta6TGuo), 2′,3′,5′-tri-O-acetyl-8-thioguanosine (ta8TGuo), and 2′,3′,5′-tri-O-acetyl-6,8-dithioguanosine (taDTGuo) were explored photophysically and photochemically. Nanosecond transient absorption and time-resolved near-infrared emission measurements were carried out to investigate the characteristics of their excited triplet states in acetonitrile solution. The quantum yield of intersystem crossing (ΦISC), the intrinsic decay rate constant (k0), the quenching rate constant by 3O2 (kq) and the self-quenching rate constant (kSQ) of their triplet states were all determined. From the precise analysis of the quantum yield of 1O2* generation (ΦΔ) against the concentration of dissolved molecular oxygen, the fraction of the triplet states quenched by dissolved oxygen which gives rise to 1O2* formation (SΔ) was successfully obtained with high accuracy. The ΦΔ values at low oxygen concentrations reveal that these thioguanosines, particularly taDTGuo, can still effectively generate 1O2* at low molecular oxygen concentrations like carcinomatous microenvironments. These findings indicate that taDTGuo would perform well as a potential agent for photo-induced cancer therapies." @default.
- W2890571461 created "2018-09-27" @default.
- W2890571461 creator A5017266252 @default.
- W2890571461 creator A5025493198 @default.
- W2890571461 creator A5028358916 @default.
- W2890571461 creator A5041092558 @default.
- W2890571461 creator A5051170221 @default.
- W2890571461 date "2018-10-01" @default.
- W2890571461 modified "2023-10-18" @default.
- W2890571461 title "Characteristics of the excited triplet states of thiolated guanosine derivatives and singlet oxygen generation" @default.
- W2890571461 cites W1966242338 @default.
- W2890571461 cites W1966718405 @default.
- W2890571461 cites W1976645299 @default.
- W2890571461 cites W1982225862 @default.
- W2890571461 cites W2002091803 @default.
- W2890571461 cites W2008916603 @default.
- W2890571461 cites W2019556102 @default.
- W2890571461 cites W2020640998 @default.
- W2890571461 cites W2020678264 @default.
- W2890571461 cites W2028310515 @default.
- W2890571461 cites W2028358995 @default.
- W2890571461 cites W2030332530 @default.
- W2890571461 cites W2030879575 @default.
- W2890571461 cites W2032677352 @default.
- W2890571461 cites W2041293640 @default.
- W2890571461 cites W2045402205 @default.
- W2890571461 cites W2053242843 @default.
- W2890571461 cites W2062673672 @default.
- W2890571461 cites W2068920852 @default.
- W2890571461 cites W2071241433 @default.
- W2890571461 cites W2072173165 @default.
- W2890571461 cites W2072509880 @default.
- W2890571461 cites W2078979960 @default.
- W2890571461 cites W2083544305 @default.
- W2890571461 cites W2087624153 @default.
- W2890571461 cites W2087917300 @default.
- W2890571461 cites W2095522400 @default.
- W2890571461 cites W2104094507 @default.
- W2890571461 cites W2109779790 @default.
- W2890571461 cites W2114478931 @default.
- W2890571461 cites W2116165311 @default.
- W2890571461 cites W2119665774 @default.
- W2890571461 cites W2124955918 @default.
- W2890571461 cites W2127393068 @default.
- W2890571461 cites W2128659255 @default.
- W2890571461 cites W2135158270 @default.
- W2890571461 cites W2141506516 @default.
- W2890571461 cites W2158002184 @default.
- W2890571461 cites W2158671382 @default.
- W2890571461 cites W2158815442 @default.
- W2890571461 cites W2160548040 @default.
- W2890571461 cites W2165637637 @default.
- W2890571461 cites W2168310786 @default.
- W2890571461 cites W2178006639 @default.
- W2890571461 cites W2265452979 @default.
- W2890571461 cites W2326045423 @default.
- W2890571461 cites W2326353536 @default.
- W2890571461 cites W2592254509 @default.
- W2890571461 cites W2608394191 @default.
- W2890571461 cites W2626881922 @default.
- W2890571461 cites W2731934791 @default.
- W2890571461 cites W2785523385 @default.
- W2890571461 cites W2786521284 @default.
- W2890571461 cites W2791536089 @default.
- W2890571461 cites W98231071 @default.
- W2890571461 doi "https://doi.org/10.1039/c8pp00240a" @default.
- W2890571461 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30280174" @default.
- W2890571461 hasPublicationYear "2018" @default.
- W2890571461 type Work @default.
- W2890571461 sameAs 2890571461 @default.
- W2890571461 citedByCount "4" @default.
- W2890571461 countsByYear W28905714612019 @default.
- W2890571461 countsByYear W28905714612020 @default.
- W2890571461 countsByYear W28905714612022 @default.
- W2890571461 crossrefType "journal-article" @default.
- W2890571461 hasAuthorship W2890571461A5017266252 @default.
- W2890571461 hasAuthorship W2890571461A5025493198 @default.
- W2890571461 hasAuthorship W2890571461A5028358916 @default.
- W2890571461 hasAuthorship W2890571461A5041092558 @default.
- W2890571461 hasAuthorship W2890571461A5051170221 @default.
- W2890571461 hasBestOaLocation W28905714611 @default.
- W2890571461 hasConcept C120665830 @default.
- W2890571461 hasConcept C121332964 @default.
- W2890571461 hasConcept C121745418 @default.
- W2890571461 hasConcept C134121241 @default.
- W2890571461 hasConcept C148898269 @default.
- W2890571461 hasConcept C161522054 @default.
- W2890571461 hasConcept C171001562 @default.
- W2890571461 hasConcept C178790620 @default.
- W2890571461 hasConcept C181500209 @default.
- W2890571461 hasConcept C184779094 @default.
- W2890571461 hasConcept C185592680 @default.
- W2890571461 hasConcept C191897082 @default.
- W2890571461 hasConcept C192562407 @default.
- W2890571461 hasConcept C2777463227 @default.
- W2890571461 hasConcept C2777516457 @default.
- W2890571461 hasConcept C32909587 @default.
- W2890571461 hasConcept C33062035 @default.