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• W2890572624 abstract "Bacterial challenge of keratinocytes with the abundant skin commensal <i>Staphylococcus epidermidis</i> induces distinct innate immune responses, but the underlying molecular mechanisms are still emerging. We report that the aryl hydrocarbon receptor (AhR) was activated in human primary keratinocytes infected with <i>S. epidermidis</i>, leading to induction of the AhR-responsive gene cytochrome P450 1A1 (CYP1A1). In addition, functional AhR was required for <i>S. epidermidis</i>-mediated induction of IL-1β expression in keratinocytes. AhR-dependent gene induction of IL-1β and CYP1A1 was mediated by factor(s) &#x3c; 2 kDa secreted by <i>S. epidermidis</i>. Blockade of the AhR in a 3D organotypic skin equivalent infected with <i>S. epidermidis</i> attenuated the <i>S. epidermidis</i>-induced CYP1A1 and IL-1β expression. Moreover, <i>S. epidermidis</i> also induced expression of IL-1α and of the antimicrobial peptide human β-defensin-3 in an AhR-dependent manner in a 3D skin equivalent. An increased outgrowth of <i>S. epidermidis</i> on the surface of skin explants treated with a specific AhR inhibitor further indicate a pivotal role of the AhR in mediating an epidermal defense response. Taken together, our data expand the role of the AhR in innate immunity and support a previously unappreciated contribution for the AhR in cutaneous defense." @default.
• W2890572624 created "2018-09-27" @default.
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• W2890572624 date "2018-09-03" @default.
• W2890572624 modified "2023-10-18" @default.
• W2890572624 title "<b><i>Staphylococcus epidermidis</i></b> Activates Aryl Hydrocarbon Receptor Signaling in Human Keratinocytes: Implications for Cutaneous Defense" @default.
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• W2890572624 doi "https://doi.org/10.1159/000492162" @default.
• W2890572624 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6738203" @default.
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• W2890572624 hasPublicationYear "2018" @default.
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