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• W2890573955 abstract "Prokaryotic genomes show a high level of information compaction often with different molecules transcribed from the same locus. Although antisense RNAs have been relatively well studied, RNAs in the same strand, internal RNAs (intraRNAs), are still poorly understood. The question of how common is the translation of overlapping reading frames remains open. We address this question in the model archaeon Halobacterium salinarum. In the present work we used differential RNA-seq (dRNA-seq) in H. salinarum NRC-1 to locate intraRNA signals in subsets of internal transcription start sites (iTSS) and establish the open reading frames associated to them (intraORFs). Using C-terminally flagged proteins, we experimentally observed isoforms accurately predicted by intraRNA translation for kef1, acs3 and orc4 genes. We also recovered from the literature and mass spectrometry databases several instances of protein isoforms consistent with intraRNA translation such as the gas vesicle protein gene gvpC1. We found evidence for intraRNAs in horizontally transferred genes such as the chaperone dnaK and the aerobic respiration related cydA in both H. salinarum and Escherichia coli. Also, intraRNA translation evidence in H. salinarum, E. coli and yeast of a universal elongation factor (aEF-2, fusA and eEF-2) suggests that this is an ancient phenomenon present in all domains of life." @default.
• W2890573955 created "2018-09-27" @default.
• W2890573955 creator A5009074574 @default.
• W2890573955 creator A5010317899 @default.
• W2890573955 creator A5034746983 @default.
• W2890573955 creator A5081206216 @default.
• W2890573955 creator A5085680257 @default.
• W2890573955 creator A5088294160 @default.
• W2890573955 date "2018-09-19" @default.
• W2890573955 modified "2023-09-26" @default.
• W2890573955 title "Internal RNAs overlapping coding sequences can drive the production of alternative proteins in archaea" @default.
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