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- W2890574054 abstract "The oral mucosa is vascularized where by absorbed drugs get direct access to the systemic circulation without first pass metabolism. This present work is to formulate mouth dissolving film of Ezetamibe for enhanced bioavalibility. Drug and excipients studies were conducted using FTIR. Oral films of Ezetamibe were formulated using HPMC E5, as a film forming agent and propylene glycol as plasticize. And citricacid (salaviry stimulent), flavouring agents (vennila) are used.The solvent casting method was used for the preparation of films. Ezetamibe oral film was evaluated for folding endurance, thickness, weight variation test, surface pH, content uniformity,dissolving time and in-vitro dissolution. No drug–excipients interaction was observed. The characterization studies depict the purity of drug and all the excipients used in the formulation. The IR spectrum of mixture of Ezetamibe with all other excipients does not show any changes which indicate its compatibility with other excipients. From the results, it can be concluded that the fast dissolving oral film of Ezetamibe showed fast disintegration, dissolution of drug in salivary pH. Thus the prepared fast dissolving films of Ezetamibe could be a better alternative for achieving rapid oral bio availability. Keywords: Ezetamibe, hypercholesterolaemia,HPMC," @default.
- W2890574054 created "2018-09-27" @default.
- W2890574054 creator A5022678452 @default.
- W2890574054 date "2018-01-01" @default.
- W2890574054 modified "2023-09-26" @default.
- W2890574054 title "Formulation And In-Vitro Evaluation Of Oral Fast Dissolving Strips By Using Ezetamibe As A Model Drug" @default.
- W2890574054 doi "https://doi.org/10.5281/zenodo.1135421" @default.
- W2890574054 hasPublicationYear "2018" @default.
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