Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890580102> ?p ?o ?g. }
- W2890580102 abstract "Abstract There are 20-50 functionally- and anatomically-distinct ganglion cell types in the mammalian retina; each type encodes a unique feature of the visual world and conveys it via action potentials to the brain. Individual ganglion cells receive input from unique presynaptic retinal circuits, and the characteristic patterns of light-evoked action potentials in each ganglion cell type therefore reflect computations encoded in synaptic input and in postsynaptic signal integration and spike generation. Unfortunately, there is a dearth of tools for characterizing retinal ganglion cell computation. Therefore, we developed a statistical model, the separable Nonlinear Input Model, capable of characterizing the large array of distinct computations reflected in retinal ganglion cell spiking. We recorded ganglion cell responses to a correlated noise (“cloud”) stimulus designed to accentuate the important features of retinal processing in an in vitro preparation of mouse retina and found that this model accurately predicted ganglion cell responses at high spatiotemporal resolution. It identified multiple receptive fields (RFs) reflecting the main excitatory and suppressive components of the response of each neuron. Most significantly, our model succeeds where others fail, accurately identifying ON-OFF cells and segregating their distinct ON and OFF selectivity and demonstrating the presence of different types of suppressive receptive fields. In total, our computational approach offers rich description of ganglion cell computation and sets a foundation for relating retinal computation to retinal circuitry." @default.
- W2890580102 created "2018-09-27" @default.
- W2890580102 creator A5001438490 @default.
- W2890580102 creator A5011265988 @default.
- W2890580102 creator A5011748503 @default.
- W2890580102 creator A5020406825 @default.
- W2890580102 creator A5035810078 @default.
- W2890580102 date "2018-09-18" @default.
- W2890580102 modified "2023-09-29" @default.
- W2890580102 title "Functional characterization of retinal ganglion cells using tailored nonlinear modeling" @default.
- W2890580102 cites W124726370 @default.
- W2890580102 cites W1522488279 @default.
- W2890580102 cites W1694767778 @default.
- W2890580102 cites W1838160292 @default.
- W2890580102 cites W1885047945 @default.
- W2890580102 cites W1898957235 @default.
- W2890580102 cites W1911130548 @default.
- W2890580102 cites W1966638248 @default.
- W2890580102 cites W1970546757 @default.
- W2890580102 cites W1975003449 @default.
- W2890580102 cites W1979275115 @default.
- W2890580102 cites W1989786687 @default.
- W2890580102 cites W2008624261 @default.
- W2890580102 cites W2010607259 @default.
- W2890580102 cites W2012189712 @default.
- W2890580102 cites W2014461681 @default.
- W2890580102 cites W2016397514 @default.
- W2890580102 cites W2018243434 @default.
- W2890580102 cites W2018837082 @default.
- W2890580102 cites W2022186938 @default.
- W2890580102 cites W2034387541 @default.
- W2890580102 cites W2035853180 @default.
- W2890580102 cites W2036643343 @default.
- W2890580102 cites W2037084455 @default.
- W2890580102 cites W2039251595 @default.
- W2890580102 cites W2051526952 @default.
- W2890580102 cites W2056356727 @default.
- W2890580102 cites W2058483899 @default.
- W2890580102 cites W2063861811 @default.
- W2890580102 cites W2065176644 @default.
- W2890580102 cites W2065621419 @default.
- W2890580102 cites W2073326835 @default.
- W2890580102 cites W2074041755 @default.
- W2890580102 cites W2076225732 @default.
- W2890580102 cites W2077229035 @default.
- W2890580102 cites W2081066886 @default.
- W2890580102 cites W2086186401 @default.
- W2890580102 cites W2089338590 @default.
- W2890580102 cites W2094561611 @default.
- W2890580102 cites W2099468530 @default.
- W2890580102 cites W2112246597 @default.
- W2890580102 cites W2112455917 @default.
- W2890580102 cites W2114185957 @default.
- W2890580102 cites W2114744983 @default.
- W2890580102 cites W2116166332 @default.
- W2890580102 cites W2119610790 @default.
- W2890580102 cites W2121289914 @default.
- W2890580102 cites W2125277430 @default.
- W2890580102 cites W2127388521 @default.
- W2890580102 cites W2129983824 @default.
- W2890580102 cites W2139979304 @default.
- W2890580102 cites W2154150265 @default.
- W2890580102 cites W2155443738 @default.
- W2890580102 cites W2159198041 @default.
- W2890580102 cites W2160032358 @default.
- W2890580102 cites W2162901954 @default.
- W2890580102 cites W2164414836 @default.
- W2890580102 cites W2165362195 @default.
- W2890580102 cites W2167314716 @default.
- W2890580102 cites W2169924703 @default.
- W2890580102 cites W2171525519 @default.
- W2890580102 cites W2174781702 @default.
- W2890580102 cites W2213191115 @default.
- W2890580102 cites W2265398297 @default.
- W2890580102 cites W2325920429 @default.
- W2890580102 cites W2405071104 @default.
- W2890580102 cites W2473110711 @default.
- W2890580102 cites W2736874493 @default.
- W2890580102 cites W2951565738 @default.
- W2890580102 cites W3106387966 @default.
- W2890580102 cites W68224751 @default.
- W2890580102 doi "https://doi.org/10.1101/421396" @default.
- W2890580102 hasPublicationYear "2018" @default.
- W2890580102 type Work @default.
- W2890580102 sameAs 2890580102 @default.
- W2890580102 citedByCount "0" @default.
- W2890580102 crossrefType "posted-content" @default.
- W2890580102 hasAuthorship W2890580102A5001438490 @default.
- W2890580102 hasAuthorship W2890580102A5011265988 @default.
- W2890580102 hasAuthorship W2890580102A5011748503 @default.
- W2890580102 hasAuthorship W2890580102A5020406825 @default.
- W2890580102 hasAuthorship W2890580102A5035810078 @default.
- W2890580102 hasBestOaLocation W28905801021 @default.
- W2890580102 hasConcept C133529732 @default.
- W2890580102 hasConcept C15744967 @default.
- W2890580102 hasConcept C169760540 @default.
- W2890580102 hasConcept C170493617 @default.
- W2890580102 hasConcept C19071747 @default.
- W2890580102 hasConcept C197341189 @default.
- W2890580102 hasConcept C2777093970 @default.