Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890580771> ?p ?o ?g. }
- W2890580771 endingPage "333" @default.
- W2890580771 startingPage "324" @default.
- W2890580771 abstract "Diabetic retinopathy (DR) is a severe sight-threatening complication of diabetes. It causes progressive damage to the retina and is the most common cause of vision impairment and blindness among diabetic patients. DR develops as a result of various changes in the ocular environment. Such changes include accelerated mitochondrial dysfunction, apoptosis, reactive oxygen species production, and formation of acellular capillaries. Matrix metalloproteinases (MMPs) are one of the major culprits in causing DR. Under physiological conditions, MMPs cause remodeling of the extracellular matrix in the retina, while under pathological conditions, they induce retinal cell apoptosis. This review focuses on the roles of various MMPs, primarily MMP-2 and MMP-9 in DR and also their participation in oxidative stress, mitochondrial dysfunction, and apoptosis, along with their involvement in various signaling pathways. This review also underscores different strategies to inhibit MMPs, thus suggesting that MMPs may represent a putative therapeutic target in the treatment of DR." @default.
- W2890580771 created "2018-09-27" @default.
- W2890580771 creator A5013584043 @default.
- W2890580771 creator A5051760040 @default.
- W2890580771 creator A5060026408 @default.
- W2890580771 creator A5091192388 @default.
- W2890580771 date "2019-02-15" @default.
- W2890580771 modified "2023-10-16" @default.
- W2890580771 title "Targeting Matrix Metalloproteinases for Diabetic Retinopathy: The Way Ahead?" @default.
- W2890580771 cites W1428077152 @default.
- W2890580771 cites W1965498876 @default.
- W2890580771 cites W1966509437 @default.
- W2890580771 cites W1967813793 @default.
- W2890580771 cites W1971032204 @default.
- W2890580771 cites W1973256343 @default.
- W2890580771 cites W1975241491 @default.
- W2890580771 cites W1978302160 @default.
- W2890580771 cites W1979582327 @default.
- W2890580771 cites W1984257538 @default.
- W2890580771 cites W1985705655 @default.
- W2890580771 cites W1998986941 @default.
- W2890580771 cites W2006298215 @default.
- W2890580771 cites W2007859267 @default.
- W2890580771 cites W2018858030 @default.
- W2890580771 cites W2019426766 @default.
- W2890580771 cites W2021943866 @default.
- W2890580771 cites W2022597796 @default.
- W2890580771 cites W2023134524 @default.
- W2890580771 cites W2024390255 @default.
- W2890580771 cites W2027111051 @default.
- W2890580771 cites W2037435316 @default.
- W2890580771 cites W2039097937 @default.
- W2890580771 cites W2040310510 @default.
- W2890580771 cites W2042621583 @default.
- W2890580771 cites W2043392643 @default.
- W2890580771 cites W2044037627 @default.
- W2890580771 cites W2047640394 @default.
- W2890580771 cites W2051209405 @default.
- W2890580771 cites W2053687002 @default.
- W2890580771 cites W205885735 @default.
- W2890580771 cites W2061250188 @default.
- W2890580771 cites W2061599085 @default.
- W2890580771 cites W2062930884 @default.
- W2890580771 cites W2063507014 @default.
- W2890580771 cites W2065249866 @default.
- W2890580771 cites W2069488850 @default.
- W2890580771 cites W2076424412 @default.
- W2890580771 cites W2083207610 @default.
- W2890580771 cites W2084048949 @default.
- W2890580771 cites W2084323667 @default.
- W2890580771 cites W2090364427 @default.
- W2890580771 cites W2093452971 @default.
- W2890580771 cites W2093620952 @default.
- W2890580771 cites W2095890797 @default.
- W2890580771 cites W2109844644 @default.
- W2890580771 cites W2115857548 @default.
- W2890580771 cites W2134408498 @default.
- W2890580771 cites W2138480916 @default.
- W2890580771 cites W2143067028 @default.
- W2890580771 cites W2144696754 @default.
- W2890580771 cites W2145906274 @default.
- W2890580771 cites W2155879201 @default.
- W2890580771 cites W2164793807 @default.
- W2890580771 cites W2166046873 @default.
- W2890580771 cites W2172049439 @default.
- W2890580771 cites W2205469249 @default.
- W2890580771 cites W2261001830 @default.
- W2890580771 cites W2313881314 @default.
- W2890580771 cites W2320952548 @default.
- W2890580771 cites W2326404665 @default.
- W2890580771 cites W2412929659 @default.
- W2890580771 cites W2413070886 @default.
- W2890580771 cites W2461967278 @default.
- W2890580771 cites W2466609853 @default.
- W2890580771 cites W2498331761 @default.
- W2890580771 cites W2502762003 @default.
- W2890580771 cites W2504637985 @default.
- W2890580771 cites W2530011799 @default.
- W2890580771 cites W2552811811 @default.
- W2890580771 cites W2553391178 @default.
- W2890580771 cites W2560351356 @default.
- W2890580771 cites W2560561599 @default.
- W2890580771 cites W2566447341 @default.
- W2890580771 cites W2569092451 @default.
- W2890580771 cites W2575764448 @default.
- W2890580771 cites W2581765679 @default.
- W2890580771 cites W2590312224 @default.
- W2890580771 cites W2604970475 @default.
- W2890580771 cites W2609699760 @default.
- W2890580771 cites W2621958502 @default.
- W2890580771 cites W2710409284 @default.
- W2890580771 cites W2749697407 @default.
- W2890580771 cites W2771779479 @default.
- W2890580771 cites W2773079918 @default.
- W2890580771 cites W2783721796 @default.
- W2890580771 cites W2791517164 @default.
- W2890580771 doi "https://doi.org/10.2174/1389203719666180914093109" @default.
- W2890580771 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30215334" @default.