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- W2890588080 abstract "INTRODUCTION : Acute myocardial infarction (AMI) is one of the most common diseasesIn hospitalised patients in industrialised countries. The early (30-day) mortalityRate from AMI is ~30%, with more than half of these deaths occurring beforeThe stricken individual reaches the hospital. Although the mortality rate afterAdmission for AMI declined by ~30% over the past two decades,Approximately 1 of every 25 patients who survives the initial hospitalisationDies in the first year after AMI . Mortality is approximately four fold higher inElderly patients (over age 75) compared with younger patients.AMI is one of the important medical emergencies admitted in theHospitals. It is characterised by the presence of clinical features like suddenOnset of severe chest pain with dysponea, palpitation and profuse sweatingLeading to cardiac arrythmias, cardiogenic shock, cardiac failure and death ifNot treated early.Among the biomarkers for diagnosis and prognosis in AMI, theNeopterin, a pteridine derivative is considered to be one of the new novelBio-markers which is found to be elevated in patients with AMI.Neopterin was first isolated from larvae of bee in 1963. EventuallyNeopterin was identified as the fluorescent component that was elevated inThe urine of mice with Ehrlich ascites tumour . Now it is proved that this isThe exclusive product of monocytes / macrophages that have been stimulatedBy interferon gamma, a cytokine that is produced by activated T-lymphocytesAnd nature killer cells.AIMS & OBJECTIVES : To elucidate the role of Neopterin levels and its short termPrognostic significance in AMI, the following objectives are formulated.1. Estimation of levels of Serum Neopterin in AMI.2. Significance of levels of Serum Neopterin during the treatment in the ICCU.3. Correlation of levels of Serum Neopterin with the other cardiac risk Factors.4. The role of Neopterin for the prognostic stratification in AMI. CONCLUSION :In this study it is proved that monocyte / macrophage activation in AMIis reflected by the levels of Neopterin and a strong correlation was foundbetween high levels of Neopterin and MACE.To conclude Neopterin concentrations are usually increased in AMI.Highly elevated Neopterin concentrations are among the best predictors ofadverse outcome in patients with AMI risk.Braunwald had initially proposed risk stratification based on the History,Physical examination and Electrocardiogram.The American college of Cardiology / American Heart Associationguide lines Committee later refined and incorporated cardiac markers for riskstratification.This study postulates that Neopterin can be considered as a new novelBiomarker for the disease activity in AMI and also as a prognostic marker forrisk stratification in AMI to prevent mortality and MACE." @default.
- W2890588080 created "2018-09-27" @default.
- W2890588080 creator A5067862599 @default.
- W2890588080 date "2011-04-01" @default.
- W2890588080 modified "2023-09-27" @default.
- W2890588080 title "A Study on the Level of Serum Neopterin a New Novel Biomarker in Acute Myocardial Infarction." @default.
- W2890588080 hasPublicationYear "2011" @default.
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