FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890591943> ?p ?o ?g. }

• W2890591943 endingPage "282" @default.
• W2890591943 startingPage "268" @default.
• W2890591943 abstract "Traumatic brain injury (TBI) is a significant public health problem around the world. A promising area of research is the characterization of small, drug-like molecules that have potent clinical properties. One pharmacotherapeutic agent in particular, an aminopropyl carbazole called P7C3, was discovered using an in vivo screen to identify new agents that augmented the net magnitude of adult hippocampal neurogenesis. P7C3 greatly enhanced neurogenesis by virtue of increasing survival rates of immature neurons. The potent neuroprotective efficacy of P7C3 is likely due to enhanced nicotinamide phosphoribosyltransferase (NAMPT) activity, which supports critical cellular processes. The scaffold of P7C3 was found to have favorable pharmacokinetic properties, good bioavailability, and was nontoxic. Preclinical studies have shown that administration of the P7C3-series of neuroprotective compounds after TBI can rescue and reverse detrimental cellular events leading to improved functional recovery. In several TBI models and across multiple species, P7C3 and its analogues have produced significant neuroprotection, axonal preservation, robust increases in the net magnitude of adult neurogenesis, protection from injury-induced LTP deficits, and improvement in neurological functioning. This review will elucidate the exciting and diverse therapeutic findings of P7C3 administration in the presence of a complex and multifactorial set of cellular and molecular challenges brought forth by experimental TBI. The clinical potential and broad therapeutic applicability of P7C3 warrants much needed investigation into whether these remedial effects can be replicated in the clinic. P7C3 may serve as an important step forward in the design, understanding, and implementation of pharmacotherapies for treating patients with TBI. This article is part of the Special Issue entitled “Novel Treatments for Traumatic Brain Injury”." @default.
• W2890591943 created "2018-09-27" @default.
• W2890591943 creator A5006287686 @default.
• W2890591943 creator A5011373172 @default.
• W2890591943 creator A5028386576 @default.
• W2890591943 creator A5034765337 @default.
• W2890591943 creator A5040607598 @default.
• W2890591943 creator A5057601283 @default.
• W2890591943 date "2019-02-01" @default.
• W2890591943 modified "2023-10-15" @default.
• W2890591943 title "Neurotherapeutic capacity of P7C3 agents for the treatment of Traumatic Brain Injury" @default.
• W2890591943 cites W1523693806 @default.
• W2890591943 cites W1854313094 @default.
• W2890591943 cites W1889544552 @default.
• W2890591943 cites W1892211249 @default.
• W2890591943 cites W1926145384 @default.
• W2890591943 cites W1959262799 @default.
• W2890591943 cites W1964324925 @default.
• W2890591943 cites W1964483580 @default.
• W2890591943 cites W1969305530 @default.
• W2890591943 cites W1977184712 @default.
• W2890591943 cites W1980387577 @default.
• W2890591943 cites W1980615545 @default.
• W2890591943 cites W1981477005 @default.
• W2890591943 cites W1985211115 @default.
• W2890591943 cites W1989824843 @default.
• W2890591943 cites W1997435185 @default.
• W2890591943 cites W1998846643 @default.
• W2890591943 cites W2002351770 @default.
• W2890591943 cites W2003701712 @default.
• W2890591943 cites W2009782005 @default.
• W2890591943 cites W2013403313 @default.
• W2890591943 cites W2014319455 @default.
• W2890591943 cites W2015093375 @default.
• W2890591943 cites W2023634197 @default.
• W2890591943 cites W2023836268 @default.
• W2890591943 cites W2026206739 @default.
• W2890591943 cites W2026393786 @default.
• W2890591943 cites W2028026764 @default.
• W2890591943 cites W2031131009 @default.
• W2890591943 cites W2044540853 @default.
• W2890591943 cites W2045314069 @default.
• W2890591943 cites W2047301408 @default.
• W2890591943 cites W2059332720 @default.
• W2890591943 cites W2065662771 @default.
• W2890591943 cites W2067168107 @default.
• W2890591943 cites W2067267561 @default.
• W2890591943 cites W2067856703 @default.
• W2890591943 cites W2070632079 @default.
• W2890591943 cites W2071014725 @default.
• W2890591943 cites W2074161856 @default.
• W2890591943 cites W2075043109 @default.
• W2890591943 cites W2079580613 @default.
• W2890591943 cites W2083300478 @default.
• W2890591943 cites W2084652820 @default.
• W2890591943 cites W2087412997 @default.
• W2890591943 cites W2088237929 @default.
• W2890591943 cites W2089204174 @default.
• W2890591943 cites W2089578225 @default.
• W2890591943 cites W2091997230 @default.
• W2890591943 cites W2093301541 @default.
• W2890591943 cites W2102535456 @default.
• W2890591943 cites W2103644619 @default.
• W2890591943 cites W2104000336 @default.
• W2890591943 cites W2110815409 @default.
• W2890591943 cites W2111004700 @default.
• W2890591943 cites W2111993114 @default.
• W2890591943 cites W2113999599 @default.
• W2890591943 cites W2116016048 @default.
• W2890591943 cites W2116609704 @default.
• W2890591943 cites W2118861868 @default.
• W2890591943 cites W2118964113 @default.
• W2890591943 cites W2120343656 @default.
• W2890591943 cites W2120417084 @default.
• W2890591943 cites W2121445258 @default.
• W2890591943 cites W2128332802 @default.
• W2890591943 cites W2129061491 @default.
• W2890591943 cites W2132517957 @default.
• W2890591943 cites W2136863044 @default.
• W2890591943 cites W2141568187 @default.
• W2890591943 cites W2145107163 @default.
• W2890591943 cites W2145235967 @default.
• W2890591943 cites W2149901479 @default.
• W2890591943 cites W2150958921 @default.
• W2890591943 cites W2155395152 @default.
• W2890591943 cites W2158315174 @default.
• W2890591943 cites W2160700740 @default.
• W2890591943 cites W2165368743 @default.
• W2890591943 cites W2168268248 @default.
• W2890591943 cites W2169828275 @default.
• W2890591943 cites W2169945211 @default.
• W2890591943 cites W2169988628 @default.
• W2890591943 cites W2284984697 @default.
• W2890591943 cites W2301016453 @default.
• W2890591943 cites W2305994285 @default.
• W2890591943 cites W2311371522 @default.
• W2890591943 cites W2476740650 @default.
• W2890591943 cites W2488964662 @default.

• next