FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890592347> ?p ?o ?g. }

• W2890592347 endingPage "209" @default.
• W2890592347 startingPage "202" @default.
• W2890592347 abstract "The search for novel therapies for the treatment of Alzheimer’s disease is an urgent need, due to the current paucity of available pharmacological tools and the recent failures obtained in clinical trials. Among other strategies, the modulation of amyloid-triggered neuroinflammation by the endocannabinoid system seems of relevance. Previous data indicate that the enhancement of the endocannabinoid tone through the inhibition of the enzymes responsible for the degradation of their main endogenous ligands may render beneficial effects. Based on previously reported data, in which we described a paradoxical effect of the genetic deletion of the fatty acid amide hydrolase, we here aimed to expand our knowledge on the role of the endocannabinoid system in the context of Alzheimer’s disease. To that end, we inhibited the production of interleukin-1β, one of the main inflammatory cytokines involved in the neuroinflammation triggered by amyloid peptides, in a transgenic mouse model of this disease by using minocycline, a drug known to impair the synthesis of this cytokine. Our data suggest that interleukin-1β may be instrumental in order to achieve the beneficial effects derived of fatty acid amide hydrolase genetic inactivation. This could be appreciated at the molecular (cytokine expression, amyloid production, plaque deposition) as well as behavioral levels (memory impairment). We here describe a previously unknown link between the endocannabinoid system and interleukin-1β in the context of Alzheimer’s disease that open new possibilities for the development of novel therapeutics." @default.
• W2890592347 created "2018-09-27" @default.
• W2890592347 creator A5000357079 @default.
• W2890592347 creator A5002035651 @default.
• W2890592347 creator A5033886535 @default.
• W2890592347 creator A5039965004 @default.
• W2890592347 creator A5050157648 @default.
• W2890592347 creator A5054637908 @default.
• W2890592347 creator A5061605827 @default.
• W2890592347 creator A5063923289 @default.
• W2890592347 creator A5068650882 @default.
• W2890592347 creator A5069206578 @default.
• W2890592347 creator A5070550361 @default.
• W2890592347 creator A5087452947 @default.
• W2890592347 date "2018-11-01" @default.
• W2890592347 modified "2023-10-18" @default.
• W2890592347 title "Role of interleukin 1-beta in the inflammatory response in a fatty acid amide hydrolase-knockout mouse model of Alzheimer’s disease" @default.
• W2890592347 cites W1517915610 @default.
• W2890592347 cites W1564854503 @default.
• W2890592347 cites W1821373092 @default.
• W2890592347 cites W1844147108 @default.
• W2890592347 cites W1910693423 @default.
• W2890592347 cites W1979712793 @default.
• W2890592347 cites W1994580609 @default.
• W2890592347 cites W1999516517 @default.
• W2890592347 cites W2015186493 @default.
• W2890592347 cites W2030938592 @default.
• W2890592347 cites W2043033522 @default.
• W2890592347 cites W2052020187 @default.
• W2890592347 cites W2057270928 @default.
• W2890592347 cites W2058805663 @default.
• W2890592347 cites W2064613938 @default.
• W2890592347 cites W2067262752 @default.
• W2890592347 cites W2074402175 @default.
• W2890592347 cites W2086129284 @default.
• W2890592347 cites W2096401612 @default.
• W2890592347 cites W2105385589 @default.
• W2890592347 cites W2109294439 @default.
• W2890592347 cites W2125405084 @default.
• W2890592347 cites W2130848339 @default.
• W2890592347 cites W2133961780 @default.
• W2890592347 cites W2144657811 @default.
• W2890592347 cites W2145866317 @default.
• W2890592347 cites W2163269381 @default.
• W2890592347 cites W2165092386 @default.
• W2890592347 cites W2170644095 @default.
• W2890592347 cites W2507518402 @default.
• W2890592347 cites W2522554250 @default.
• W2890592347 cites W2619899589 @default.
• W2890592347 cites W2783748971 @default.
• W2890592347 cites W2804427175 @default.
• W2890592347 cites W285121184 @default.
• W2890592347 cites W4247759744 @default.
• W2890592347 doi "https://doi.org/10.1016/j.bcp.2018.09.009" @default.
• W2890592347 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30195729" @default.
• W2890592347 hasPublicationYear "2018" @default.
• W2890592347 type Work @default.
• W2890592347 sameAs 2890592347 @default.
• W2890592347 citedByCount "8" @default.
• W2890592347 countsByYear W28905923472019 @default.
• W2890592347 countsByYear W28905923472021 @default.
• W2890592347 countsByYear W28905923472022 @default.
• W2890592347 countsByYear W28905923472023 @default.
• W2890592347 crossrefType "journal-article" @default.
• W2890592347 hasAuthorship W2890592347A5000357079 @default.
• W2890592347 hasAuthorship W2890592347A5002035651 @default.
• W2890592347 hasAuthorship W2890592347A5033886535 @default.
• W2890592347 hasAuthorship W2890592347A5039965004 @default.
• W2890592347 hasAuthorship W2890592347A5050157648 @default.
• W2890592347 hasAuthorship W2890592347A5054637908 @default.
• W2890592347 hasAuthorship W2890592347A5061605827 @default.
• W2890592347 hasAuthorship W2890592347A5063923289 @default.
• W2890592347 hasAuthorship W2890592347A5068650882 @default.
• W2890592347 hasAuthorship W2890592347A5069206578 @default.
• W2890592347 hasAuthorship W2890592347A5070550361 @default.
• W2890592347 hasAuthorship W2890592347A5087452947 @default.
• W2890592347 hasBestOaLocation W28905923472 @default.
• W2890592347 hasConcept C148001335 @default.
• W2890592347 hasConcept C151730666 @default.
• W2890592347 hasConcept C164027704 @default.
• W2890592347 hasConcept C169760540 @default.
• W2890592347 hasConcept C170493617 @default.
• W2890592347 hasConcept C203014093 @default.
• W2890592347 hasConcept C2776914184 @default.
• W2890592347 hasConcept C2778690821 @default.
• W2890592347 hasConcept C2778938600 @default.
• W2890592347 hasConcept C2779343474 @default.
• W2890592347 hasConcept C2781144285 @default.
• W2890592347 hasConcept C46721173 @default.
• W2890592347 hasConcept C55493867 @default.
• W2890592347 hasConcept C86803240 @default.
• W2890592347 hasConcept C87753298 @default.
• W2890592347 hasConcept C98274493 @default.
• W2890592347 hasConceptScore W2890592347C148001335 @default.
• W2890592347 hasConceptScore W2890592347C151730666 @default.
• W2890592347 hasConceptScore W2890592347C164027704 @default.
• W2890592347 hasConceptScore W2890592347C169760540 @default.
• W2890592347 hasConceptScore W2890592347C170493617 @default.

• next