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- W2890595791 abstract "Detection of Plasmodium antigens provides evidence of malaria infection status and is the basis for most malaria diagnosis. We developed a sensitive bead-based multiplex assay for laboratory use, which simultaneously detects pan-Plasmodium aldolase (pAldo), pan-Plasmodium lactate dehydrogenase (pLDH), and P. falciparum histidine-rich protein 2 (PfHRP2) antigens. The assay was validated against purified recombinant antigens, monospecies malaria infections, and noninfected blood samples. To test against samples collected in an endemic setting, Angolan outpatient samples (n = 1267) were assayed. Of 466 Angolan samples positive for at least 1 antigen, the most common antigen profiles were PfHRP2+/pAldo+/pLDH+ (167, 36%), PfHRP2+/pAldo−/pLDH− (163, 35%), and PfHRP2+/pAldo+/pLDH− (129, 28%). Antigen profile was predictive of polymerase chain reaction (PCR) positivity and parasite density. Eight Angolan samples (1.7%) had no or very low PfHRP2 but were positive for 1 or both of the other antigens. PCR analysis confirmed 3 (0.6%) were P. ovale infections and 2 (0.4%) represented P. falciparum parasites lacking Pfhrp2 and/or Pfhrp3. These are the first reports of Pfhrp2/3 deletion mutants in Angola. High-throughput multiplex antigen detection can inexpensively screen for low-density P. falciparum, non-falciparum, and Pfhrp2/3-deleted parasites to provide population-level antigen estimates and identify specimens requiring further molecular characterization." @default.
- W2890595791 created "2018-09-27" @default.
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- W2890595791 date "2018-09-07" @default.
- W2890595791 modified "2023-10-10" @default.
- W2890595791 title "Screening for<i>Pfhrp2/3</i>-Deleted<i>Plasmodium falciparum</i>, Non-<i>falciparum</i>, and Low-Density Malaria Infections by a Multiplex Antigen Assay" @default.
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- W2890595791 doi "https://doi.org/10.1093/infdis/jiy525" @default.
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