FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890596621> ?p ?o ?g. }

• W2890596621 endingPage "2870" @default.
• W2890596621 startingPage "2862" @default.
• W2890596621 abstract "To investigate tumor clonal evolution in hepatocellular carcinoma (HCC), we collected 31 tumor samples,16 peritumor samples and matched PBMCs from 11 long‐term follow‐up patients with HCC. Whole‐exome sequencing was performed to obtain SNVs and CNVs for each sample. An average of 652.2 somatic mutations were identified in each patient and the mean percentage of nonubiquitous tumor mutations was 63.7% (range, 0.7%–100%), reflecting the variety of tumor heterogeneity. Further analysis of clonal evolution was conducted based on mutation clustering results and revealed that different clonal evolution patterns indeed existed in single and multifocal HCC while these patterns were significantly correlated to patients’ clinical course. These patterns clearly demonstrated different mechanisms of tumor recurrence. During tumor clonal evolution, potential therapeutic targets also emerged and vanished dynamically. Moreover, mutation analysis revealed that the contribution of mutational signature was correlated with clonal evolution history. Target sequencing of follow‐up plasma samples also confirmed that ctDNA level could dynamically reflect tumor clonal/subclonal burden. By investigating clonal evolution in HCC patients, our analysis revealed that different patterns indeed existed during HCC progression and proposed a novel strategy for identifying the origin of recurrent tumor as well as optimizing treatment selection." @default.
• W2890596621 created "2018-09-27" @default.
• W2890596621 creator A5004937453 @default.
• W2890596621 creator A5047737377 @default.
• W2890596621 creator A5058278157 @default.
• W2890596621 creator A5060756283 @default.
• W2890596621 creator A5061568119 @default.
• W2890596621 creator A5079207369 @default.
• W2890596621 creator A5081245050 @default.
• W2890596621 creator A5084211654 @default.
• W2890596621 creator A5084959058 @default.
• W2890596621 creator A5085070734 @default.
• W2890596621 date "2018-10-03" @default.
• W2890596621 modified "2023-09-30" @default.
• W2890596621 title "Clonal evolution in long-term follow-up patients with hepatocellular carcinoma" @default.
• W2890596621 cites W1979115864 @default.
• W2890596621 cites W2018851752 @default.
• W2890596621 cites W2023560061 @default.
• W2890596621 cites W2040458067 @default.
• W2890596621 cites W2046855324 @default.
• W2890596621 cites W2047039797 @default.
• W2890596621 cites W2053557262 @default.
• W2890596621 cites W2060043441 @default.
• W2890596621 cites W2107126369 @default.
• W2890596621 cites W2117197109 @default.
• W2890596621 cites W2151794156 @default.
• W2890596621 cites W2234453634 @default.
• W2890596621 cites W2259572413 @default.
• W2890596621 cites W2272984102 @default.
• W2890596621 cites W2286057510 @default.
• W2890596621 cites W2410468716 @default.
• W2890596621 cites W2530391744 @default.
• W2890596621 cites W2535937073 @default.
• W2890596621 cites W2548504727 @default.
• W2890596621 cites W2560102897 @default.
• W2890596621 cites W2586629973 @default.
• W2890596621 cites W2592816381 @default.
• W2890596621 cites W2595761631 @default.
• W2890596621 cites W2618056026 @default.
• W2890596621 cites W2730336810 @default.
• W2890596621 cites W2760863738 @default.
• W2890596621 cites W2767281692 @default.
• W2890596621 doi "https://doi.org/10.1002/ijc.31844" @default.
• W2890596621 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30183077" @default.
• W2890596621 hasPublicationYear "2018" @default.
• W2890596621 type Work @default.
• W2890596621 sameAs 2890596621 @default.
• W2890596621 citedByCount "16" @default.
• W2890596621 countsByYear W28905966212019 @default.
• W2890596621 countsByYear W28905966212020 @default.
• W2890596621 countsByYear W28905966212021 @default.
• W2890596621 countsByYear W28905966212022 @default.
• W2890596621 countsByYear W28905966212023 @default.
• W2890596621 crossrefType "journal-article" @default.
• W2890596621 hasAuthorship W2890596621A5004937453 @default.
• W2890596621 hasAuthorship W2890596621A5047737377 @default.
• W2890596621 hasAuthorship W2890596621A5058278157 @default.
• W2890596621 hasAuthorship W2890596621A5060756283 @default.
• W2890596621 hasAuthorship W2890596621A5061568119 @default.
• W2890596621 hasAuthorship W2890596621A5079207369 @default.
• W2890596621 hasAuthorship W2890596621A5081245050 @default.
• W2890596621 hasAuthorship W2890596621A5084211654 @default.
• W2890596621 hasAuthorship W2890596621A5084959058 @default.
• W2890596621 hasAuthorship W2890596621A5085070734 @default.
• W2890596621 hasBestOaLocation W28905966211 @default.
• W2890596621 hasConcept C104317684 @default.
• W2890596621 hasConcept C10590036 @default.
• W2890596621 hasConcept C113968399 @default.
• W2890596621 hasConcept C121608353 @default.
• W2890596621 hasConcept C134305767 @default.
• W2890596621 hasConcept C16671776 @default.
• W2890596621 hasConcept C2778019345 @default.
• W2890596621 hasConcept C2779256057 @default.
• W2890596621 hasConcept C3018028425 @default.
• W2890596621 hasConcept C501734568 @default.
• W2890596621 hasConcept C502942594 @default.
• W2890596621 hasConcept C54355233 @default.
• W2890596621 hasConcept C86803240 @default.
• W2890596621 hasConceptScore W2890596621C104317684 @default.
• W2890596621 hasConceptScore W2890596621C10590036 @default.
• W2890596621 hasConceptScore W2890596621C113968399 @default.
• W2890596621 hasConceptScore W2890596621C121608353 @default.
• W2890596621 hasConceptScore W2890596621C134305767 @default.
• W2890596621 hasConceptScore W2890596621C16671776 @default.
• W2890596621 hasConceptScore W2890596621C2778019345 @default.
• W2890596621 hasConceptScore W2890596621C2779256057 @default.
• W2890596621 hasConceptScore W2890596621C3018028425 @default.
• W2890596621 hasConceptScore W2890596621C501734568 @default.
• W2890596621 hasConceptScore W2890596621C502942594 @default.
• W2890596621 hasConceptScore W2890596621C54355233 @default.
• W2890596621 hasConceptScore W2890596621C86803240 @default.
• W2890596621 hasIssue "11" @default.
• W2890596621 hasLocation W28905966211 @default.
• W2890596621 hasOpenAccess W2890596621 @default.
• W2890596621 hasPrimaryLocation W28905966211 @default.
• W2890596621 hasRelatedWork W1480540175 @default.
• W2890596621 hasRelatedWork W2159173718 @default.
• W2890596621 hasRelatedWork W2285326560 @default.

• next