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• W2890611249 endingPage "11697" @default.
• W2890611249 startingPage "11686" @default.
• W2890611249 abstract "Photoacoustic (PA) tomography is a noninvasive technology that utilizes near-infrared (NIR) excitation and ultrasonic detection to image biological tissue at centimeter depths. While several activatable small-molecule PA sensors have been developed for various analytes, the use of PA molecules for deep-tissue analyte delivery and monitoring remains an underexplored area of research. Herein, we describe the synthesis, characterization, and in vivo validation of photoNOD-1 and photoNOD-2, the first organic, NIR-photocontrolled nitric oxide (NO) donors that incorporate a PA readout of analyte release. These molecules consist of an aza-BODIPY dye appended with an aryl N-nitrosamine NO-donating moiety. The photoNODs exhibit chemostability to various biological stimuli, including redox-active metals and CYP450 enzymes, and demonstrate negligible cytotoxicity in the absence of irradiation. Upon single-photon NIR irradiation, photoNOD-1 and photoNOD-2 release NO as well as rNOD-1 or rNOD-2, PA-active products that enable ratiometric monitoring of NO release. Our in vitro studies show that, upon irradiation, photoNOD-1 and photoNOD-2 exhibit 46.6-fold and 21.5-fold ratiometric turn-ons, respectively. Moreover, unlike existing NIR NO donors, the photoNODs do not require encapsulation or multiphoton activation for use in live animals. In this study, we use PA tomography to monitor the local, irradiation-dependent release of NO from photoNOD-1 and photoNOD-2 in mice after subcutaneous treatment. In addition, we use a murine model for breast cancer to show that photoNOD-1 can selectively affect tumor growth rates in the presence of NIR light stimulation following systemic administration." @default.
• W2890611249 created "2018-09-27" @default.
• W2890611249 creator A5004275756 @default.
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• W2890611249 creator A5073201453 @default.
• W2890611249 creator A5090527087 @default.
• W2890611249 date "2018-09-10" @default.
• W2890611249 modified "2023-10-13" @default.
• W2890611249 title "Near-Infrared Photoactivatable Nitric Oxide Donors with Integrated Photoacoustic Monitoring" @default.
• W2890611249 cites W1147349766 @default.
• W2890611249 cites W126598016 @default.
• W2890611249 cites W1491953973 @default.
• W2890611249 cites W1502453110 @default.
• W2890611249 cites W1507916795 @default.
• W2890611249 cites W1545012941 @default.
• W2890611249 cites W1560571961 @default.
• W2890611249 cites W1565085298 @default.
• W2890611249 cites W1807868185 @default.
• W2890611249 cites W1836480682 @default.
• W2890611249 cites W1913099668 @default.
• W2890611249 cites W1965931590 @default.
• W2890611249 cites W1969343250 @default.
• W2890611249 cites W1971377175 @default.
• W2890611249 cites W1972858609 @default.
• W2890611249 cites W1985028563 @default.
• W2890611249 cites W1991597890 @default.
• W2890611249 cites W1994207920 @default.
• W2890611249 cites W2001829142 @default.
• W2890611249 cites W2009716635 @default.
• W2890611249 cites W2009843519 @default.
• W2890611249 cites W2012253286 @default.
• W2890611249 cites W2012907132 @default.
• W2890611249 cites W2013715338 @default.
• W2890611249 cites W2017533109 @default.
• W2890611249 cites W2017944880 @default.
• W2890611249 cites W2019384033 @default.
• W2890611249 cites W2023275162 @default.
• W2890611249 cites W2023812730 @default.
• W2890611249 cites W2026038242 @default.
• W2890611249 cites W2030046055 @default.
• W2890611249 cites W2038720700 @default.
• W2890611249 cites W2041060053 @default.
• W2890611249 cites W2051487850 @default.
• W2890611249 cites W2052863704 @default.
• W2890611249 cites W2059978499 @default.
• W2890611249 cites W2061611744 @default.
• W2890611249 cites W2066874348 @default.
• W2890611249 cites W2069432717 @default.
• W2890611249 cites W2070159291 @default.
• W2890611249 cites W2071293996 @default.
• W2890611249 cites W2072379045 @default.
• W2890611249 cites W2074958911 @default.
• W2890611249 cites W2075244890 @default.
• W2890611249 cites W2078324381 @default.
• W2890611249 cites W2078974772 @default.
• W2890611249 cites W2080559907 @default.
• W2890611249 cites W2082888074 @default.
• W2890611249 cites W2083122354 @default.
• W2890611249 cites W2087525987 @default.
• W2890611249 cites W2093218184 @default.
• W2890611249 cites W2101301256 @default.
• W2890611249 cites W2104799708 @default.
• W2890611249 cites W2106941590 @default.
• W2890611249 cites W2119416582 @default.
• W2890611249 cites W2120302444 @default.
• W2890611249 cites W2128569116 @default.
• W2890611249 cites W2132527874 @default.
• W2890611249 cites W2134404850 @default.
• W2890611249 cites W2155127143 @default.
• W2890611249 cites W2156682648 @default.
• W2890611249 cites W2157201795 @default.
• W2890611249 cites W2160267495 @default.
• W2890611249 cites W2166316639 @default.
• W2890611249 cites W2169560941 @default.
• W2890611249 cites W2188059502 @default.
• W2890611249 cites W2258701952 @default.
• W2890611249 cites W2260055826 @default.
• W2890611249 cites W2264664749 @default.
• W2890611249 cites W2277388251 @default.
• W2890611249 cites W2318063141 @default.
• W2890611249 cites W2323069486 @default.
• W2890611249 cites W2330470950 @default.
• W2890611249 cites W2337585522 @default.
• W2890611249 cites W2345395142 @default.
• W2890611249 cites W2435246057 @default.
• W2890611249 cites W2484448248 @default.
• W2890611249 cites W2500522403 @default.
• W2890611249 cites W2512430192 @default.
• W2890611249 cites W2518267890 @default.
• W2890611249 cites W2533023495 @default.
• W2890611249 cites W2552497161 @default.
• W2890611249 cites W2588921633 @default.
• W2890611249 cites W2619265316 @default.
• W2890611249 cites W2648810102 @default.
• W2890611249 cites W2725932575 @default.
• W2890611249 cites W2759626673 @default.

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