Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890613174> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2890613174 abstract "e15541 Background: The role of aldehyde dehydrogenase 2 (ALDH 2) in alcohol metabolism has been ascertained, yet the association between ALDH2 genotype and the carcinogenesis of gastric cancer remains controversy. Methods: We retrospectively collected data of 292 subjects hospitalized in Zhongshan Hospital in Shanghai during March 2016 to September 2016. All subjects were divided into case group (identified with gastric cancer by postoperative pathology) and control group. Distribution of aldehyde dehydrogenase 2 genotype, drinking status along with other clinical variables were compared. Logistic regression model included age, gender, smoking and drinking status, family history and ALDH2 genotype. Adjusted odds ratios (ORs) were calculated. Results: There was a significant elevation of alchohol consumption in case group (P = 0.033). Subjects with ALDH2 *1/*2 and *2/*2 genotype showed less inclination for drinking than ALDH2 *1/*1 (P < 0.001). The risk for gastric cancer showed no differences among subjects with ALDH2 genotype adjusted drinking status [OR 1.121, 95% confidence interval (CI) 0.555-2.263 in Never/rare drinkers; OR 3.380, 95% CI 0.232-49.240 in Light drinkers and OR 2.416, 95% CI 0.326-14.151). Further analysis indicated that high body weight index (BMI) and heavy smoking were individual risk factors for gastric cancer among Light/heavy dringkers with ALDH2 *1/*2 or *2/*2 genotype (OR 84.736, P = 0.021 for BMI and OR 3.904, P = 0.037 for smoking). Conclusions: A dose-response relationship between alchohol consumption and risk for gastric cancer was observed in primary analysis. However ALDH2 genotype failed to modify the alchohol consumption. Our findings suggested that there might be other pathways to further explain the mechanisim of the role of alchohol consumption in carcinogenisis of gastric cancer." @default.
- W2890613174 created "2018-09-27" @default.
- W2890613174 creator A5008321836 @default.
- W2890613174 creator A5016393389 @default.
- W2890613174 creator A5031674072 @default.
- W2890613174 creator A5040074001 @default.
- W2890613174 creator A5047000286 @default.
- W2890613174 creator A5062986540 @default.
- W2890613174 creator A5065911466 @default.
- W2890613174 creator A5070547367 @default.
- W2890613174 date "2017-05-20" @default.
- W2890613174 modified "2023-09-26" @default.
- W2890613174 title "Alcohol consumption adjusted by aldehyde dehydrogenase 2 genotype: A potential risk factor for gastric cancer?" @default.
- W2890613174 doi "https://doi.org/10.1200/jco.2017.35.15_suppl.e15541" @default.
- W2890613174 hasPublicationYear "2017" @default.
- W2890613174 type Work @default.
- W2890613174 sameAs 2890613174 @default.
- W2890613174 citedByCount "0" @default.
- W2890613174 crossrefType "journal-article" @default.
- W2890613174 hasAuthorship W2890613174A5008321836 @default.
- W2890613174 hasAuthorship W2890613174A5016393389 @default.
- W2890613174 hasAuthorship W2890613174A5031674072 @default.
- W2890613174 hasAuthorship W2890613174A5040074001 @default.
- W2890613174 hasAuthorship W2890613174A5047000286 @default.
- W2890613174 hasAuthorship W2890613174A5062986540 @default.
- W2890613174 hasAuthorship W2890613174A5065911466 @default.
- W2890613174 hasAuthorship W2890613174A5070547367 @default.
- W2890613174 hasConcept C104317684 @default.
- W2890613174 hasConcept C121608353 @default.
- W2890613174 hasConcept C126322002 @default.
- W2890613174 hasConcept C135763542 @default.
- W2890613174 hasConcept C143998085 @default.
- W2890613174 hasConcept C25747580 @default.
- W2890613174 hasConcept C2777344606 @default.
- W2890613174 hasConcept C2781066024 @default.
- W2890613174 hasConcept C3019635848 @default.
- W2890613174 hasConcept C3175096 @default.
- W2890613174 hasConcept C50440223 @default.
- W2890613174 hasConcept C54355233 @default.
- W2890613174 hasConcept C55493867 @default.
- W2890613174 hasConcept C71924100 @default.
- W2890613174 hasConcept C86803240 @default.
- W2890613174 hasConcept C99454951 @default.
- W2890613174 hasConceptScore W2890613174C104317684 @default.
- W2890613174 hasConceptScore W2890613174C121608353 @default.
- W2890613174 hasConceptScore W2890613174C126322002 @default.
- W2890613174 hasConceptScore W2890613174C135763542 @default.
- W2890613174 hasConceptScore W2890613174C143998085 @default.
- W2890613174 hasConceptScore W2890613174C25747580 @default.
- W2890613174 hasConceptScore W2890613174C2777344606 @default.
- W2890613174 hasConceptScore W2890613174C2781066024 @default.
- W2890613174 hasConceptScore W2890613174C3019635848 @default.
- W2890613174 hasConceptScore W2890613174C3175096 @default.
- W2890613174 hasConceptScore W2890613174C50440223 @default.
- W2890613174 hasConceptScore W2890613174C54355233 @default.
- W2890613174 hasConceptScore W2890613174C55493867 @default.
- W2890613174 hasConceptScore W2890613174C71924100 @default.
- W2890613174 hasConceptScore W2890613174C86803240 @default.
- W2890613174 hasConceptScore W2890613174C99454951 @default.
- W2890613174 hasLocation W28906131741 @default.
- W2890613174 hasOpenAccess W2890613174 @default.
- W2890613174 hasPrimaryLocation W28906131741 @default.
- W2890613174 hasRelatedWork W1511671061 @default.
- W2890613174 hasRelatedWork W1833562460 @default.
- W2890613174 hasRelatedWork W1987086947 @default.
- W2890613174 hasRelatedWork W1990159335 @default.
- W2890613174 hasRelatedWork W2002733346 @default.
- W2890613174 hasRelatedWork W2007869964 @default.
- W2890613174 hasRelatedWork W2033485319 @default.
- W2890613174 hasRelatedWork W2073226547 @default.
- W2890613174 hasRelatedWork W2107063554 @default.
- W2890613174 hasRelatedWork W2139874167 @default.
- W2890613174 hasRelatedWork W2149389947 @default.
- W2890613174 hasRelatedWork W2150092781 @default.
- W2890613174 hasRelatedWork W2165373217 @default.
- W2890613174 hasRelatedWork W2169422423 @default.
- W2890613174 hasRelatedWork W2259817745 @default.
- W2890613174 hasRelatedWork W2319395651 @default.
- W2890613174 hasRelatedWork W2347876451 @default.
- W2890613174 hasRelatedWork W2796036289 @default.
- W2890613174 hasRelatedWork W3013364759 @default.
- W2890613174 hasRelatedWork W3015559997 @default.
- W2890613174 isParatext "false" @default.
- W2890613174 isRetracted "false" @default.
- W2890613174 magId "2890613174" @default.
- W2890613174 workType "article" @default.