FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890613224> ?p ?o ?g. }

• W2890613224 endingPage "102" @default.
• W2890613224 startingPage "96" @default.
• W2890613224 abstract "Noroviruses are a leading cause of acute gastroenteritis in all age groups. They generally cause a rapidly self-limiting illness. However, chronic norovirus diarrheal disease occurs in immunocompromised individuals, and is accompanied by persistent shedding of infectious norovirus in stool.The study aims to characterize a novel GII.P26-GII.26 norovirus strain. Furthermore, it analyses viral mutations arising during chronic infection of an immunocompromised host.Over the course of more than three years, stool samples were obtained from an immunocompromised patient and screened for the presence of norovirus RNA by real-time PCR and norovirus antigen by immunoassay. Viral population kinetics was analyzed by conventional and high-throughput-sequencing.Real-time PCR yielded high amounts of norovirus RNA in the stool, but antigen immunoassays failed to detect the virus. The near complete norovirus genome was assigned as novel GII.P26-GII.26 genotype. Conventional as well as high-throughput sequencing pointed to a heterogeneous viral population with low rates of non-synonymous substitutions. Within-host evolution was enhanced in non-structural protein p22 and the N-terminal arm of the capsid protein VP1 but reduced in the viral polymerase RdRp. Intermittent non-synonymous substitutions in the protruding domain of the VP1 reverted fully over time.Confirmation of novel GII.P26-GII.26 norovirus genotypes provides insight into norovirus genetic diversity. The study further illustrates norovirus infection as an important differential diagnosis of recurrent persistent diarrhea in immunocompromised patients. The provided data on within-host evolution contribute to the insight of the mechanisms of viral persistence and pathogenesis in chronic norovirus infections." @default.
• W2890613224 created "2018-09-27" @default.
• W2890613224 creator A5025247414 @default.
• W2890613224 creator A5064870455 @default.
• W2890613224 creator A5076693038 @default.
• W2890613224 creator A5088343134 @default.
• W2890613224 date "2018-11-01" @default.
• W2890613224 modified "2023-10-14" @default.
• W2890613224 title "Within-host evolution of virus variants during chronic infection with novel GII.P26-GII.26 norovirus" @default.
• W2890613224 cites W1521991220 @default.
• W2890613224 cites W1977675767 @default.
• W2890613224 cites W1983511569 @default.
• W2890613224 cites W1985684734 @default.
• W2890613224 cites W1995126952 @default.
• W2890613224 cites W2008881117 @default.
• W2890613224 cites W2010860285 @default.
• W2890613224 cites W2014075152 @default.
• W2890613224 cites W2022983554 @default.
• W2890613224 cites W2028409515 @default.
• W2890613224 cites W2056076091 @default.
• W2890613224 cites W2066128679 @default.
• W2890613224 cites W2079799398 @default.
• W2890613224 cites W2096618918 @default.
• W2890613224 cites W2099952022 @default.
• W2890613224 cites W2115151801 @default.
• W2890613224 cites W2132347143 @default.
• W2890613224 cites W2132360846 @default.
• W2890613224 cites W2132632499 @default.
• W2890613224 cites W2138357876 @default.
• W2890613224 cites W2141089027 @default.
• W2890613224 cites W2145102665 @default.
• W2890613224 cites W2195900913 @default.
• W2890613224 cites W2311143658 @default.
• W2890613224 cites W2316537820 @default.
• W2890613224 cites W2334072862 @default.
• W2890613224 cites W2343412274 @default.
• W2890613224 cites W2463702166 @default.
• W2890613224 cites W2563669729 @default.
• W2890613224 cites W2587692003 @default.
• W2890613224 cites W2754076641 @default.
• W2890613224 cites W2760731030 @default.
• W2890613224 cites W2771275312 @default.
• W2890613224 cites W2787814030 @default.
• W2890613224 cites W2792876461 @default.
• W2890613224 doi "https://doi.org/10.1016/j.jcv.2018.09.013" @default.
• W2890613224 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30268000" @default.
• W2890613224 hasPublicationYear "2018" @default.
• W2890613224 type Work @default.
• W2890613224 sameAs 2890613224 @default.
• W2890613224 citedByCount "11" @default.
• W2890613224 countsByYear W28906132242019 @default.
• W2890613224 countsByYear W28906132242020 @default.
• W2890613224 countsByYear W28906132242021 @default.
• W2890613224 countsByYear W28906132242022 @default.
• W2890613224 countsByYear W28906132242023 @default.
• W2890613224 crossrefType "journal-article" @default.
• W2890613224 hasAuthorship W2890613224A5025247414 @default.
• W2890613224 hasAuthorship W2890613224A5064870455 @default.
• W2890613224 hasAuthorship W2890613224A5076693038 @default.
• W2890613224 hasAuthorship W2890613224A5088343134 @default.
• W2890613224 hasConcept C104317684 @default.
• W2890613224 hasConcept C135763542 @default.
• W2890613224 hasConcept C159047783 @default.
• W2890613224 hasConcept C202878990 @default.
• W2890613224 hasConcept C2522874641 @default.
• W2890613224 hasConcept C2778750513 @default.
• W2890613224 hasConcept C2908647359 @default.
• W2890613224 hasConcept C54355233 @default.
• W2890613224 hasConcept C71924100 @default.
• W2890613224 hasConcept C86803240 @default.
• W2890613224 hasConcept C99454951 @default.
• W2890613224 hasConceptScore W2890613224C104317684 @default.
• W2890613224 hasConceptScore W2890613224C135763542 @default.
• W2890613224 hasConceptScore W2890613224C159047783 @default.
• W2890613224 hasConceptScore W2890613224C202878990 @default.
• W2890613224 hasConceptScore W2890613224C2522874641 @default.
• W2890613224 hasConceptScore W2890613224C2778750513 @default.
• W2890613224 hasConceptScore W2890613224C2908647359 @default.
• W2890613224 hasConceptScore W2890613224C54355233 @default.
• W2890613224 hasConceptScore W2890613224C71924100 @default.
• W2890613224 hasConceptScore W2890613224C86803240 @default.
• W2890613224 hasConceptScore W2890613224C99454951 @default.
• W2890613224 hasLocation W28906132241 @default.
• W2890613224 hasLocation W28906132242 @default.
• W2890613224 hasOpenAccess W2890613224 @default.
• W2890613224 hasPrimaryLocation W28906132241 @default.
• W2890613224 hasRelatedWork W1528827813 @default.
• W2890613224 hasRelatedWork W1951857842 @default.
• W2890613224 hasRelatedWork W1969386671 @default.
• W2890613224 hasRelatedWork W2086041405 @default.
• W2890613224 hasRelatedWork W2127511777 @default.
• W2890613224 hasRelatedWork W3029408938 @default.
• W2890613224 hasRelatedWork W4200345808 @default.
• W2890613224 hasRelatedWork W4285088608 @default.
• W2890613224 hasRelatedWork W4292583681 @default.
• W2890613224 hasRelatedWork W4307774250 @default.
• W2890613224 hasVolume "108" @default.
• W2890613224 isParatext "false" @default.

• next