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- W2890614541 abstract "The current study is emphasized on development of a nanoemulsion system that simultaneously delivers two antipsoriatic agents viz. Tacrolimus and Kalonji oil (functional excepient) topically.A nanoemulsion was characterized for quality attributes; a nanoemulsion gel was evaluated for spreadability, viscosity, dermal bioavailability, and in vitro efficacy in A-431 cell line, and so forth. In vivo performance was evaluated on psoriasis model in BALB/c mice.Nanoemulsion depicted droplet size: 93.37 ± 2.58 nm with PDI (Polydispersity Index) 0.330 ± 0.025. The nanoemulsion gel exhibited desirable spreadability with sustained release pattern (biphasic). Dermal bioavailability enhancement (4.33-fold) accompanied significant in vitro results. A significant reduction in serum cytokines and improvement in psoriatic condition was achieved in vivo, indicating formulation efficacy compared with marketed formulation (Tacroz Forte, Glenmark Pharmaceuticals Ltd, Maharashtra, India).Nanoemulsion gel thus provides an effective alternative for psoriasis treatment." @default.
- W2890614541 created "2018-09-27" @default.
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- W2890614541 date "2018-08-01" @default.
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- W2890614541 title "Active natural oil-based nanoemulsion containing tacrolimus for synergistic antipsoriatic efficacy" @default.
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- W2890614541 doi "https://doi.org/10.2217/nnm-2018-0135" @default.
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