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• W2890617507 abstract "ABSTRACT Bacteria are known to use RNA, either as mRNAs encoding proteins or as noncoding small RNAs (sRNAs), to regulate numerous biological processes. However, a few sRNAs have two functions: they act as base-pairing RNAs and encode a small protein with additional regulatory functions. Thus, these so called “dual-function” sRNAs can serve as both a riboregulator and an mRNA. In some cases, these two functions can act independently within the same pathway, while in other cases, the base-pairing function and protein function act in different pathways. Here, we discuss the five known dual-function sRNAs—SgrS from enteric species, RNAIII and Psm-mec from Staphylococcus aureus , Pel RNA from Streptococcus pyogenes , and SR1 from Bacillus subtilis —and review their mechanisms of action and roles in regulating diverse biological processes. We also discuss the prospect of finding additional dual-function sRNAs and future challenges in studying the overlap and competition between the functions." @default.
• W2890617507 created "2018-09-27" @default.
• W2890617507 creator A5003617560 @default.
• W2890617507 creator A5006548294 @default.
• W2890617507 creator A5030807070 @default.
• W2890617507 creator A5038668170 @default.
• W2890617507 date "2018-09-07" @default.
• W2890617507 modified "2023-10-03" @default.
• W2890617507 title "Dual-Function RNAs" @default.
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