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• W2890618895 abstract "Bradykinin has important physiological actions related to the regulation of blood vessel tone and renal function, and protection from ischemia reperfusion injury. However, bradykinin also contributes to pathological states such as angioedema and inflammation. Bradykinin is metabolized by many different peptidases that play a major role in the control of bradykinin levels. Peptidase inhibitor therapies such as angiotensin converting enzyme (ACE) and neprilysin inhibitors increase bradykinin levels, and the challenge for such therapies is to achieve the beneficial renal and cardiovascular effects without the adverse consequences such as angioedema that may result from increased bradykinin levels. Neprilysin also metabolizes natriuretic peptides. However, despite the potential therapeutic benefit of increased natriuretic peptide and bradykinin levels, neprilysin inhibitor therapy has only modest efficacy in essential hypertension and heart failure. Initial attempts to combine neprilysin inhibition with inhibition of the renin angiotensin system led to the development of omapatrilat, a drug that combines ACE and neprilysin inhibition. However, omapatrilat produced an unacceptably high incidence of angioedema in patients with hypertension (2.17%) in comparison with the ACE inhibitor enalapril (0.68%), although angioedema incidence was less in patients with heart failure with reduced ejection fraction (HFrEF) treated with omapatrilat (0.8%), and not different from that for enalapril therapy (0.5%). More recently, LCZ696, a drug that combines angiotensin receptor and neprilysin inhibition, was approved for the treatment of HFrEF. The approval of LCZ696 therapy for HFrEF represents the first approval of long-term neprilysin inhibitor administration. While angioedema incidence was acceptably low in HFrEF patients receiving LCZ696 therapy (0.45%), it remains to be seen whether LCZ696 therapy for other conditions such as hypertension is also accompanied by an acceptable incidence of angioedema." @default.
• W2890618895 created "2018-09-27" @default.
• W2890618895 creator A5022682140 @default.
• W2890618895 date "2018-09-19" @default.
• W2890618895 modified "2023-10-12" @default.
• W2890618895 title "Neprilysin Inhibitors and Bradykinin" @default.
• W2890618895 cites W109784360 @default.
• W2890618895 cites W124143665 @default.
• W2890618895 cites W124634336 @default.
• W2890618895 cites W1481026332 @default.
• W2890618895 cites W1484962109 @default.
• W2890618895 cites W1486819840 @default.
• W2890618895 cites W1519621899 @default.
• W2890618895 cites W1535139368 @default.
• W2890618895 cites W1544396872 @default.
• W2890618895 cites W1560143001 @default.
• W2890618895 cites W1569900298 @default.
• W2890618895 cites W1764686129 @default.
• W2890618895 cites W1777223861 @default.
• W2890618895 cites W1800849354 @default.
• W2890618895 cites W1830082853 @default.
• W2890618895 cites W1896060457 @default.
• W2890618895 cites W1964822131 @default.
• W2890618895 cites W1967467967 @default.
• W2890618895 cites W1971039109 @default.
• W2890618895 cites W1971998433 @default.
• W2890618895 cites W1972212337 @default.
• W2890618895 cites W1972766768 @default.
• W2890618895 cites W1973986737 @default.
• W2890618895 cites W1975952670 @default.
• W2890618895 cites W1977135574 @default.
• W2890618895 cites W1977458672 @default.
• W2890618895 cites W1979105270 @default.
• W2890618895 cites W1982076095 @default.
• W2890618895 cites W1982525745 @default.
• W2890618895 cites W1982782378 @default.
• W2890618895 cites W1983654162 @default.
• W2890618895 cites W1986197570 @default.
• W2890618895 cites W1988500109 @default.
• W2890618895 cites W1992155766 @default.
• W2890618895 cites W1994035387 @default.
• W2890618895 cites W1997335104 @default.
• W2890618895 cites W1999319209 @default.
• W2890618895 cites W2000181720 @default.
• W2890618895 cites W2003331661 @default.
• W2890618895 cites W2004501435 @default.
• W2890618895 cites W2004587229 @default.
• W2890618895 cites W2008315681 @default.
• W2890618895 cites W2008580181 @default.
• W2890618895 cites W2011713635 @default.
• W2890618895 cites W2012252047 @default.
• W2890618895 cites W2012252766 @default.
• W2890618895 cites W2016085424 @default.
• W2890618895 cites W2019034341 @default.
• W2890618895 cites W2021011733 @default.
• W2890618895 cites W2024057404 @default.
• W2890618895 cites W2026921577 @default.
• W2890618895 cites W2032161953 @default.
• W2890618895 cites W2036015204 @default.
• W2890618895 cites W2038612896 @default.
• W2890618895 cites W2039967952 @default.
• W2890618895 cites W2053292076 @default.
• W2890618895 cites W2053982006 @default.
• W2890618895 cites W2054008469 @default.
• W2890618895 cites W2055229981 @default.
• W2890618895 cites W2055253331 @default.
• W2890618895 cites W2055511533 @default.
• W2890618895 cites W2057351643 @default.
• W2890618895 cites W2058755393 @default.
• W2890618895 cites W2061608226 @default.
• W2890618895 cites W2062011501 @default.
• W2890618895 cites W2065634593 @default.
• W2890618895 cites W2065793802 @default.
• W2890618895 cites W2070640973 @default.
• W2890618895 cites W2084130233 @default.
• W2890618895 cites W2084676138 @default.
• W2890618895 cites W2086078395 @default.
• W2890618895 cites W2086204662 @default.
• W2890618895 cites W2086868114 @default.
• W2890618895 cites W2089573090 @default.
• W2890618895 cites W2091567906 @default.
• W2890618895 cites W2092596981 @default.
• W2890618895 cites W2094282177 @default.
• W2890618895 cites W2097698117 @default.
• W2890618895 cites W2101037152 @default.
• W2890618895 cites W2102953371 @default.
• W2890618895 cites W2113698123 @default.
• W2890618895 cites W2115789382 @default.
• W2890618895 cites W2121063376 @default.
• W2890618895 cites W2123281693 @default.
• W2890618895 cites W2127191583 @default.
• W2890618895 cites W2129701635 @default.
• W2890618895 cites W2133217116 @default.
• W2890618895 cites W2134751690 @default.
• W2890618895 cites W2138543166 @default.
• W2890618895 cites W2139153278 @default.
• W2890618895 cites W2147930568 @default.
• W2890618895 cites W2149694398 @default.
• W2890618895 cites W2151498184 @default.
• W2890618895 cites W2155400583 @default.

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