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- W2890620134 abstract "Background: Volatile anaesthetics (VA) promote protection against liver ischemia reperfusion (IR) injury. Hexafluoro-2-propanol (HFIP) is a primary metabolite of VA sevoflurane that has been associated with beneficial immunomodulatory effects in different models of inflammation. The aim of this study was to investigate if HFIP preconditioning decreases liver normothermic IR injury. Methods: Rats anaesthetised with ketamine-xylazine and mechanical ventilation were submitted to 30 min of partial normothermic liver ischemia (Control group; n = 8), or preconditioned with intravenous HFIP 67 mg/kg, 10 min prior to liver ischemia (HFIP group; n = 8). Immediately after reperfusion non-ischemic liver right and caudate lobes were resected, allowing evaluation global IR liver injury. Blood samples were acquired 4 h after reperfusion. Results: HFIP group showed significantly decreased AST (2,336 ± 809 UI/L) and ALT (2,251 ± 768 UI/L) levels compared to Control (4,859 ± 3,053 UI/L and 4,484 ± 2,678UI/L, respectively). Serum ionized calcium (iCa) and potassium (K) levels were significantly increased in HFIP group (5.256 ± 0.7 mg/dL and 6.813 ± 0.645 mEq/L, respectively) compared to Control (4.773 ± 0.256 mg/dL and 6.086 ± 0.422 mEq/L, respectively). Base excess, bicarbonate, lactate, chloride and glucose levels in HFIP group were not significantly different from Control. Conclusion: In experimental normothremic liver IR injury, HFIP protects the liver demonstrated by marked decrease in liver transaminases. The ionic imbalance of serum K and iCa maybe related to increased intracellular release of both electrolytes involved in the main mechanism of preconditioning liver protection effect. Intravenous HFIP can emerge as a new strategy to liver protection mainly in situations where volatile anaesthetics cannot be applied." @default.
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- W2890620134 date "2018-03-01" @default.
- W2890620134 modified "2023-10-18" @default.
- W2890620134 title "Effects of sevoflurane metabolite hexafluoro-2-propanol preconditioning in experimental liver ischemia reperfusion injury" @default.
- W2890620134 doi "https://doi.org/10.1016/j.hpb.2018.02.027" @default.
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