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• W2890621891 abstract "The widespread consumption of a high-fat ?Western diet? in conjunction with decreased physical activity has created an obesity epidemic with severe health ramifications in aged individuals. Body composition and obesity may represent important mediators in the age-related onset of physical disability. Our previous studies indicate that, with high-fat feeding, aged rats experience a heightened hyperphagia and a delayed normalization in caloric intake, resulting in an exaggerated weight gain, relative to similarly treated young rats. Angiotensin converting enzyme (ACE) inhibitors attenuate declining physical function in aged rats via modification of body composition and modulation of metabolic and inflammatory pathways. Therefore, we sought to determine if the ACE inhibitor enalapril mitigates this hyperphagic response. Twenty-four month old male, F344x BN rats were administered placebo or enalapril (40 mg/kg/day; in food pellet) for four weeks. Thereafter, half of the placebo rats continued to receive regular chow. The other half of the placebo group and the entire enalapril group were given a high-fat diet for thirteen days. Compared with the high-fat-fed placebo rats, which reached a peak caloric intake on Day 1, enalapril high-fat-fed rats demonstrated a more gradual hyperphagia, peaking at Day 4. Overall, body weight in the enalapril high-fat-fed remained lower than placebo high-fat-fed, which was mainly attributable to an attenuation of fat mass gain. Thus, in the context of exposure to a high-fat diet, enalapril may impede the development of obesity via direct modification of body weight/composition and an initial reduction in caloric intake. ( en )" @default.
• W2890621891 created "2018-09-27" @default.
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• W2890621891 date "2011-01-01" @default.
• W2890621891 modified "2023-09-28" @default.
• W2890621891 title "Investigation Into the Effects of Enalapril on Food Intake and Body Composition in High-Fat Fed Aged Rodents." @default.
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