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- W2890622602 abstract "The challenges of managing relapsed ovarian cancer increase as more advanced lines of chemotherapy are achieved.A case study is presented to illustrate the complexities of selecting treatment in a patient with platinum-sensitive relapsed ovarian cancer and exposure to two previous lines of platinum-based chemotherapy.In this clinical scenario, options include re-treatment with platinum-based chemotherapy or treatment with a nonplatinum single-agent or a nonplatinum combination. In this case, the nonplatinum combination of trabectedin + pegylated liposomal doxorubicin (PLD) was selected as the patient had limited platinum sensitivity (progression-free interval of 9 months), no BRCA mutation, and taking into account evidence that the regimen is effective and safe in the third line and beyond and may restore platinum sensitivity. After nine cycles of trabectedin + PLD, there was no evidence of disease. The patient was able to resume normal activities during therapy. Progression-free interval (PFI) was 17 months before disease progression. Subsequent platinum rechallenge produced a partial response.Trabectedin + PLD may be an option for patients with platinum-sensitive relapsed ovarian cancer, including those who have received two or more previous lines of platinum." @default.
- W2890622602 created "2018-09-27" @default.
- W2890622602 creator A5034695241 @default.
- W2890622602 date "2018-09-18" @default.
- W2890622602 modified "2023-09-23" @default.
- W2890622602 title "Trabectedin + pegylated liposomal doxorubicin in third-line treatment of platinum-sensitive relapsed ovarian cancer: a case study" @default.
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- W2890622602 doi "https://doi.org/10.1080/14737140.2018.1513793" @default.
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