FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890622609> ?p ?o ?g. }

• W2890622609 abstract "Clinically relevant sirtuin (SIRT) inhibitors may possess antitumor activities. A previous study indicated that 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) exhibited potent anticancer activity by SIRT1 inhibition. Therefore, the aim of the present study was to investigate whether its derivatives (J11-C1 and J19) exhibited anticancer activity against ovarian cancer SKOV3 cells. Cell viability was determined using an MTT assay. Cell cycle arrest, apoptosis and autophagy were determined using flow cytometry or western blot analysis. J11-Cl and J19 were less cytotoxic to SKOV3 cells compared with 15d-PGJ2. Molecular docking studies supported the interactions of 15d-PGJ2, J11-Cl and J19 with various amino acids in SIRT1 proteins. Similar to 15d-PGJ2, J11-C1 and J19 inhibited SIRT1 enzymatic activity and decreased SIRT1 expression levels in a concentration-dependent manner. J11-C1 induced apoptotic cell death more effectively compared with J19, which was associated with markedly decreased expression of the anti-apoptotic molecule B-cell lymphoma 2 (Bcl-2). Furthermore, the levels of light chain 3-Ⅱ (LC3-II) and beclin-1 were clearly induced in SKOV3 cells treated with J11-Cl. Thus, 15d-PGJ2 and its derivatives exhibited anticancer activity possibly by inducing apoptotic or autophagic cell death pathways. Collectively, the results of the present study suggest that 15d-PGJ2 and its derivatives exerted antitumor activity by selectively modulating the expression of genes associated with cell cycle arrest, apoptosis and autophagy. Notably, J11-C1 is a novel candidate SIRT1 inhibitor with anticancer activity." @default.
• W2890622609 created "2018-09-27" @default.
• W2890622609 creator A5008833668 @default.
• W2890622609 creator A5035224329 @default.
• W2890622609 creator A5046908030 @default.
• W2890622609 creator A5052433739 @default.
• W2890622609 creator A5055461491 @default.
• W2890622609 creator A5057756650 @default.
• W2890622609 creator A5061814504 @default.
• W2890622609 creator A5065986300 @default.
• W2890622609 creator A5075093370 @default.
• W2890622609 date "2018-09-13" @default.
• W2890622609 modified "2023-10-03" @default.
• W2890622609 title "Novel SIRT1 inhibitor 15-deoxy-Δ12,14-prostaglandin J2 and its derivatives exhibit anticancer activity through apoptotic or autophagic cell death pathways in SKOV3 cells" @default.
• W2890622609 cites W10640494 @default.
• W2890622609 cites W1812573520 @default.
• W2890622609 cites W1973508024 @default.
• W2890622609 cites W1975507466 @default.
• W2890622609 cites W1981687780 @default.
• W2890622609 cites W1985588649 @default.
• W2890622609 cites W1995257560 @default.
• W2890622609 cites W2009423060 @default.
• W2890622609 cites W2012709981 @default.
• W2890622609 cites W2022040605 @default.
• W2890622609 cites W2047321776 @default.
• W2890622609 cites W2078873995 @default.
• W2890622609 cites W2091437677 @default.
• W2890622609 cites W2102377211 @default.
• W2890622609 cites W2105812111 @default.
• W2890622609 cites W2110118637 @default.
• W2890622609 cites W2125283861 @default.
• W2890622609 cites W2129153475 @default.
• W2890622609 cites W2130548721 @default.
• W2890622609 cites W2141176449 @default.
• W2890622609 cites W2142845200 @default.
• W2890622609 cites W2162477925 @default.
• W2890622609 cites W2170096414 @default.
• W2890622609 cites W2197446758 @default.
• W2890622609 cites W2257878018 @default.
• W2890622609 cites W2442964323 @default.
• W2890622609 cites W2469702515 @default.
• W2890622609 cites W2566076681 @default.
• W2890622609 cites W2620948159 @default.
• W2890622609 cites W2736015152 @default.
• W2890622609 cites W2736676407 @default.
• W2890622609 cites W2748903785 @default.
• W2890622609 doi "https://doi.org/10.3892/ijo.2018.4561" @default.
• W2890622609 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6203160" @default.
• W2890622609 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30221742" @default.
• W2890622609 hasPublicationYear "2018" @default.
• W2890622609 type Work @default.
• W2890622609 sameAs 2890622609 @default.
• W2890622609 citedByCount "18" @default.
• W2890622609 countsByYear W28906226092019 @default.
• W2890622609 countsByYear W28906226092020 @default.
• W2890622609 countsByYear W28906226092021 @default.
• W2890622609 countsByYear W28906226092022 @default.
• W2890622609 countsByYear W28906226092023 @default.
• W2890622609 crossrefType "journal-article" @default.
• W2890622609 hasAuthorship W2890622609A5008833668 @default.
• W2890622609 hasAuthorship W2890622609A5035224329 @default.
• W2890622609 hasAuthorship W2890622609A5046908030 @default.
• W2890622609 hasAuthorship W2890622609A5052433739 @default.
• W2890622609 hasAuthorship W2890622609A5055461491 @default.
• W2890622609 hasAuthorship W2890622609A5057756650 @default.
• W2890622609 hasAuthorship W2890622609A5061814504 @default.
• W2890622609 hasAuthorship W2890622609A5065986300 @default.
• W2890622609 hasAuthorship W2890622609A5075093370 @default.
• W2890622609 hasBestOaLocation W28906226091 @default.
• W2890622609 hasConcept C105696609 @default.
• W2890622609 hasConcept C121608353 @default.
• W2890622609 hasConcept C1491633281 @default.
• W2890622609 hasConcept C153911025 @default.
• W2890622609 hasConcept C190283241 @default.
• W2890622609 hasConcept C203522944 @default.
• W2890622609 hasConcept C2780783641 @default.
• W2890622609 hasConcept C29537977 @default.
• W2890622609 hasConcept C31573885 @default.
• W2890622609 hasConcept C53227056 @default.
• W2890622609 hasConcept C54355233 @default.
• W2890622609 hasConcept C553184892 @default.
• W2890622609 hasConcept C55493867 @default.
• W2890622609 hasConcept C86803240 @default.
• W2890622609 hasConcept C95444343 @default.
• W2890622609 hasConcept C96232424 @default.
• W2890622609 hasConceptScore W2890622609C105696609 @default.
• W2890622609 hasConceptScore W2890622609C121608353 @default.
• W2890622609 hasConceptScore W2890622609C1491633281 @default.
• W2890622609 hasConceptScore W2890622609C153911025 @default.
• W2890622609 hasConceptScore W2890622609C190283241 @default.
• W2890622609 hasConceptScore W2890622609C203522944 @default.
• W2890622609 hasConceptScore W2890622609C2780783641 @default.
• W2890622609 hasConceptScore W2890622609C29537977 @default.
• W2890622609 hasConceptScore W2890622609C31573885 @default.
• W2890622609 hasConceptScore W2890622609C53227056 @default.
• W2890622609 hasConceptScore W2890622609C54355233 @default.
• W2890622609 hasConceptScore W2890622609C553184892 @default.
• W2890622609 hasConceptScore W2890622609C55493867 @default.
• W2890622609 hasConceptScore W2890622609C86803240 @default.
• W2890622609 hasConceptScore W2890622609C95444343 @default.

• next