Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890623880> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2890623880 endingPage "5" @default.
- W2890623880 startingPage "1" @default.
- W2890623880 abstract "The biguanide drug metformin used for treating Type 2 diabetes has anticancer properties and affects many pathways involving glucose metabolism, energy balance, and cell survival. A number of retrospective clinical studies have indicated a reduced risk of cancer and improved cancer outcomes in Type 2 diabetic patients taking metformin. Several of its effects are mediated through the induction of cellular stress and subsequent activation of AMP kinase, but many other mechanisms act independently of AMP kinase activation. Metformin has been shown to inhibit the effects of tumor necrosis factor (TNF)-alpha. TNF-alpha interferes with insulin signaling to produce insulin resistance in the insulin signaling pathway and promotes apoptosis through NF-KB in the apoptosis pathway. In addition, metformin reduces cellular proliferation by decreasing the amount of available insulin or by directly affecting the mammalian target of rapamycin complex involved with regulating protein synthesis. It can prevent tumors from acquiring stem cell-like properties, upregulate apoptotic pathways, and bolster the immune system’s fight against cancer. Gaining a greater understanding of metformin’s various mechanisms of action will continue to elucidate metformin’s role as an effective treatment for cancer." @default.
- W2890623880 created "2018-09-27" @default.
- W2890623880 creator A5030562456 @default.
- W2890623880 creator A5046364556 @default.
- W2890623880 creator A5077592512 @default.
- W2890623880 creator A5077760740 @default.
- W2890623880 date "2018-01-01" @default.
- W2890623880 modified "2023-09-27" @default.
- W2890623880 title "Metformin: Possible Use of a Diabetes Drug in Treatment of Cancer." @default.
- W2890623880 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7773208" @default.
- W2890623880 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33385166" @default.
- W2890623880 hasPublicationYear "2018" @default.
- W2890623880 type Work @default.
- W2890623880 sameAs 2890623880 @default.
- W2890623880 citedByCount "0" @default.
- W2890623880 crossrefType "journal-article" @default.
- W2890623880 hasAuthorship W2890623880A5030562456 @default.
- W2890623880 hasAuthorship W2890623880A5046364556 @default.
- W2890623880 hasAuthorship W2890623880A5077592512 @default.
- W2890623880 hasAuthorship W2890623880A5077760740 @default.
- W2890623880 hasConcept C104317684 @default.
- W2890623880 hasConcept C121608353 @default.
- W2890623880 hasConcept C126322002 @default.
- W2890623880 hasConcept C127561419 @default.
- W2890623880 hasConcept C134018914 @default.
- W2890623880 hasConcept C190283241 @default.
- W2890623880 hasConcept C2777180221 @default.
- W2890623880 hasConcept C2777391703 @default.
- W2890623880 hasConcept C2777688063 @default.
- W2890623880 hasConcept C2779306644 @default.
- W2890623880 hasConcept C2780323712 @default.
- W2890623880 hasConcept C502942594 @default.
- W2890623880 hasConcept C55493867 @default.
- W2890623880 hasConcept C555293320 @default.
- W2890623880 hasConcept C62478195 @default.
- W2890623880 hasConcept C71924100 @default.
- W2890623880 hasConcept C86803240 @default.
- W2890623880 hasConcept C95444343 @default.
- W2890623880 hasConcept C96232424 @default.
- W2890623880 hasConcept C98274493 @default.
- W2890623880 hasConceptScore W2890623880C104317684 @default.
- W2890623880 hasConceptScore W2890623880C121608353 @default.
- W2890623880 hasConceptScore W2890623880C126322002 @default.
- W2890623880 hasConceptScore W2890623880C127561419 @default.
- W2890623880 hasConceptScore W2890623880C134018914 @default.
- W2890623880 hasConceptScore W2890623880C190283241 @default.
- W2890623880 hasConceptScore W2890623880C2777180221 @default.
- W2890623880 hasConceptScore W2890623880C2777391703 @default.
- W2890623880 hasConceptScore W2890623880C2777688063 @default.
- W2890623880 hasConceptScore W2890623880C2779306644 @default.
- W2890623880 hasConceptScore W2890623880C2780323712 @default.
- W2890623880 hasConceptScore W2890623880C502942594 @default.
- W2890623880 hasConceptScore W2890623880C55493867 @default.
- W2890623880 hasConceptScore W2890623880C555293320 @default.
- W2890623880 hasConceptScore W2890623880C62478195 @default.
- W2890623880 hasConceptScore W2890623880C71924100 @default.
- W2890623880 hasConceptScore W2890623880C86803240 @default.
- W2890623880 hasConceptScore W2890623880C95444343 @default.
- W2890623880 hasConceptScore W2890623880C96232424 @default.
- W2890623880 hasConceptScore W2890623880C98274493 @default.
- W2890623880 hasIssue "1" @default.
- W2890623880 hasLocation W28906238801 @default.
- W2890623880 hasOpenAccess W2890623880 @default.
- W2890623880 hasPrimaryLocation W28906238801 @default.
- W2890623880 hasRelatedWork W1134996109 @default.
- W2890623880 hasRelatedWork W1498466295 @default.
- W2890623880 hasRelatedWork W2041216149 @default.
- W2890623880 hasRelatedWork W2047844250 @default.
- W2890623880 hasRelatedWork W2110210769 @default.
- W2890623880 hasRelatedWork W2135492658 @default.
- W2890623880 hasRelatedWork W2337756126 @default.
- W2890623880 hasRelatedWork W2345330613 @default.
- W2890623880 hasRelatedWork W2389533588 @default.
- W2890623880 hasRelatedWork W2529384846 @default.
- W2890623880 hasRelatedWork W2560276348 @default.
- W2890623880 hasRelatedWork W2886048695 @default.
- W2890623880 hasRelatedWork W2888022043 @default.
- W2890623880 hasRelatedWork W2913571569 @default.
- W2890623880 hasRelatedWork W2952256331 @default.
- W2890623880 hasRelatedWork W2978620106 @default.
- W2890623880 hasRelatedWork W2980209598 @default.
- W2890623880 hasRelatedWork W3030491708 @default.
- W2890623880 hasRelatedWork W3196917655 @default.
- W2890623880 hasRelatedWork W2943104949 @default.
- W2890623880 hasVolume "1" @default.
- W2890623880 isParatext "false" @default.
- W2890623880 isRetracted "false" @default.
- W2890623880 magId "2890623880" @default.
- W2890623880 workType "article" @default.