Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890624316> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2890624316 abstract "Neuroendocrine tumors of the lung (LNETs) encompass a heterogeneous group of lesions, including tumors with no or low metastatic potential, such as typical (TCs) and atypical (ACs) carcinoids, and highly aggressive neuroendocrine carcinomas. To date, only a few biomarkers with prognostic impact have been identified in LNETs. Previous experimental studies have suggested that the cytokine CXCL12 might have a role in stratifying the outcome of lung cancer as well as LNET patients. However, the reliability of immunohistochemical (IHC) tissue expression of CXCL12 in evaluating the prognosis of resected LNETs is currently not known.Here, we subjected a cohort of 112 resected LNETs specifically enriched for ACs to IHC for CXCL12 and Ki67 using routine procedures. The clinical value of CXCL12 was assessed by applying the Cox proportional-hazards model to overall and disease-free survival rates.We found that CXCL12 was expressed in 8.3 to 38% of LNETs, depending on the different diagnostic categories. Upon survival analysis, when considering the whole cohort, we found that CXCL12-positive cases exhibited shorter disease-free survival rates compared to CXCL12-negative cases. Among ACs, tumors overexpressing CXCL12 showed significantly shorter disease-free survival rates. Finally, we found that the Ki67 index in ACs was higher in the CXCL12-positive cases.CXCL12 immunohistochemistry may serve as a potentially useful tool to better stratify LNETs, and more specifically ACs, in clinical practice." @default.
- W2890624316 created "2018-09-27" @default.
- W2890624316 creator A5005608989 @default.
- W2890624316 creator A5013841162 @default.
- W2890624316 creator A5024230741 @default.
- W2890624316 creator A5026006211 @default.
- W2890624316 creator A5029040081 @default.
- W2890624316 creator A5035721133 @default.
- W2890624316 creator A5048743157 @default.
- W2890624316 creator A5054536265 @default.
- W2890624316 creator A5065261887 @default.
- W2890624316 creator A5088265579 @default.
- W2890624316 date "2018-09-04" @default.
- W2890624316 modified "2023-10-17" @default.
- W2890624316 title "CXCL12 expression is a bona fide predictor of recurrence in lung neuroendocrine tumours; a multicentric study with emphasis on atypical carcinoids - a short report" @default.
- W2890624316 cites W1500037179 @default.
- W2890624316 cites W1953677527 @default.
- W2890624316 cites W1968542980 @default.
- W2890624316 cites W1986239894 @default.
- W2890624316 cites W2075348031 @default.
- W2890624316 cites W2088963481 @default.
- W2890624316 cites W2091205264 @default.
- W2890624316 cites W2109254910 @default.
- W2890624316 cites W2132085487 @default.
- W2890624316 cites W2165896086 @default.
- W2890624316 cites W2293403661 @default.
- W2890624316 cites W2321938170 @default.
- W2890624316 cites W2556183148 @default.
- W2890624316 cites W2606755686 @default.
- W2890624316 cites W2619167255 @default.
- W2890624316 cites W2686978697 @default.
- W2890624316 cites W2755083928 @default.
- W2890624316 doi "https://doi.org/10.1007/s13402-018-0401-9" @default.
- W2890624316 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30182340" @default.
- W2890624316 hasPublicationYear "2018" @default.
- W2890624316 type Work @default.
- W2890624316 sameAs 2890624316 @default.
- W2890624316 citedByCount "2" @default.
- W2890624316 countsByYear W28906243162019 @default.
- W2890624316 countsByYear W28906243162021 @default.
- W2890624316 crossrefType "journal-article" @default.
- W2890624316 hasAuthorship W2890624316A5005608989 @default.
- W2890624316 hasAuthorship W2890624316A5013841162 @default.
- W2890624316 hasAuthorship W2890624316A5024230741 @default.
- W2890624316 hasAuthorship W2890624316A5026006211 @default.
- W2890624316 hasAuthorship W2890624316A5029040081 @default.
- W2890624316 hasAuthorship W2890624316A5035721133 @default.
- W2890624316 hasAuthorship W2890624316A5048743157 @default.
- W2890624316 hasAuthorship W2890624316A5054536265 @default.
- W2890624316 hasAuthorship W2890624316A5065261887 @default.
- W2890624316 hasAuthorship W2890624316A5088265579 @default.
- W2890624316 hasBestOaLocation W28906243162 @default.
- W2890624316 hasConcept C126322002 @default.
- W2890624316 hasConcept C142724271 @default.
- W2890624316 hasConcept C143998085 @default.
- W2890624316 hasConcept C204232928 @default.
- W2890624316 hasConcept C2776256026 @default.
- W2890624316 hasConcept C2779066768 @default.
- W2890624316 hasConcept C2779134260 @default.
- W2890624316 hasConcept C50382708 @default.
- W2890624316 hasConcept C71924100 @default.
- W2890624316 hasConcept C72563966 @default.
- W2890624316 hasConceptScore W2890624316C126322002 @default.
- W2890624316 hasConceptScore W2890624316C142724271 @default.
- W2890624316 hasConceptScore W2890624316C143998085 @default.
- W2890624316 hasConceptScore W2890624316C204232928 @default.
- W2890624316 hasConceptScore W2890624316C2776256026 @default.
- W2890624316 hasConceptScore W2890624316C2779066768 @default.
- W2890624316 hasConceptScore W2890624316C2779134260 @default.
- W2890624316 hasConceptScore W2890624316C50382708 @default.
- W2890624316 hasConceptScore W2890624316C71924100 @default.
- W2890624316 hasConceptScore W2890624316C72563966 @default.
- W2890624316 hasLocation W28906243161 @default.
- W2890624316 hasLocation W28906243162 @default.
- W2890624316 hasLocation W28906243163 @default.
- W2890624316 hasOpenAccess W2890624316 @default.
- W2890624316 hasPrimaryLocation W28906243161 @default.
- W2890624316 hasRelatedWork W1411054225 @default.
- W2890624316 hasRelatedWork W203373507 @default.
- W2890624316 hasRelatedWork W2555516405 @default.
- W2890624316 hasRelatedWork W3104817578 @default.
- W2890624316 hasRelatedWork W3144899533 @default.
- W2890624316 hasRelatedWork W3159490203 @default.
- W2890624316 hasRelatedWork W3193448904 @default.
- W2890624316 hasRelatedWork W3209608268 @default.
- W2890624316 hasRelatedWork W3211406726 @default.
- W2890624316 hasRelatedWork W4280496489 @default.
- W2890624316 isParatext "false" @default.
- W2890624316 isRetracted "false" @default.
- W2890624316 magId "2890624316" @default.
- W2890624316 workType "article" @default.