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• W2890625385 abstract "Approximately 2.5% of all hospitalisations in people with cirrhosis are for spontaneous bacterial peritonitis (SBP). Antibiotics, in addition to supportive treatment (fluid and electrolyte balance, treatment of shock), form the mainstay treatments of SBP. Various antibiotics are available for the treatment of SBP, but there is uncertainty regarding the best antibiotic for SBP.To compare the benefits and harms of different antibiotic treatments for spontaneous bacterial peritonitis (SBP) in people with decompensated liver cirrhosis.We searched CENTRAL, MEDLINE, Embase, Science Citation Index Expanded, World Health Organization International Clinical Trials Registry Platform, and trials registers until November 2018 to identify randomised clinical trials on people with cirrhosis and SBP.We included only randomised clinical trials (irrespective of language, blinding, or publication status) in adults with cirrhosis and SBP. We excluded randomised clinical trials in which participants had previously undergone liver transplantation.Two review authors independently identified eligible trials and collected data. The outcomes for this review included mortality, serious adverse events, any adverse events, resolution of SBP, liver transplantation, and other decompensation events. We performed a network meta-analysis with OpenBUGS using Bayesian methods and calculated the odds ratio, rate ratio, and hazard ratio with 95% credible intervals (CrIs) based on an available-case analysis, according to the National Institute of Health and Care Excellence (NICE) Decision Support Unit guidance.We included a total of 12 trials (1278 participants; 13 antibiotics) in the review. Ten trials (893 participants) were included in one or more outcomes in the review. The trials that provided the information included patients having cirrhosis with or without other features of decompensation of varied aetiologies. The follow-up in the trials ranged from one week to three months. All the trials were at high risk of bias. Only one trial was included under each comparison for most of the outcomes. Because of these reasons, there is very low certainty in all the results. The majority of the randomised clinical trials used third-generation cephalosporins, such as intravenous ceftriaxone, cefotaxime, or ciprofloxacin as one of the interventions.Overall, approximately 75% of trial participants recovered from SBP and 25% of people died within three months. There was no evidence of difference in any of the outcomes for which network meta-analysis was possible: mortality (9 trials; 653 participants), proportion of people with any adverse events (5 trials; 297 participants), resolution of SBP (as per standard definition, 9 trials; 873 participants), or other features of decompensation (6 trials; 535 participants). The effect estimates in the direct comparisons (when available) were very similar to those of network meta-analysis. For the comparisons where network meta-analysis was not possible, there was no evidence of difference in any of the outcomes (proportion of participants with serious adverse events, number of adverse events, and proportion of participants requiring liver transplantation). Due to the wide CrIs and the very low-certainty evidence for all the outcomes, significant benefits or harms of antibiotics are possible.None of the trials reported health-related quality of life, number of serious adverse events, or symptomatic recovery from SBP.the source of funding for two trials were industrial organisations who would benefit from the results of the trial; the source of funding for the remaining 10 trials was unclear.Short-term mortality after SBP is about 25%. There is significant uncertainty about which antibiotic therapy is better in people with SBP.We need adequately powered randomised clinical trials, with adequate blinding, avoiding post-randomisation dropouts (or performing intention-to-treat analysis), and using clinically important outcomes, such as mortality, health-related quality of life, and adverse events." @default.
• W2890625385 created "2018-09-27" @default.
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• W2890625385 date "2019-09-16" @default.
• W2890625385 modified "2023-09-26" @default.
• W2890625385 title "Antibiotic treatment for spontaneous bacterial peritonitis in people with decompensated liver cirrhosis: a network meta-analysis" @default.
• W2890625385 cites W1228830179 @default.
• W2890625385 cites W147080890 @default.
• W2890625385 cites W1512053776 @default.
• W2890625385 cites W1534719948 @default.
• W2890625385 cites W1552630832 @default.
• W2890625385 cites W1573816125 @default.
• W2890625385 cites W1617328014 @default.
• W2890625385 cites W172107136 @default.
• W2890625385 cites W1722539306 @default.
• W2890625385 cites W1940520955 @default.
• W2890625385 cites W1964051982 @default.
• W2890625385 cites W1964489041 @default.
• W2890625385 cites W1964502734 @default.
• W2890625385 cites W1970752949 @default.
• W2890625385 cites W1971895240 @default.
• W2890625385 cites W1987305426 @default.
• W2890625385 cites W1987601386 @default.
• W2890625385 cites W1999154336 @default.
• W2890625385 cites W2010699829 @default.
• W2890625385 cites W2011932878 @default.
• W2890625385 cites W2012654744 @default.
• W2890625385 cites W2020624820 @default.
• W2890625385 cites W2025458886 @default.
• W2890625385 cites W2027675309 @default.
• W2890625385 cites W2031223726 @default.
• W2890625385 cites W2047307236 @default.
• W2890625385 cites W2051564360 @default.
• W2890625385 cites W2057575003 @default.
• W2890625385 cites W2058263296 @default.
• W2890625385 cites W2065384164 @default.
• W2890625385 cites W2066770453 @default.
• W2890625385 cites W2075729861 @default.
• W2890625385 cites W2077653789 @default.
• W2890625385 cites W2081737317 @default.
• W2890625385 cites W2082559972 @default.
• W2890625385 cites W2085803274 @default.
• W2890625385 cites W2091808438 @default.
• W2890625385 cites W2104675861 @default.
• W2890625385 cites W2106051200 @default.
• W2890625385 cites W2108696783 @default.
• W2890625385 cites W2117294447 @default.
• W2890625385 cites W2121796373 @default.
• W2890625385 cites W2124273275 @default.
• W2890625385 cites W2129821518 @default.
• W2890625385 cites W2131206408 @default.
• W2890625385 cites W2131701504 @default.
• W2890625385 cites W2133275424 @default.
• W2890625385 cites W2134338262 @default.
• W2890625385 cites W2144625636 @default.
• W2890625385 cites W2145507336 @default.
• W2890625385 cites W2148609006 @default.
• W2890625385 cites W2149108783 @default.
• W2890625385 cites W2155798268 @default.
• W2890625385 cites W2158011824 @default.
• W2890625385 cites W2159845343 @default.
• W2890625385 cites W2160795579 @default.
• W2890625385 cites W2161817962 @default.
• W2890625385 cites W2166023752 @default.
• W2890625385 cites W2254448168 @default.
• W2890625385 cites W2316788154 @default.
• W2890625385 cites W2410075498 @default.
• W2890625385 cites W2416851684 @default.
• W2890625385 cites W2423391616 @default.
• W2890625385 cites W2531294881 @default.
• W2890625385 cites W2580206496 @default.
• W2890625385 cites W2588681363 @default.
• W2890625385 cites W2612594110 @default.
• W2890625385 cites W262474712 @default.
• W2890625385 cites W2767350488 @default.
• W2890625385 cites W2772571023 @default.
• W2890625385 cites W2781755742 @default.
• W2890625385 cites W2802906787 @default.
• W2890625385 cites W2890625385 @default.
• W2890625385 cites W2891883452 @default.
• W2890625385 cites W2916841405 @default.
• W2890625385 cites W2922171973 @default.
• W2890625385 cites W2943784761 @default.
• W2890625385 cites W305666794 @default.
• W2890625385 cites W36414726 @default.

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