Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890627306> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2890627306 endingPage "1031" @default.
- W2890627306 startingPage "1025" @default.
- W2890627306 abstract "Background. Piezo1/2, a mechanically activated ion channel, is believed to play an important role in bladder carcinogenesis process. Piezo1/2 expression has not been previously reported in urinary bladder carcinoma, and little is known about its significance in bladder carcinogenesis.Objectives. In our study, we aimed to evaluate the Piezo1 and Piezo2 expression as developmental in mouse bladder tissue and bladder cancer tissue of mice and humans.Material and Methods. The detection of developmental expression was performed on P0–P90 days in bladder tissue of Balb/c strain mice. Mice were divided into bladder cancer (n = 40) and control groups (n = 10). Bladder cancer in mice was created by using N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN). In the study, 60 human subjects were included, whose normal tissues were used as controls. After the histopathological evaluation, the expression of Piezo1/2 genes was examined by reverse transcription polymerase chain reaction (RT-PCR) and immunohistochemistry in tumor and normal tissues.Results. In developmental period of the mice, Piezo1 expression increased on days 21 and 90, whereas Piezo2 expression increased on day 7 and decreased on day 90 in mouse bladder tissues. There was a significant increase in the expression of Piezo1/2 in both cancer groups compared to the control group. Piezo1 expression was significantly increased at tumor size, stage and grade. Piezo2 expression was upregulated in high grade tumors in human subjects.Conclusion. The developmental changes of Piezo expression on specific days demonstrate the role of these channels in bladder cancer development. The dysfunction of Piezo1/2 expression may contribute to the carcinogenesis of bladder cancer by causing proliferative changes and angiogenesis. The expression of Piezo1/2 can provide new prognostic information for disease progression." @default.
- W2890627306 created "2018-09-27" @default.
- W2890627306 creator A5016027689 @default.
- W2890627306 creator A5029841587 @default.
- W2890627306 creator A5050895409 @default.
- W2890627306 creator A5071573977 @default.
- W2890627306 creator A5073371125 @default.
- W2890627306 creator A5080306709 @default.
- W2890627306 date "2018-08-31" @default.
- W2890627306 modified "2023-10-14" @default.
- W2890627306 title "The increased expression of Piezo1 and Piezo2 ion channels in human and mouse bladder carcinoma" @default.
- W2890627306 doi "https://doi.org/10.17219/acem/71080" @default.
- W2890627306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30010255" @default.
- W2890627306 hasPublicationYear "2018" @default.
- W2890627306 type Work @default.
- W2890627306 sameAs 2890627306 @default.
- W2890627306 citedByCount "32" @default.
- W2890627306 countsByYear W28906273062019 @default.
- W2890627306 countsByYear W28906273062020 @default.
- W2890627306 countsByYear W28906273062021 @default.
- W2890627306 countsByYear W28906273062022 @default.
- W2890627306 countsByYear W28906273062023 @default.
- W2890627306 crossrefType "journal-article" @default.
- W2890627306 hasAuthorship W2890627306A5016027689 @default.
- W2890627306 hasAuthorship W2890627306A5029841587 @default.
- W2890627306 hasAuthorship W2890627306A5050895409 @default.
- W2890627306 hasAuthorship W2890627306A5071573977 @default.
- W2890627306 hasAuthorship W2890627306A5073371125 @default.
- W2890627306 hasAuthorship W2890627306A5080306709 @default.
- W2890627306 hasBestOaLocation W28906273061 @default.
- W2890627306 hasConcept C104317684 @default.
- W2890627306 hasConcept C121608353 @default.
- W2890627306 hasConcept C126322002 @default.
- W2890627306 hasConcept C142724271 @default.
- W2890627306 hasConcept C150194340 @default.
- W2890627306 hasConcept C170493617 @default.
- W2890627306 hasConcept C204232928 @default.
- W2890627306 hasConcept C2777546739 @default.
- W2890627306 hasConcept C2779762690 @default.
- W2890627306 hasConcept C2780352672 @default.
- W2890627306 hasConcept C2780785647 @default.
- W2890627306 hasConcept C4001165 @default.
- W2890627306 hasConcept C4692481 @default.
- W2890627306 hasConcept C48023723 @default.
- W2890627306 hasConcept C50254741 @default.
- W2890627306 hasConcept C54355233 @default.
- W2890627306 hasConcept C555283112 @default.
- W2890627306 hasConcept C71924100 @default.
- W2890627306 hasConcept C86803240 @default.
- W2890627306 hasConceptScore W2890627306C104317684 @default.
- W2890627306 hasConceptScore W2890627306C121608353 @default.
- W2890627306 hasConceptScore W2890627306C126322002 @default.
- W2890627306 hasConceptScore W2890627306C142724271 @default.
- W2890627306 hasConceptScore W2890627306C150194340 @default.
- W2890627306 hasConceptScore W2890627306C170493617 @default.
- W2890627306 hasConceptScore W2890627306C204232928 @default.
- W2890627306 hasConceptScore W2890627306C2777546739 @default.
- W2890627306 hasConceptScore W2890627306C2779762690 @default.
- W2890627306 hasConceptScore W2890627306C2780352672 @default.
- W2890627306 hasConceptScore W2890627306C2780785647 @default.
- W2890627306 hasConceptScore W2890627306C4001165 @default.
- W2890627306 hasConceptScore W2890627306C4692481 @default.
- W2890627306 hasConceptScore W2890627306C48023723 @default.
- W2890627306 hasConceptScore W2890627306C50254741 @default.
- W2890627306 hasConceptScore W2890627306C54355233 @default.
- W2890627306 hasConceptScore W2890627306C555283112 @default.
- W2890627306 hasConceptScore W2890627306C71924100 @default.
- W2890627306 hasConceptScore W2890627306C86803240 @default.
- W2890627306 hasIssue "8" @default.
- W2890627306 hasLocation W28906273061 @default.
- W2890627306 hasLocation W28906273062 @default.
- W2890627306 hasOpenAccess W2890627306 @default.
- W2890627306 hasPrimaryLocation W28906273061 @default.
- W2890627306 hasRelatedWork W1986212507 @default.
- W2890627306 hasRelatedWork W1987124039 @default.
- W2890627306 hasRelatedWork W2036169046 @default.
- W2890627306 hasRelatedWork W2048172397 @default.
- W2890627306 hasRelatedWork W2049619530 @default.
- W2890627306 hasRelatedWork W2103585434 @default.
- W2890627306 hasRelatedWork W2358565899 @default.
- W2890627306 hasRelatedWork W2742519752 @default.
- W2890627306 hasRelatedWork W2890627306 @default.
- W2890627306 hasRelatedWork W4224287592 @default.
- W2890627306 hasVolume "27" @default.
- W2890627306 isParatext "false" @default.
- W2890627306 isRetracted "false" @default.
- W2890627306 magId "2890627306" @default.
- W2890627306 workType "article" @default.