Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890628594> ?p ?o ?g. }
- W2890628594 endingPage "6289" @default.
- W2890628594 startingPage "6282" @default.
- W2890628594 abstract "As the hepatitis B virus is widely spread and responsible for considerable morbidity and mortality, WHO recommends vaccination from infancy to reduce acute infection and chronic carriers. However, current subunit vaccines are not 100% efficacious and leave 5-10% of recipients unprotected.To evaluate immune responses after Engerix-B vaccination, we determined, using mRNA-sequencing, whole blood early gene expression signatures before, at day 3 and day 7 after the first dose and correlated this with the resulting antibody titer after two vaccine doses.Our results indicate that immune related genes are differentially expressed in responders mostly at day 3 and in non-responders mostly at day 7. The most remarkable difference between responders and non-responders were the differentially expressed genes before vaccination. The granulin precursor gene (GRN) was significantly downregulated in responders while upregulated in non-responders at day 0. Furthermore, absolute granulocytes numbers were significantly higher in non-responders at day 0.The non-responders already showed an activated state of the immune system before vaccination. Furthermore, after vaccination, they exhibited a delayed and partial immune response in comparison to the responders. Our data may indicate that the baseline and untriggered immune system can influence the response upon hepatitis B vaccination." @default.
- W2890628594 created "2018-09-27" @default.
- W2890628594 creator A5014840063 @default.
- W2890628594 creator A5017109116 @default.
- W2890628594 creator A5024401144 @default.
- W2890628594 creator A5024445778 @default.
- W2890628594 creator A5032533861 @default.
- W2890628594 creator A5037454723 @default.
- W2890628594 creator A5042663607 @default.
- W2890628594 creator A5043815279 @default.
- W2890628594 creator A5045665405 @default.
- W2890628594 creator A5057452087 @default.
- W2890628594 creator A5058655705 @default.
- W2890628594 creator A5059507519 @default.
- W2890628594 creator A5069580321 @default.
- W2890628594 creator A5071339127 @default.
- W2890628594 creator A5086586349 @default.
- W2890628594 date "2018-10-01" @default.
- W2890628594 modified "2023-10-16" @default.
- W2890628594 title "Transcriptome profiling in blood before and after hepatitis B vaccination shows significant differences in gene expression between responders and non-responders" @default.
- W2890628594 cites W1507563442 @default.
- W2890628594 cites W1538006085 @default.
- W2890628594 cites W1969218538 @default.
- W2890628594 cites W1971147944 @default.
- W2890628594 cites W1972719726 @default.
- W2890628594 cites W1975824915 @default.
- W2890628594 cites W1976916333 @default.
- W2890628594 cites W1982855701 @default.
- W2890628594 cites W1986808693 @default.
- W2890628594 cites W2010218724 @default.
- W2890628594 cites W2010258002 @default.
- W2890628594 cites W2037665605 @default.
- W2890628594 cites W2046700952 @default.
- W2890628594 cites W2059980695 @default.
- W2890628594 cites W2078184739 @default.
- W2890628594 cites W2090859505 @default.
- W2890628594 cites W2092563148 @default.
- W2890628594 cites W2103749584 @default.
- W2890628594 cites W2106391655 @default.
- W2890628594 cites W2118306668 @default.
- W2890628594 cites W2134655578 @default.
- W2890628594 cites W2144902263 @default.
- W2890628594 cites W2153060595 @default.
- W2890628594 cites W2229921221 @default.
- W2890628594 cites W2304043385 @default.
- W2890628594 cites W2337394308 @default.
- W2890628594 cites W2914556923 @default.
- W2890628594 cites W4210511442 @default.
- W2890628594 doi "https://doi.org/10.1016/j.vaccine.2018.09.001" @default.
- W2890628594 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30205979" @default.
- W2890628594 hasPublicationYear "2018" @default.
- W2890628594 type Work @default.
- W2890628594 sameAs 2890628594 @default.
- W2890628594 citedByCount "36" @default.
- W2890628594 countsByYear W28906285942019 @default.
- W2890628594 countsByYear W28906285942020 @default.
- W2890628594 countsByYear W28906285942021 @default.
- W2890628594 countsByYear W28906285942022 @default.
- W2890628594 countsByYear W28906285942023 @default.
- W2890628594 crossrefType "journal-article" @default.
- W2890628594 hasAuthorship W2890628594A5014840063 @default.
- W2890628594 hasAuthorship W2890628594A5017109116 @default.
- W2890628594 hasAuthorship W2890628594A5024401144 @default.
- W2890628594 hasAuthorship W2890628594A5024445778 @default.
- W2890628594 hasAuthorship W2890628594A5032533861 @default.
- W2890628594 hasAuthorship W2890628594A5037454723 @default.
- W2890628594 hasAuthorship W2890628594A5042663607 @default.
- W2890628594 hasAuthorship W2890628594A5043815279 @default.
- W2890628594 hasAuthorship W2890628594A5045665405 @default.
- W2890628594 hasAuthorship W2890628594A5057452087 @default.
- W2890628594 hasAuthorship W2890628594A5058655705 @default.
- W2890628594 hasAuthorship W2890628594A5059507519 @default.
- W2890628594 hasAuthorship W2890628594A5069580321 @default.
- W2890628594 hasAuthorship W2890628594A5071339127 @default.
- W2890628594 hasAuthorship W2890628594A5086586349 @default.
- W2890628594 hasBestOaLocation W28906285942 @default.
- W2890628594 hasConcept C104317684 @default.
- W2890628594 hasConcept C150194340 @default.
- W2890628594 hasConcept C159047783 @default.
- W2890628594 hasConcept C159654299 @default.
- W2890628594 hasConcept C162317418 @default.
- W2890628594 hasConcept C18431079 @default.
- W2890628594 hasConcept C203014093 @default.
- W2890628594 hasConcept C22070199 @default.
- W2890628594 hasConcept C2522874641 @default.
- W2890628594 hasConcept C2777382497 @default.
- W2890628594 hasConcept C2777410769 @default.
- W2890628594 hasConcept C2780593183 @default.
- W2890628594 hasConcept C2781037505 @default.
- W2890628594 hasConcept C32611913 @default.
- W2890628594 hasConcept C55493867 @default.
- W2890628594 hasConcept C71924100 @default.
- W2890628594 hasConcept C86803240 @default.
- W2890628594 hasConcept C8891405 @default.
- W2890628594 hasConceptScore W2890628594C104317684 @default.
- W2890628594 hasConceptScore W2890628594C150194340 @default.
- W2890628594 hasConceptScore W2890628594C159047783 @default.
- W2890628594 hasConceptScore W2890628594C159654299 @default.