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- W2890631177 abstract "Molecular BiologyDamage to DNA genomes is normally thought to be repaired with DNA. Pryor et al. now describe a clear exception (see the Perspective by Modesti). They found that RNA is routinely incorporated during the repair of DNA double-strand breaks through the mammalian nonhomologous end–joining (NHEJ) pathway. In a variety of contexts, including V(D)J recombination and Cas9-induced genome engineering, two “DNA” polymerases specific to NHEJ preferentially added RNA in cells. These RNA additions facilitated the critical step of ligation and were later replaced by DNA to complete the NHEJ repair process.Science , this issue p. [1126][1]; see also p. [1069][2] [1]: /lookup/doi/10.1126/science.aat2477 [2]: /lookup/doi/10.1126/science.aau9194" @default.
- W2890631177 created "2018-09-27" @default.
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- W2890631177 date "2018-09-13" @default.
- W2890631177 modified "2023-09-24" @default.
- W2890631177 title "RNA takes over DNA repair" @default.
- W2890631177 doi "https://doi.org/10.1126/science.361.6407.1083-f" @default.
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