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• W2890631394 abstract "Abstract Background The frequency of occurrence of neuroendocrine carcinoma (NEC) in the upper gastrointestinal tract is low, and especially large cell neuroendocrine carcinoma (LCNEC) is extremely rare disease. We report a case of LCNEC of the esophagogastric junction with relapse-free survival in 1 year and 3 months after surgical treatment. Methods An 81 - year—old Japanese man was referred to our hospital because of a semicircular ulcerative lesion in the esophagogastric junction (EGJ) by esophagogastroduodenoscopy of routine medical checkup. Biopsy from the lesion showed proliferation of tumor cells with clear nuclear bodies and irregular nuclei. Immunohistochemistry (IHC) demonstrated weakly positive staining of AE1/AE3, and CD3, CD20, S-100 and HMB 45 were negative. Computed tomography (CT) revealed a thickened wall of the EGJ and a lymphadenopathy of the cardiac node without any metastases to other organs. The patient was diagnosed with carcinoma in EJG, Stage III T3N1M0. We performed thoracoscopic esophagectomy with two-filed lymphadenectomy. Results Macroscopically, the ulcerative tumor measured 55 × 50mm invaded to the adventitia and was approximately centered in the EGJ. Histologically, the tumor cells showed large nuclei with highly frequent mitoses. IHC revealed that tumor was LCNEC positive for synaptophysin. One lymph node metastasis was found among 39 dissected lymph nodes. Finally, the pathological stage was T3N1M0, IIIA. On postoperative day 7, we performed the drainage for intra-abdominal abscess. He was discharged on postoperative day 44. Adjuvant chemotherapy was not performed, because the patient refused it. He was well and had no evidence of recurrence 15 months after surgery. Conclusion LCNECs of the esophagus or stomach are very rare but highly malignant tumors. It is expected that the number of reports of LCNEC in the upper gastrointestinal tract will increase. It is necessary to collect information on more cases to improve prognosis and to establish appropriate treatment guidelines. Disclosure All authors have declared no conflicts of interest." @default.
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• W2890631394 date "2018-09-01" @default.
• W2890631394 modified "2023-09-27" @default.
• W2890631394 title "PS02.193: A CASE OF LARGE CELL NEUROENDOCRINE CARCINOMA OF THE ESOPHAGOGASTRIC JUNCTION" @default.
• W2890631394 doi "https://doi.org/10.1093/dote/doy089.ps02.193" @default.
• W2890631394 hasPublicationYear "2018" @default.
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