Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890633076> ?p ?o ?g. }
- W2890633076 endingPage "18" @default.
- W2890633076 startingPage "11" @default.
- W2890633076 abstract "A high number of illnesses and disorders are connected to zinc deficiency. Equally, T cell polarization and a balance between different T helper (Th) cell subsets are essential. Therefore, in this study, the influence of zinc deficiency on T cell polarization and on respective signaling pathways was investigated. We uncovered a significantly increased number of regulatory T cells (Treg) and Th17 cells in expanded T cells during zinc deficiency after 3 days of combined treatment with IL-2 and TGF-β1 (Treg) or IL-6 and TGF-β1 (Th17). No difference in Th1 and Th2 cell polarization between zinc-deficient and zinc-adequate status was prominent. On the molecular level, Smad signaling was significantly enhanced by stimulation with TGF-β1/IL-6 during zinc deficiency compared to adequate zinc condition. This represents an explanation for the elevated Th17 cell numbers associated with autoimmune disease especially during zinc deficiency. Moreover, Treg cell numbers are increased during zinc deficiency as well. However, those cells might be nonfunctional since a lower expression of miR-146a was uncovered compared to normal zinc concentrations. In summary, an adequate zinc homeostasis is fundamental to slow down or probably stop the progression of autoimmune diseases and infections. Therefore, supplementing zinc might be a therapeutic approach to dampen autoimmune diseases connected to Th17 cells." @default.
- W2890633076 created "2018-09-27" @default.
- W2890633076 creator A5049326372 @default.
- W2890633076 creator A5050192465 @default.
- W2890633076 creator A5069466878 @default.
- W2890633076 creator A5074670475 @default.
- W2890633076 creator A5083811645 @default.
- W2890633076 date "2019-01-01" @default.
- W2890633076 modified "2023-10-16" @default.
- W2890633076 title "Zinc deficiency drives Th17 polarization and promotes loss of Treg cell function" @default.
- W2890633076 cites W1499097678 @default.
- W2890633076 cites W1862295486 @default.
- W2890633076 cites W190836243 @default.
- W2890633076 cites W1970125094 @default.
- W2890633076 cites W1970271735 @default.
- W2890633076 cites W1971756280 @default.
- W2890633076 cites W1971861118 @default.
- W2890633076 cites W1982768262 @default.
- W2890633076 cites W1984513006 @default.
- W2890633076 cites W1988649673 @default.
- W2890633076 cites W1993284336 @default.
- W2890633076 cites W1996270406 @default.
- W2890633076 cites W2001233456 @default.
- W2890633076 cites W2003877633 @default.
- W2890633076 cites W2007096141 @default.
- W2890633076 cites W2009143592 @default.
- W2890633076 cites W2013422007 @default.
- W2890633076 cites W2014750930 @default.
- W2890633076 cites W2017425827 @default.
- W2890633076 cites W2020427318 @default.
- W2890633076 cites W2022088528 @default.
- W2890633076 cites W2025920337 @default.
- W2890633076 cites W2030366802 @default.
- W2890633076 cites W2033568629 @default.
- W2890633076 cites W2036831850 @default.
- W2890633076 cites W2050552472 @default.
- W2890633076 cites W2050580942 @default.
- W2890633076 cites W2055082742 @default.
- W2890633076 cites W2055115911 @default.
- W2890633076 cites W2072659663 @default.
- W2890633076 cites W2074632761 @default.
- W2890633076 cites W2075295018 @default.
- W2890633076 cites W2089455607 @default.
- W2890633076 cites W2091413141 @default.
- W2890633076 cites W2092430803 @default.
- W2890633076 cites W2101662524 @default.
- W2890633076 cites W2103254653 @default.
- W2890633076 cites W2107277218 @default.
- W2890633076 cites W2113989947 @default.
- W2890633076 cites W2119163321 @default.
- W2890633076 cites W2121765586 @default.
- W2890633076 cites W2128856901 @default.
- W2890633076 cites W2129406210 @default.
- W2890633076 cites W2129991688 @default.
- W2890633076 cites W2132557486 @default.
- W2890633076 cites W2135858383 @default.
- W2890633076 cites W2138249160 @default.
- W2890633076 cites W2152122395 @default.
- W2890633076 cites W2152819244 @default.
- W2890633076 cites W2166916498 @default.
- W2890633076 cites W2172819540 @default.
- W2890633076 cites W2182218920 @default.
- W2890633076 cites W2241884422 @default.
- W2890633076 cites W2328414487 @default.
- W2890633076 cites W2331809928 @default.
- W2890633076 cites W2417887013 @default.
- W2890633076 cites W2462253112 @default.
- W2890633076 cites W2531906780 @default.
- W2890633076 cites W2545453468 @default.
- W2890633076 cites W2569553138 @default.
- W2890633076 cites W2681612409 @default.
- W2890633076 cites W2770914202 @default.
- W2890633076 cites W2786229868 @default.
- W2890633076 doi "https://doi.org/10.1016/j.jnutbio.2018.09.011" @default.
- W2890633076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30316032" @default.
- W2890633076 hasPublicationYear "2019" @default.
- W2890633076 type Work @default.
- W2890633076 sameAs 2890633076 @default.
- W2890633076 citedByCount "24" @default.
- W2890633076 countsByYear W28906330762018 @default.
- W2890633076 countsByYear W28906330762019 @default.
- W2890633076 countsByYear W28906330762020 @default.
- W2890633076 countsByYear W28906330762021 @default.
- W2890633076 countsByYear W28906330762022 @default.
- W2890633076 countsByYear W28906330762023 @default.
- W2890633076 crossrefType "journal-article" @default.
- W2890633076 hasAuthorship W2890633076A5049326372 @default.
- W2890633076 hasAuthorship W2890633076A5050192465 @default.
- W2890633076 hasAuthorship W2890633076A5069466878 @default.
- W2890633076 hasAuthorship W2890633076A5074670475 @default.
- W2890633076 hasAuthorship W2890633076A5083811645 @default.
- W2890633076 hasConcept C134018914 @default.
- W2890633076 hasConcept C1491633281 @default.
- W2890633076 hasConcept C178790620 @default.
- W2890633076 hasConcept C185592680 @default.
- W2890633076 hasConcept C203014093 @default.
- W2890633076 hasConcept C2776090121 @default.
- W2890633076 hasConcept C2776928490 @default.