FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890634550> ?p ?o ?g. }

• W2890634550 abstract "Autoimmune rheumatic lesions are often characterised by the immune cell recruitment including B lymphocytes and the presence of reactive oxygen species (ROS), which increase antioxidant gene transcription via nuclear factor (erythroid-derived 2)-like 2 (Nrf2). Spleen tyrosine kinase (Syk) has a major role in the signal transmission of all haematopoietic lineage cells including B/T cells, mast cells, and macrophages. In this study, we investigated whether B cell survival is regulated by Nrf2 via ROS-mediated Syk activation in WiL2-NS human B lymphoblast cells. When WiL2-NS cells were incubated with 1% foetal bovine serum (FBS), the survival rate and mitochondrial membrane potential (MMP) were reduced. In addition, 1% FBS increased caspase 3 activity, cytochrome C release, nuclear localisation of Nrf2, and ROS production. N-acetylcysteine attenuated ROS production and nuclear translocation of Nrf2. It also inhibited cell death, caspase 3 activation, MMP collapse, and cytochrome C release. Results from the 1% FBS treatment were consistent with those of H2O2 treatment. Syk phosphorylation at tyrosine 525/526 was increased by incubation with 1% FBS or treatment with 100 µM H2O2. Nuclear translocation of Nrf2 by H2O2 was inhibited by treatment with BAY61-3606, a Syk inhibitor. BAY61-3606 also promoted MMP collapse, cytochrome C release, caspase 3 activation, and cell death. Taken together, these results implicate that Syk controls oxidative stress-induced human B cell death via nuclear translocation of Nrf2 and MMP collapse. These results suggest that Syk is a novel regulator of Nrf2 activation." @default.
• W2890634550 created "2018-09-27" @default.
• W2890634550 creator A5066250135 @default.
• W2890634550 creator A5069679336 @default.
• W2890634550 creator A5070645732 @default.
• W2890634550 date "2018-09-02" @default.
• W2890634550 modified "2023-09-24" @default.
• W2890634550 title "Spleen tyrosine kinase-dependent Nrf2 activation regulates oxidative stress-induced cell death in WiL2-NS human B lymphoblasts" @default.
• W2890634550 cites W1235720436 @default.
• W2890634550 cites W1734082729 @default.
• W2890634550 cites W1966948511 @default.
• W2890634550 cites W1970167015 @default.
• W2890634550 cites W1970663543 @default.
• W2890634550 cites W1973379522 @default.
• W2890634550 cites W1974934658 @default.
• W2890634550 cites W1977128317 @default.
• W2890634550 cites W1980739328 @default.
• W2890634550 cites W1981705852 @default.
• W2890634550 cites W1986794875 @default.
• W2890634550 cites W1999274929 @default.
• W2890634550 cites W2000017694 @default.
• W2890634550 cites W2005857763 @default.
• W2890634550 cites W2011826815 @default.
• W2890634550 cites W2016967137 @default.
• W2890634550 cites W2017341404 @default.
• W2890634550 cites W2022900996 @default.
• W2890634550 cites W2031307848 @default.
• W2890634550 cites W2031646822 @default.
• W2890634550 cites W2038691856 @default.
• W2890634550 cites W2053047691 @default.
• W2890634550 cites W2055353130 @default.
• W2890634550 cites W2062845561 @default.
• W2890634550 cites W2072462194 @default.
• W2890634550 cites W2076482516 @default.
• W2890634550 cites W2084141237 @default.
• W2890634550 cites W2084501277 @default.
• W2890634550 cites W2087947799 @default.
• W2890634550 cites W2092901424 @default.
• W2890634550 cites W2093009907 @default.
• W2890634550 cites W2095447228 @default.
• W2890634550 cites W2105735844 @default.
• W2890634550 cites W2117551116 @default.
• W2890634550 cites W2117800935 @default.
• W2890634550 cites W2130100570 @default.
• W2890634550 cites W2133168488 @default.
• W2890634550 cites W2137269303 @default.
• W2890634550 cites W2141061805 @default.
• W2890634550 cites W2142187278 @default.
• W2890634550 cites W2143364298 @default.
• W2890634550 cites W2146558971 @default.
• W2890634550 cites W2146894441 @default.
• W2890634550 cites W2147924866 @default.
• W2890634550 cites W2155383113 @default.
• W2890634550 cites W2159725132 @default.
• W2890634550 cites W2164944202 @default.
• W2890634550 cites W2324822262 @default.
• W2890634550 cites W2417535489 @default.
• W2890634550 cites W2783574761 @default.
• W2890634550 doi "https://doi.org/10.1080/10715762.2018.1505044" @default.
• W2890634550 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30203714" @default.
• W2890634550 hasPublicationYear "2018" @default.
• W2890634550 type Work @default.
• W2890634550 sameAs 2890634550 @default.
• W2890634550 citedByCount "8" @default.
• W2890634550 countsByYear W28906345502020 @default.
• W2890634550 countsByYear W28906345502021 @default.
• W2890634550 countsByYear W28906345502022 @default.
• W2890634550 countsByYear W28906345502023 @default.
• W2890634550 crossrefType "journal-article" @default.
• W2890634550 hasAuthorship W2890634550A5066250135 @default.
• W2890634550 hasAuthorship W2890634550A5069679336 @default.
• W2890634550 hasAuthorship W2890634550A5070645732 @default.
• W2890634550 hasConcept C153911025 @default.
• W2890634550 hasConcept C185592680 @default.
• W2890634550 hasConcept C190283241 @default.
• W2890634550 hasConcept C2776151105 @default.
• W2890634550 hasConcept C2777553839 @default.
• W2890634550 hasConcept C31573885 @default.
• W2890634550 hasConcept C35174551 @default.
• W2890634550 hasConcept C42362537 @default.
• W2890634550 hasConcept C55493867 @default.
• W2890634550 hasConcept C62478195 @default.
• W2890634550 hasConcept C86803240 @default.
• W2890634550 hasConcept C95444343 @default.
• W2890634550 hasConceptScore W2890634550C153911025 @default.
• W2890634550 hasConceptScore W2890634550C185592680 @default.
• W2890634550 hasConceptScore W2890634550C190283241 @default.
• W2890634550 hasConceptScore W2890634550C2776151105 @default.
• W2890634550 hasConceptScore W2890634550C2777553839 @default.
• W2890634550 hasConceptScore W2890634550C31573885 @default.
• W2890634550 hasConceptScore W2890634550C35174551 @default.
• W2890634550 hasConceptScore W2890634550C42362537 @default.
• W2890634550 hasConceptScore W2890634550C55493867 @default.
• W2890634550 hasConceptScore W2890634550C62478195 @default.
• W2890634550 hasConceptScore W2890634550C86803240 @default.
• W2890634550 hasConceptScore W2890634550C95444343 @default.
• W2890634550 hasFunder F4320320671 @default.
• W2890634550 hasFunder F4320322349 @default.
• W2890634550 hasLocation W28906345501 @default.
• W2890634550 hasLocation W28906345502 @default.

• next