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- W2890634706 abstract "Malonyl-CoA is a central metabolite in fatty acid biochemistry. It is the rate-determining intermediate in fatty acid synthesis but is also an allosteric inhibitor of the rate-setting step in mitochondrial long-chain fatty acid oxidation. While these canonical cytoplasmic roles of malonyl-CoA have been well described, malonyl-CoA can also be generated within the mitochondrial matrix by an alternative pathway: the ATP-dependent ligation of malonate to Coenzyme A by the malonyl-CoA synthetase ACSF3. Malonate, a competitive inhibitor of succinate dehydrogenase of the TCA cycle, is a potent inhibitor of mitochondrial respiration. A major role for ACSF3 is to provide a metabolic pathway for the clearance of malonate by the generation of malonyl-CoA, which can then be decarboxylated to acetyl-CoA by malonyl-CoA decarboxylase. Additionally, ACSF3-derived malonyl-CoA can be used to malonylate lysine residues on proteins within the matrix of mitochondria, possibly adding another regulatory layer to post-translational control of mitochondrial metabolism. The discovery of ACSF3-mediated generation of malonyl-CoA defines a new mitochondrial metabolic pathway and raises new questions about how the metabolic fates of this multifunctional metabolite intersect with mitochondrial metabolism." @default.
- W2890634706 created "2018-09-27" @default.
- W2890634706 creator A5043042092 @default.
- W2890634706 creator A5071347274 @default.
- W2890634706 date "2019-01-01" @default.
- W2890634706 modified "2023-10-01" @default.
- W2890634706 title "Role of the malonyl-CoA synthetase ACSF3 in mitochondrial metabolism" @default.
- W2890634706 cites W129702359 @default.
- W2890634706 cites W133504810 @default.
- W2890634706 cites W1541962917 @default.
- W2890634706 cites W1558601380 @default.
- W2890634706 cites W16209203 @default.
- W2890634706 cites W174530313 @default.
- W2890634706 cites W1897914709 @default.
- W2890634706 cites W1954914035 @default.
- W2890634706 cites W1955146052 @default.
- W2890634706 cites W1966363074 @default.
- W2890634706 cites W1969469789 @default.
- W2890634706 cites W1970020574 @default.
- W2890634706 cites W1974020172 @default.
- W2890634706 cites W1979315905 @default.
- W2890634706 cites W1982126966 @default.
- W2890634706 cites W1982218364 @default.
- W2890634706 cites W1984658022 @default.
- W2890634706 cites W1989717261 @default.
- W2890634706 cites W1990740519 @default.
- W2890634706 cites W1990852009 @default.
- W2890634706 cites W1995630908 @default.
- W2890634706 cites W2001828434 @default.
- W2890634706 cites W2001986473 @default.
- W2890634706 cites W2002935961 @default.
- W2890634706 cites W2005033942 @default.
- W2890634706 cites W2007486805 @default.
- W2890634706 cites W2016255597 @default.
- W2890634706 cites W2016752484 @default.
- W2890634706 cites W2020285011 @default.
- W2890634706 cites W2033296726 @default.
- W2890634706 cites W2033910563 @default.
- W2890634706 cites W2034438393 @default.
- W2890634706 cites W2034590888 @default.
- W2890634706 cites W2037877475 @default.
- W2890634706 cites W2042033533 @default.
- W2890634706 cites W2042450476 @default.
- W2890634706 cites W2051278797 @default.
- W2890634706 cites W2051554319 @default.
- W2890634706 cites W2054248098 @default.
- W2890634706 cites W2055061083 @default.
- W2890634706 cites W2059750004 @default.
- W2890634706 cites W2061725130 @default.
- W2890634706 cites W2063452056 @default.
- W2890634706 cites W2065937213 @default.
- W2890634706 cites W2067289453 @default.
- W2890634706 cites W2072676874 @default.
- W2890634706 cites W2084320367 @default.
- W2890634706 cites W2085578725 @default.
- W2890634706 cites W2085853684 @default.
- W2890634706 cites W2086825927 @default.
- W2890634706 cites W2088511656 @default.
- W2890634706 cites W2090008797 @default.
- W2890634706 cites W2090038499 @default.
- W2890634706 cites W2092786020 @default.
- W2890634706 cites W2105770392 @default.
- W2890634706 cites W2107081864 @default.
- W2890634706 cites W2109069233 @default.
- W2890634706 cites W2110549950 @default.
- W2890634706 cites W2111316498 @default.
- W2890634706 cites W2112676571 @default.
- W2890634706 cites W2116338621 @default.
- W2890634706 cites W2119861196 @default.
- W2890634706 cites W2121046220 @default.
- W2890634706 cites W2125404675 @default.
- W2890634706 cites W2127498339 @default.
- W2890634706 cites W2134580783 @default.
- W2890634706 cites W2135110132 @default.
- W2890634706 cites W2138012016 @default.
- W2890634706 cites W2141682571 @default.
- W2890634706 cites W2144633939 @default.
- W2890634706 cites W2158950938 @default.
- W2890634706 cites W2162002416 @default.
- W2890634706 cites W2169880855 @default.
- W2890634706 cites W2314450621 @default.
- W2890634706 cites W2319441209 @default.
- W2890634706 cites W2560726500 @default.
- W2890634706 cites W2584672860 @default.
- W2890634706 cites W2604275396 @default.
- W2890634706 cites W2604947595 @default.
- W2890634706 cites W2610983028 @default.
- W2890634706 cites W2740414557 @default.
- W2890634706 cites W2761618104 @default.
- W2890634706 cites W2772709248 @default.
- W2890634706 cites W2787693514 @default.
- W2890634706 cites W2792904491 @default.
- W2890634706 cites W2806626431 @default.
- W2890634706 cites W2807780796 @default.
- W2890634706 cites W2884792430 @default.
- W2890634706 cites W4242108613 @default.
- W2890634706 doi "https://doi.org/10.1016/j.jbior.2018.09.002" @default.
- W2890634706 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6347522" @default.