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- W2890638500 endingPage "166" @default.
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- W2890638500 abstract "ORAI1 constitutes the pore-forming subunit of the calcium release-activated calcium (CRAC) channel, a prototypical store-operated channel that is essential for the activation of cells of the immune system. Here we describe a convenient yet powerful cross-linking approach to examine the pore architecture of CRAC channels using ORAI1 proteins engineered to contain one or two cysteine residues. The generalizable cross-linking in situ approach can also be readily extended to study other integral membrane proteins expressed in various types of cells." @default.
- W2890638500 created "2018-09-27" @default.
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- W2890638500 date "2018-01-01" @default.
- W2890638500 modified "2023-10-15" @default.
- W2890638500 title "Engineered Cross-Linking to Study the Pore Architecture of the CRAC Channel" @default.
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- W2890638500 doi "https://doi.org/10.1007/978-1-4939-8704-7_13" @default.
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