FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890639359> ?p ?o ?g. }

• W2890639359 endingPage "720" @default.
• W2890639359 startingPage "711" @default.
• W2890639359 abstract "Childhood trauma and neglect influence emotional development and increase the risk for and severity of mental illness. Women have a heightened susceptibility to the effects of early life stress (ELS) and are twice as likely as men to develop debilitating, stress-associated disorders later in life, such as major depressive disorder (MDD). Until now, mouse models of depression have been largely unsuccessful at replicating the diverse symptomatology of this disease and the sex bias in vulnerability. From P4 to P11, a limited bedding model that leads to fragmented maternal care, was used to induce ELS. Early adolescent and young adult mice were tested on an array of assays to test for depressive-like behavior. This included our newly developed automated home cage behavioral recognition system, where the home cage behavior of ELS and control mice could be monitored over a continuous 5-10 day span. ELS females, but not males, exhibited depressive-like behaviors on traditional assays. These effects emerged during adolescence and became more severe in adulthood. Using the novel home cage video monitoring method, we identified robust and continuous markers of depressive-like pathology in ELS females that phenocopy many of the behavioral characteristics of depression in humans. ELS effects on home cage behavior were rapidly rescued by ketamine, a fast-acting antidepressant. Together, these findings highlight that limited bedding ELS (1) produces an early emerging, female-specific depressive phenotype that responds to a fast-acting antidepressant and (2) this model has the potential to inform sex-selective risk for the development of stress-induced mental illness." @default.
• W2890639359 created "2018-09-27" @default.
• W2890639359 creator A5009347272 @default.
• W2890639359 creator A5013925344 @default.
• W2890639359 creator A5018626055 @default.
• W2890639359 creator A5040848176 @default.
• W2890639359 creator A5044692135 @default.
• W2890639359 creator A5072962459 @default.
• W2890639359 creator A5077607499 @default.
• W2890639359 date "2018-09-06" @default.
• W2890639359 modified "2023-10-17" @default.
• W2890639359 title "Early life stress leads to sex differences in development of depressive-like outcomes in a mouse model" @default.
• W2890639359 cites W1631193623 @default.
• W2890639359 cites W177461786 @default.
• W2890639359 cites W1965649599 @default.
• W2890639359 cites W1968143490 @default.
• W2890639359 cites W1974719089 @default.
• W2890639359 cites W1977828853 @default.
• W2890639359 cites W1979040868 @default.
• W2890639359 cites W1980790168 @default.
• W2890639359 cites W1981097208 @default.
• W2890639359 cites W1981459575 @default.
• W2890639359 cites W1982925999 @default.
• W2890639359 cites W1986896720 @default.
• W2890639359 cites W1988125482 @default.
• W2890639359 cites W1994681453 @default.
• W2890639359 cites W1994797683 @default.
• W2890639359 cites W1996092905 @default.
• W2890639359 cites W2000206356 @default.
• W2890639359 cites W2000209446 @default.
• W2890639359 cites W2003159048 @default.
• W2890639359 cites W2015760106 @default.
• W2890639359 cites W2017667457 @default.
• W2890639359 cites W2017930909 @default.
• W2890639359 cites W2023081218 @default.
• W2890639359 cites W2023288605 @default.
• W2890639359 cites W2026460327 @default.
• W2890639359 cites W2030260413 @default.
• W2890639359 cites W2034772421 @default.
• W2890639359 cites W2050042714 @default.
• W2890639359 cites W2056280621 @default.
• W2890639359 cites W2059134061 @default.
• W2890639359 cites W2060159413 @default.
• W2890639359 cites W2067672386 @default.
• W2890639359 cites W2068999504 @default.
• W2890639359 cites W2070638317 @default.
• W2890639359 cites W2079714688 @default.
• W2890639359 cites W2080695850 @default.
• W2890639359 cites W2085425339 @default.
• W2890639359 cites W2086936738 @default.
• W2890639359 cites W2090724033 @default.
• W2890639359 cites W2091064555 @default.
• W2890639359 cites W2099129729 @default.
• W2890639359 cites W2100086239 @default.
• W2890639359 cites W2111407003 @default.
• W2890639359 cites W2116839388 @default.
• W2890639359 cites W2124203952 @default.
• W2890639359 cites W2135422013 @default.
• W2890639359 cites W2138757170 @default.
• W2890639359 cites W2148619783 @default.
• W2890639359 cites W2150355913 @default.
• W2890639359 cites W2154515843 @default.
• W2890639359 cites W2155785248 @default.
• W2890639359 cites W2160223635 @default.
• W2890639359 cites W2162016125 @default.
• W2890639359 cites W2162248866 @default.
• W2890639359 cites W2163075911 @default.
• W2890639359 cites W2164689073 @default.
• W2890639359 cites W2166372248 @default.
• W2890639359 cites W2169358550 @default.
• W2890639359 cites W2197078876 @default.
• W2890639359 cites W2231821799 @default.
• W2890639359 cites W2345576129 @default.
• W2890639359 cites W2366754015 @default.
• W2890639359 cites W2410587014 @default.
• W2890639359 cites W2470457839 @default.
• W2890639359 cites W2515820045 @default.
• W2890639359 cites W2592073850 @default.
• W2890639359 cites W2609191686 @default.
• W2890639359 cites W2625629260 @default.
• W2890639359 cites W2751930669 @default.
• W2890639359 cites W2756006921 @default.
• W2890639359 cites W2768657049 @default.
• W2890639359 cites W2781659239 @default.
• W2890639359 cites W4253214908 @default.
• W2890639359 cites W978592036 @default.
• W2890639359 doi "https://doi.org/10.1038/s41386-018-0195-5" @default.
• W2890639359 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6372611" @default.
• W2890639359 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30188513" @default.
• W2890639359 hasPublicationYear "2018" @default.
• W2890639359 type Work @default.
• W2890639359 sameAs 2890639359 @default.
• W2890639359 citedByCount "138" @default.
• W2890639359 countsByYear W28906393592018 @default.
• W2890639359 countsByYear W28906393592019 @default.
• W2890639359 countsByYear W28906393592020 @default.
• W2890639359 countsByYear W28906393592021 @default.
• W2890639359 countsByYear W28906393592022 @default.

• next