FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890639595> ?p ?o ?g. }

• W2890639595 abstract "Leachables from dental restoratives induce toxicity in gingival and pulp tissues and affect tissue regeneration/healing. Appropriate testing of these materials requires a platform that mimics the in vivo environment and allows the architectural self-assembly of cells into tissue constructs. In this study, we employ a new 3D model to assess the impact of triethyleneglycol dimethacrylate (TEGDMA) on early organization and advanced recruitment/accumulation of immortalized mouse gingival fibroblasts (GFs) and dental papilla mesenchymal cells (DPMCs) in extracellular matrix. We hypothesize that TEGDMA (1) interferes with the developmental architecture of GFs and DPMCs, and (2) inhibits the deposition of mineral. To test these hypotheses, GFs and DPMCs were incubated with the soluble TEGDMA at concentrations (0-2.5) mmol/L. Diameter and thickness of the constructs were determined by microscopic analysis. Cell differentiation was assessed by immunocytochemistry and the secreted mineral detected by alizarin-red staining. TEGDMA interfered with the development of GFs and/or DPMCs microtissues in a dose-dependent manner by inhibiting growth of inter-spherical cell layers and decreasing spheroid size (four to six times). At low/moderate TEGDMA levels, GFs organoids retained their structures while reducing thickness up to 21%. In contrast, at low TEGDMA doses, architecture of DPMC organoids was altered and thickness decreased almost twofold. Overall, developmental ability of TEGDMA-exposed GFs and DPMCs depended on TEGDMA level. GFs constructs were more resistant to structural modifications. The employed 3D platform was proven as an efficient tool for quantifying the effects of leachables on tissue repair capacities of gingiva and dental pulp." @default.
• W2890639595 created "2018-09-27" @default.
• W2890639595 creator A5000746156 @default.
• W2890639595 creator A5062016727 @default.
• W2890639595 creator A5069757094 @default.
• W2890639595 creator A5081598268 @default.
• W2890639595 date "2018-09-19" @default.
• W2890639595 modified "2023-09-27" @default.
• W2890639595 title "Assessing the effect of triethyleneglycol dimethacrylate on tissue repair in 3D organotypic cultures" @default.
• W2890639595 cites W101063900 @default.
• W2890639595 cites W1693876897 @default.
• W2890639595 cites W1928222724 @default.
• W2890639595 cites W1963817763 @default.
• W2890639595 cites W1972528079 @default.
• W2890639595 cites W1972924335 @default.
• W2890639595 cites W1974603116 @default.
• W2890639595 cites W1983905976 @default.
• W2890639595 cites W1986008777 @default.
• W2890639595 cites W1996682782 @default.
• W2890639595 cites W2004668392 @default.
• W2890639595 cites W2005035019 @default.
• W2890639595 cites W2005431883 @default.
• W2890639595 cites W2008484769 @default.
• W2890639595 cites W2008757142 @default.
• W2890639595 cites W2012777147 @default.
• W2890639595 cites W2017259440 @default.
• W2890639595 cites W2017391462 @default.
• W2890639595 cites W2020337410 @default.
• W2890639595 cites W2021550972 @default.
• W2890639595 cites W2024126711 @default.
• W2890639595 cites W2024229755 @default.
• W2890639595 cites W2027012204 @default.
• W2890639595 cites W2027654288 @default.
• W2890639595 cites W2027980484 @default.
• W2890639595 cites W2030581306 @default.
• W2890639595 cites W2030916896 @default.
• W2890639595 cites W2030972105 @default.
• W2890639595 cites W2035644094 @default.
• W2890639595 cites W2037322299 @default.
• W2890639595 cites W2039062253 @default.
• W2890639595 cites W2040810212 @default.
• W2890639595 cites W2044118923 @default.
• W2890639595 cites W2048633493 @default.
• W2890639595 cites W2049622909 @default.
• W2890639595 cites W2050208472 @default.
• W2890639595 cites W2051879202 @default.
• W2890639595 cites W2058252405 @default.
• W2890639595 cites W2060498128 @default.
• W2890639595 cites W2060637658 @default.
• W2890639595 cites W2062317955 @default.
• W2890639595 cites W2062523201 @default.
• W2890639595 cites W2065201010 @default.
• W2890639595 cites W2066440651 @default.
• W2890639595 cites W2068808589 @default.
• W2890639595 cites W2075889966 @default.
• W2890639595 cites W2078664939 @default.
• W2890639595 cites W2090191301 @default.
• W2890639595 cites W2090220251 @default.
• W2890639595 cites W2090304199 @default.
• W2890639595 cites W2096827433 @default.
• W2890639595 cites W2100687920 @default.
• W2890639595 cites W2104466751 @default.
• W2890639595 cites W2108933664 @default.
• W2890639595 cites W2111010707 @default.
• W2890639595 cites W2113069885 @default.
• W2890639595 cites W2114222300 @default.
• W2890639595 cites W2115505121 @default.
• W2890639595 cites W2130002748 @default.
• W2890639595 cites W2130516299 @default.
• W2890639595 cites W2130851152 @default.
• W2890639595 cites W2136787198 @default.
• W2890639595 cites W2138338605 @default.
• W2890639595 cites W2141884737 @default.
• W2890639595 cites W2143113229 @default.
• W2890639595 cites W2145040826 @default.
• W2890639595 cites W2152773911 @default.
• W2890639595 cites W2155213151 @default.
• W2890639595 cites W2156862776 @default.
• W2890639595 cites W2160569622 @default.
• W2890639595 cites W2167540239 @default.
• W2890639595 cites W2331628193 @default.
• W2890639595 cites W2341124923 @default.
• W2890639595 cites W2443093978 @default.
• W2890639595 cites W2469826780 @default.
• W2890639595 cites W2517979475 @default.
• W2890639595 cites W2519614541 @default.
• W2890639595 cites W2521366123 @default.
• W2890639595 cites W2522388301 @default.
• W2890639595 cites W2606008614 @default.
• W2890639595 cites W2769068713 @default.
• W2890639595 cites W2774242727 @default.
• W2890639595 doi "https://doi.org/10.1002/jat.3714" @default.
• W2890639595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30229966" @default.
• W2890639595 hasPublicationYear "2018" @default.
• W2890639595 type Work @default.
• W2890639595 sameAs 2890639595 @default.
• W2890639595 citedByCount "6" @default.
• W2890639595 countsByYear W28906395952019 @default.
• W2890639595 countsByYear W28906395952020 @default.
• W2890639595 crossrefType "journal-article" @default.

• next