Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890641392> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2890641392 abstract "5050 Background: The enzyme encoded by the HSD3B1(1245C) variant allele has been shown to promote castration-resistant prostate cancer by increasing intratumoral dihydrotestosterone synthesis. In the setting of biochemical recurrence (BCR) following prostatectomy, inheritance of the variant allele has been associated with inferior clinical outcomes for men treated with androgen deprivation therapy (ADT). Whether the same is true in the context of BCR after radiotherapy (RT) is unknown. Methods: We determined HSD3B1 genotype retrospectively in men treated with ADT for post-RT BCR using an established biorepository at a large academic center. We analyzed time-to-progression (TTP), time-to-metastasis (TTM), and overall survival (OS) according to HSD3B1genotype using an additive genetic model with the log-rank trend test. Multivariable analyses (MVA) were performed to adjust for known prognostic factors with Cox regression. Results: We identified 218 men treated with ADT for BCR after RT, of whom 213 (98%) were successfully genotyped (46%, 45% and 9% carrying 0, 1, and 2 variant alleles, respectively). Median follow-up was 7.9 years (yrs). Demographic and treatment factors were similar across genotypes. Median TTP was 2.3 (95% CI: 1.6, 3.1) yrs in men who inherited 0 variant alleles, 2.3 (1.5, 3.3) yrs with 1 variant allele, and 1.4 (0.7, 3.3) yrs with 2 variant alleles (P = 0.683). Median TTM diminished with the number of variant alleles inherited (7.4 [6.7, 9.7], 5.8 [4.9, 6.5] and 4.4 [3.0, 5.7] yrs, respectively (P = 0.030). No difference in OS was detected (P = 0.305). On MVA with 0 variant alleles as the reference, the adjusted hazard ratio (HR) for metastasis was (1.19 [0.74, 1.92]; P = 0.480) for 1 allele and (2.01 [1.02, 3.97]; P = 0.045) for 2 alleles. MVA did not demonstrate significant differences in TTP or OS. Conclusions: The HSD3B1(1245C) allele that enhances dihydrotestosterone synthesis is associated with time-to-metastasis in men treated with ADT for BCR after RT for prostate cancer. Notably, 49% of men had received prior ADT as part of local therapy and 56% received an anti-androgen during ADT for BCR, which may blunt the effect of the variant allele." @default.
- W2890641392 created "2018-09-27" @default.
- W2890641392 creator A5015974298 @default.
- W2890641392 creator A5037987036 @default.
- W2890641392 creator A5045254828 @default.
- W2890641392 creator A5048151721 @default.
- W2890641392 creator A5054519252 @default.
- W2890641392 creator A5056766924 @default.
- W2890641392 creator A5066816851 @default.
- W2890641392 creator A5078212843 @default.
- W2890641392 date "2017-05-20" @default.
- W2890641392 modified "2023-09-26" @default.
- W2890641392 title "HSD3B1 genotype and response to androgen deprivation therapy for biochemical recurrence after radiotherapy for localized prostate cancer." @default.
- W2890641392 doi "https://doi.org/10.1200/jco.2017.35.15_suppl.5050" @default.
- W2890641392 hasPublicationYear "2017" @default.
- W2890641392 type Work @default.
- W2890641392 sameAs 2890641392 @default.
- W2890641392 citedByCount "1" @default.
- W2890641392 countsByYear W28906413922018 @default.
- W2890641392 crossrefType "journal-article" @default.
- W2890641392 hasAuthorship W2890641392A5015974298 @default.
- W2890641392 hasAuthorship W2890641392A5037987036 @default.
- W2890641392 hasAuthorship W2890641392A5045254828 @default.
- W2890641392 hasAuthorship W2890641392A5048151721 @default.
- W2890641392 hasAuthorship W2890641392A5054519252 @default.
- W2890641392 hasAuthorship W2890641392A5056766924 @default.
- W2890641392 hasAuthorship W2890641392A5066816851 @default.
- W2890641392 hasAuthorship W2890641392A5078212843 @default.
- W2890641392 hasConcept C104317684 @default.
- W2890641392 hasConcept C121608353 @default.
- W2890641392 hasConcept C126322002 @default.
- W2890641392 hasConcept C135763542 @default.
- W2890641392 hasConcept C143998085 @default.
- W2890641392 hasConcept C2776235491 @default.
- W2890641392 hasConcept C2777008409 @default.
- W2890641392 hasConcept C2777899217 @default.
- W2890641392 hasConcept C2777911890 @default.
- W2890641392 hasConcept C2779466945 @default.
- W2890641392 hasConcept C2780192828 @default.
- W2890641392 hasConcept C502942594 @default.
- W2890641392 hasConcept C509974204 @default.
- W2890641392 hasConcept C54355233 @default.
- W2890641392 hasConcept C71315377 @default.
- W2890641392 hasConcept C71924100 @default.
- W2890641392 hasConcept C86803240 @default.
- W2890641392 hasConceptScore W2890641392C104317684 @default.
- W2890641392 hasConceptScore W2890641392C121608353 @default.
- W2890641392 hasConceptScore W2890641392C126322002 @default.
- W2890641392 hasConceptScore W2890641392C135763542 @default.
- W2890641392 hasConceptScore W2890641392C143998085 @default.
- W2890641392 hasConceptScore W2890641392C2776235491 @default.
- W2890641392 hasConceptScore W2890641392C2777008409 @default.
- W2890641392 hasConceptScore W2890641392C2777899217 @default.
- W2890641392 hasConceptScore W2890641392C2777911890 @default.
- W2890641392 hasConceptScore W2890641392C2779466945 @default.
- W2890641392 hasConceptScore W2890641392C2780192828 @default.
- W2890641392 hasConceptScore W2890641392C502942594 @default.
- W2890641392 hasConceptScore W2890641392C509974204 @default.
- W2890641392 hasConceptScore W2890641392C54355233 @default.
- W2890641392 hasConceptScore W2890641392C71315377 @default.
- W2890641392 hasConceptScore W2890641392C71924100 @default.
- W2890641392 hasConceptScore W2890641392C86803240 @default.
- W2890641392 hasLocation W28906413921 @default.
- W2890641392 hasOpenAccess W2890641392 @default.
- W2890641392 hasPrimaryLocation W28906413921 @default.
- W2890641392 hasRelatedWork W2011714693 @default.
- W2890641392 hasRelatedWork W2053369974 @default.
- W2890641392 hasRelatedWork W2071417433 @default.
- W2890641392 hasRelatedWork W2099477169 @default.
- W2890641392 hasRelatedWork W2137996608 @default.
- W2890641392 hasRelatedWork W2141569270 @default.
- W2890641392 hasRelatedWork W2320707254 @default.
- W2890641392 hasRelatedWork W2528225096 @default.
- W2890641392 hasRelatedWork W2591511917 @default.
- W2890641392 hasRelatedWork W2794972561 @default.
- W2890641392 hasRelatedWork W2803860364 @default.
- W2890641392 hasRelatedWork W2891052997 @default.
- W2890641392 hasRelatedWork W2891864841 @default.
- W2890641392 hasRelatedWork W2946852833 @default.
- W2890641392 hasRelatedWork W2969491553 @default.
- W2890641392 hasRelatedWork W3081529667 @default.
- W2890641392 hasRelatedWork W3087799167 @default.
- W2890641392 hasRelatedWork W3095147403 @default.
- W2890641392 hasRelatedWork W3183963664 @default.
- W2890641392 hasRelatedWork W3204287984 @default.
- W2890641392 isParatext "false" @default.
- W2890641392 isRetracted "false" @default.
- W2890641392 magId "2890641392" @default.
- W2890641392 workType "article" @default.