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- W2890644813 endingPage "1020" @default.
- W2890644813 startingPage "1005" @default.
- W2890644813 abstract "High‐mobility group box‐1 (HMGB1) is a ubiquitous protein. While initially thought to be simply an architectural protein due to its DNA‐binding ability, evidence from the last decade suggests that HMGB1 is a key protein participating in the pathogenesis of acute liver injury and chronic liver disease. When it is passively released or actively secreted after injury, HMGB1 acts as a damage‐associated molecular pattern that communicates injury and inflammation to neighboring cells by the receptor for advanced glycation end products or toll‐like receptor 4, among others. In the setting of acute liver injury, HMGB1 participates in ischemia/reperfusion, sepsis, and drug‐induced liver injury. In the context of chronic liver disease, it has been implicated in alcoholic liver disease, liver fibrosis, nonalcoholic steatohepatitis, and hepatocellular carcinoma. Recently, specific posttranslational modifications have been identified that could condition the effects of the protein in the liver. Here, we provide a detailed review of how HMGB1 signaling participates in acute liver injury and chronic liver disease." @default.
- W2890644813 created "2018-09-27" @default.
- W2890644813 creator A5025093652 @default.
- W2890644813 creator A5055941563 @default.
- W2890644813 creator A5068663709 @default.
- W2890644813 date "2018-09-01" @default.
- W2890644813 modified "2023-10-14" @default.
- W2890644813 title "High‐Mobility Group Box‐1 and Liver Disease" @default.
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