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• W2890644970 abstract "Nanocrystallization and amorphization have proven to be two effective strategies to improve the bioavailability of water-insoluble drugs. The purpose of our work was to develop a nano-formulated tablet of sirolimus (SRL) for enhanced dissolution. Amorphous SRL nanocomposites were prepared using anti-solvent precipitation via a high-gravity rotating packed bed. Various factors that affect particle size and size distribution, such as excipients, rotating speed, antisolvent/solvent flow rate, were investigated. Structure, stability and in vitro dissolution of the as-prepared SRL were evaluated. Furthermore, the nanoparticulated SRL tablet formula was screened to control drug release. Importantly, SRL tablets exhibit different dissolution profile by adjusting HPMC (hydroxypropyl methyl cellulose) content, which makes them more suitable for various formulation developments." @default.
• W2890644970 created "2018-09-27" @default.
• W2890644970 creator A5022202296 @default.
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• W2890644970 date "2018-09-11" @default.
• W2890644970 modified "2023-10-05" @default.
• W2890644970 title "Amorphous Nanoparticulate Formulation of Sirolimus and Its Tablets" @default.
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• W2890644970 doi "https://doi.org/10.3390/pharmaceutics10030155" @default.
• W2890644970 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6161202" @default.
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• W2890644970 hasPublicationYear "2018" @default.
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