FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890660869> ?p ?o ?g. }

• W2890660869 endingPage "13" @default.
• W2890660869 startingPage "1" @default.
• W2890660869 abstract "Inhibition of tumor cell migration is a treatment strategy for patients with colorectal cancer (CRC). SCF-dependent activation of c-KIT is responsible for migration of c-KIT positive [c-KIT(+)] cells of CRC. Drug resistance to Imatinib Mesylate (c-KIT inhibitor) has emerged. Inhibition of mTOR can induce autophagic degradation of c-KIT. (+)-usnic acid [(+)-UA], isolated from lichens, has two major functions including induction of proton shuttle and targeting inhibition of mTOR. To reduce hepatotoxicity, the treatment concentration of (+)-UA should be lower than 10 μ M. HCT116 cells and LS174 cells were employed to investigate the inhibiting effect of (+)-UA (<10 μ M) on SCF-mediated migration of c-KIT(+) CRC cells. HCT116 cells were employed to investigate the molecular mechanisms. The results indicated that firstly, 8 μ M (+)-UA decreased ATP content via uncoupling; secondly, 8 μ M (+)-UA induced mTOR inhibition, thereby mediated activation suppression of PKC-A, and induced the autophagy of the completed autophagic flux that resulted in the autophagic degradation and transcriptional inhibition of c-KIT and the increase in LDH release; ultimately, 8 μ M (+)-UA inhibited SCF-mediated migration of CRC c-KIT(+) cells. Taken together, 8 μ M could be determined as the effective concentration for (+)-UA to inhibit SCF-mediated migration of CRC c-KIT(+) cells." @default.
• W2890660869 created "2018-09-27" @default.
• W2890660869 creator A5018031284 @default.
• W2890660869 creator A5029812230 @default.
• W2890660869 creator A5037677450 @default.
• W2890660869 creator A5039005708 @default.
• W2890660869 creator A5039664887 @default.
• W2890660869 creator A5040013025 @default.
• W2890660869 creator A5041334569 @default.
• W2890660869 creator A5044888290 @default.
• W2890660869 creator A5048307356 @default.
• W2890660869 creator A5049225160 @default.
• W2890660869 creator A5049533681 @default.
• W2890660869 creator A5052918741 @default.
• W2890660869 creator A5053301498 @default.
• W2890660869 date "2018-09-12" @default.
• W2890660869 modified "2023-10-16" @default.
• W2890660869 title "(+)-Usnic Acid Inhibits Migration of c-KIT Positive Cells in Human Colorectal Cancer" @default.
• W2890660869 cites W1732266052 @default.
• W2890660869 cites W1801596893 @default.
• W2890660869 cites W1824234743 @default.
• W2890660869 cites W1884631150 @default.
• W2890660869 cites W1964187293 @default.
• W2890660869 cites W1976156376 @default.
• W2890660869 cites W1976972237 @default.
• W2890660869 cites W1988212011 @default.
• W2890660869 cites W1991836743 @default.
• W2890660869 cites W1996983679 @default.
• W2890660869 cites W2001632031 @default.
• W2890660869 cites W2010186217 @default.
• W2890660869 cites W2019889178 @default.
• W2890660869 cites W2038058793 @default.
• W2890660869 cites W2040509262 @default.
• W2890660869 cites W2041822723 @default.
• W2890660869 cites W2056350697 @default.
• W2890660869 cites W2076947916 @default.
• W2890660869 cites W2080726329 @default.
• W2890660869 cites W2085538067 @default.
• W2890660869 cites W2089547132 @default.
• W2890660869 cites W2103074028 @default.
• W2890660869 cites W2115074159 @default.
• W2890660869 cites W2127401379 @default.
• W2890660869 cites W2140473883 @default.
• W2890660869 cites W2154231250 @default.
• W2890660869 cites W2161654775 @default.
• W2890660869 cites W2168420558 @default.
• W2890660869 cites W2191245558 @default.
• W2890660869 cites W2266910759 @default.
• W2890660869 cites W2325794785 @default.
• W2890660869 cites W2395403662 @default.
• W2890660869 cites W2569057758 @default.
• W2890660869 cites W2569451019 @default.
• W2890660869 cites W2592591707 @default.
• W2890660869 cites W2594865385 @default.
• W2890660869 cites W2793900392 @default.
• W2890660869 cites W391925564 @default.
• W2890660869 doi "https://doi.org/10.1155/2018/5149436" @default.
• W2890660869 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6157178" @default.
• W2890660869 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30298093" @default.
• W2890660869 hasPublicationYear "2018" @default.
• W2890660869 type Work @default.
• W2890660869 sameAs 2890660869 @default.
• W2890660869 citedByCount "8" @default.
• W2890660869 countsByYear W28906608692019 @default.
• W2890660869 countsByYear W28906608692020 @default.
• W2890660869 countsByYear W28906608692021 @default.
• W2890660869 countsByYear W28906608692022 @default.
• W2890660869 countsByYear W28906608692023 @default.
• W2890660869 crossrefType "journal-article" @default.
• W2890660869 hasAuthorship W2890660869A5018031284 @default.
• W2890660869 hasAuthorship W2890660869A5029812230 @default.
• W2890660869 hasAuthorship W2890660869A5037677450 @default.
• W2890660869 hasAuthorship W2890660869A5039005708 @default.
• W2890660869 hasAuthorship W2890660869A5039664887 @default.
• W2890660869 hasAuthorship W2890660869A5040013025 @default.
• W2890660869 hasAuthorship W2890660869A5041334569 @default.
• W2890660869 hasAuthorship W2890660869A5044888290 @default.
• W2890660869 hasAuthorship W2890660869A5048307356 @default.
• W2890660869 hasAuthorship W2890660869A5049225160 @default.
• W2890660869 hasAuthorship W2890660869A5049533681 @default.
• W2890660869 hasAuthorship W2890660869A5052918741 @default.
• W2890660869 hasAuthorship W2890660869A5053301498 @default.
• W2890660869 hasBestOaLocation W28906608691 @default.
• W2890660869 hasConcept C120149898 @default.
• W2890660869 hasConcept C121608353 @default.
• W2890660869 hasConcept C126322002 @default.
• W2890660869 hasConcept C137738243 @default.
• W2890660869 hasConcept C1491633281 @default.
• W2890660869 hasConcept C185592680 @default.
• W2890660869 hasConcept C190283241 @default.
• W2890660869 hasConcept C203522944 @default.
• W2890660869 hasConcept C2777583451 @default.
• W2890660869 hasConcept C2778200459 @default.
• W2890660869 hasConcept C2778729363 @default.
• W2890660869 hasConcept C2779707156 @default.
• W2890660869 hasConcept C502942594 @default.
• W2890660869 hasConcept C526805850 @default.
• W2890660869 hasConcept C55493867 @default.

• next