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• W2890665033 abstract "A feature of bacterial chromosomes is that highly expressed essential genes are usually located close to the origin of replication. Because bacteria have overlapping cycles of replication, genes located close to the origin will often be present in multiple copies, and this is thought to be of selective benefit where high levels of expression support high growth rate. However, the magnitude of this selective effect and whether other forces could be at play are poorly understood. To study this, we translocated a highly expressed essential operon, tufB , to different locations and measured growth fitness. We found that transcriptional regulation buffered the effects of translocation and that even under conditions where growth rate was reduced, genetic changes that increased the expression of tufB were easily and rapidly selected. We conclude, at least for tufB , that forces other than gene dosage may be significant in selecting for chromosomal location." @default.
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• W2890665033 date "2018-11-07" @default.
• W2890665033 modified "2023-09-28" @default.
• W2890665033 title "Transcriptional Regulation Buffers Gene Dosage Effects on a Highly Expressed Operon in Salmonella" @default.
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• W2890665033 doi "https://doi.org/10.1128/mbio.01446-18" @default.
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