Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890675463> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2890675463 abstract "Current literature reports that half of critically ill patients are continued on broad-spectrum antibiotics beyond 72 hours despite no confirmed infection. The purpose of this retrospective study was to identify the incidence of and risk factors for prolonged empiric antimicrobial therapy (PEAT) in adult neurocritical care (NCC) patients treated for pneumonia, hypothesizing that NCC patients will have a higher incidence of PEAT.This is a retrospective chart review of adult NCC patients treated for pneumonia. Antibiotic therapy was classified as restrictive, definitive, or PEAT based on culture results and timing of discontinuation or de-escalation.A total of 95 patients (median age: 57 years; 28.4% female; admission diagnosis: 73.7% cerebrovascular, 10.5% neuromuscular, and 15.8% seizure-related) were included in this study. Overall, 59% of antibiotic regimens were considered PEAT, with vancomycin and piperacillin/tazobactam being most commonly prescribed. Median duration of therapy was 6.8 days, with shorter duration in patients with negative culture results compared to those with positive culture results (6.1 days [interquartile range, IQR 4.0-8.3] vs 7.2 days [IQR 5.8-10.3], P < .05). On multivariable analysis, elevated baseline white blood cell count, meeting Centers for Disease Control criteria for pneumonia, and negative bacterial culture were significantly associated with PEAT.The incidence of prolonged empiric antibiotic use was high in the NCC population. Patients are at particular risk for PEAT if they have negative cultures. All but one patient did not meet criteria for central fever, highlighting the challenges in identifying fever etiology in the NCC population." @default.
- W2890675463 created "2018-09-27" @default.
- W2890675463 creator A5018761227 @default.
- W2890675463 creator A5063400439 @default.
- W2890675463 creator A5076370287 @default.
- W2890675463 creator A5088985716 @default.
- W2890675463 date "2018-09-09" @default.
- W2890675463 modified "2023-09-25" @default.
- W2890675463 title "A Retrospective Analysis of Prolonged Empiric Antibiotic Therapy for Pneumonia Among Adult Neurocritical Care Patients" @default.
- W2890675463 cites W1972370337 @default.
- W2890675463 cites W2003756489 @default.
- W2890675463 cites W2084434593 @default.
- W2890675463 cites W2139937737 @default.
- W2890675463 cites W2152848738 @default.
- W2890675463 cites W2318492449 @default.
- W2890675463 cites W2473016454 @default.
- W2890675463 cites W2565094370 @default.
- W2890675463 cites W2652297891 @default.
- W2890675463 cites W2786940348 @default.
- W2890675463 cites W4211194064 @default.
- W2890675463 cites W4292805086 @default.
- W2890675463 doi "https://doi.org/10.1177/1941874418792138" @default.
- W2890675463 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6327239" @default.
- W2890675463 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30671159" @default.
- W2890675463 hasPublicationYear "2018" @default.
- W2890675463 type Work @default.
- W2890675463 sameAs 2890675463 @default.
- W2890675463 citedByCount "2" @default.
- W2890675463 countsByYear W28906754632021 @default.
- W2890675463 countsByYear W28906754632022 @default.
- W2890675463 crossrefType "journal-article" @default.
- W2890675463 hasAuthorship W2890675463A5018761227 @default.
- W2890675463 hasAuthorship W2890675463A5063400439 @default.
- W2890675463 hasAuthorship W2890675463A5076370287 @default.
- W2890675463 hasAuthorship W2890675463A5088985716 @default.
- W2890675463 hasBestOaLocation W28906754631 @default.
- W2890675463 hasConcept C119060515 @default.
- W2890675463 hasConcept C120665830 @default.
- W2890675463 hasConcept C121332964 @default.
- W2890675463 hasConcept C126322002 @default.
- W2890675463 hasConcept C165455791 @default.
- W2890675463 hasConcept C167135981 @default.
- W2890675463 hasConcept C177713679 @default.
- W2890675463 hasConcept C2777914695 @default.
- W2890675463 hasConcept C2778715236 @default.
- W2890675463 hasConcept C2908647359 @default.
- W2890675463 hasConcept C61511704 @default.
- W2890675463 hasConcept C71924100 @default.
- W2890675463 hasConcept C99454951 @default.
- W2890675463 hasConceptScore W2890675463C119060515 @default.
- W2890675463 hasConceptScore W2890675463C120665830 @default.
- W2890675463 hasConceptScore W2890675463C121332964 @default.
- W2890675463 hasConceptScore W2890675463C126322002 @default.
- W2890675463 hasConceptScore W2890675463C165455791 @default.
- W2890675463 hasConceptScore W2890675463C167135981 @default.
- W2890675463 hasConceptScore W2890675463C177713679 @default.
- W2890675463 hasConceptScore W2890675463C2777914695 @default.
- W2890675463 hasConceptScore W2890675463C2778715236 @default.
- W2890675463 hasConceptScore W2890675463C2908647359 @default.
- W2890675463 hasConceptScore W2890675463C61511704 @default.
- W2890675463 hasConceptScore W2890675463C71924100 @default.
- W2890675463 hasConceptScore W2890675463C99454951 @default.
- W2890675463 hasLocation W28906754631 @default.
- W2890675463 hasLocation W28906754632 @default.
- W2890675463 hasLocation W28906754633 @default.
- W2890675463 hasLocation W28906754634 @default.
- W2890675463 hasOpenAccess W2890675463 @default.
- W2890675463 hasPrimaryLocation W28906754631 @default.
- W2890675463 hasRelatedWork W2004679513 @default.
- W2890675463 hasRelatedWork W202397887 @default.
- W2890675463 hasRelatedWork W2088291874 @default.
- W2890675463 hasRelatedWork W2093285338 @default.
- W2890675463 hasRelatedWork W2412558605 @default.
- W2890675463 hasRelatedWork W2414062972 @default.
- W2890675463 hasRelatedWork W2564079701 @default.
- W2890675463 hasRelatedWork W2890675463 @default.
- W2890675463 hasRelatedWork W4240455838 @default.
- W2890675463 hasRelatedWork W2396790870 @default.
- W2890675463 isParatext "false" @default.
- W2890675463 isRetracted "false" @default.
- W2890675463 magId "2890675463" @default.
- W2890675463 workType "article" @default.