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• W2890690689 abstract "Computational models have become essential in predicting medical device efficacy prior to clinical studies. To investigate the performance of a left-ventricular assist device (LVAD), a fully-coupled cardiac fluid-electromechanics finite element model was developed, incorporating electrical activation, passive and active myocardial mechanics, as well as blood hemodynamics solved simultaneously in an idealized biventricular geometry. Electrical activation was initiated using a simplified Purkinje network with one-way coupling to the surrounding myocardium. Phenomenological action potential and excitation-contraction equations were adapted to trigger myocardial contraction. Action potential propagation was formulated within a material frame to emulate gap junction-controlled propagation, such that the activation sequence was independent of myocardial deformation. Passive cardiac mechanics were governed by a transverse isotropic hyperelastic constitutive formulation. Blood velocity and pressure were determined by the incompressible Navier-Stokes formulations with a closed-loop Windkessel circuit governing the circulatory load. To investigate heart-LVAD interaction, we reduced the left ventricular (LV) contraction stress to mimic a failing heart, and inserted a LVAD cannula at the LV apex with continuous flow governing the outflow rate. A proportional controller was implemented to determine the pump motor voltage whilst maintaining pump motor speed. Following LVAD insertion, the model revealed a change in the LV pressure-volume loop shape from rectangular to triangular. At higher pump speeds, aortic ejection ceased and the LV decompressed to smaller end diastolic volumes. After multiple cycles, the LV cavity gradually collapsed along with a drop in pump motor current. The model was therefore able to predict ventricular collapse, indicating its utility for future development of control algorithms and pre-clinical testing of LVADs to avoid LV collapse in recipients." @default.
• W2890690689 created "2018-09-27" @default.
• W2890690689 creator A5014720715 @default.
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• W2890690689 date "2018-09-11" @default.
• W2890690689 modified "2023-10-12" @default.
• W2890690689 title "A Multiphysics Biventricular Cardiac Model: Simulations With a Left-Ventricular Assist Device" @default.
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• W2890690689 doi "https://doi.org/10.3389/fphys.2018.01259" @default.
• W2890690689 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6142745" @default.
• W2890690689 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30271353" @default.
• W2890690689 hasPublicationYear "2018" @default.
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