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• W2890696102 abstract "Several evidences emphasize B-cell pathogenic roles in multiple sclerosis (MS). We performed transcriptome analyses on peripheral B cells from therapy-free patients and age/sex-matched controls. Down-regulation of two transcripts (interferon response factor 1–IRF1, and C-X-C motif chemokine 10–CXCL10), belonging to the same pathway, was validated by RT-PCR in 26 patients and 21 controls. IRF1 and CXCL10 transcripts share potential seeding sequences for hsa-miR-424, that resulted up-regulated in MS patients. We confirmed this interaction and its functional effect by transfection experiments. Consistent findings indicate down-regulation of IRF1/CXCL10 axis, that may plausibly contribute to a pro-survival status of B cells in MS." @default.
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• W2890696102 date "2018-11-01" @default.
• W2890696102 modified "2023-10-18" @default.
• W2890696102 title "Analysis of coding and non-coding transcriptome of peripheral B cells reveals an altered interferon response factor (IRF)-1 pathway in multiple sclerosis patients" @default.
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• W2890696102 doi "https://doi.org/10.1016/j.jneuroim.2018.09.005" @default.
• W2890696102 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30270021" @default.
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