FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890697019> ?p ?o ?g. }

• W2890697019 abstract "Broadly neutralizing antibodies (bnAbs) against HIV-1 are an effective means of preventing transmission. To better understand the mechanisms by which HIV-specific bnAbs naturally develop, we investigated blood and lymphoid tissue in pediatric infection, since potent bnAbs develop with greater frequency in children than adults. As in adults, the frequency of circulating effector T-follicular helper cells (TFH) in HIV infected, treatment naïve children correlates with neutralization breadth. However, major differences between children and adults were also observed both in circulation, and in a small number of tonsil samples. In children, TFH cells are significantly more abundant, both in blood and in lymphoid tissue germinal centers, than in adults. Second, HIV-specific TFH cells are more frequent in pediatric than in adult lymphoid tissue and secrete the signature cytokine IL-21, which HIV-infected adults do not. Third, the enrichment of IL-21-secreting HIV-specific TFH in pediatric lymphoid tissue is accompanied by increased TFH regulation via more abundant regulatory follicular T-cells and HIV-specific CXCR5+ CD8 T-cells compared to adults. The relationship between regulation and neutralization breadth is also observed in the pediatric PBMC samples and correlates with neutralization breadth. Matching neutralization data from lymphoid tissue samples is not available. However, the distinction between infected children and adults in the magnitude, quality and regulation of HIV-specific TFH responses is consistent with the superior ability of children to develop high-frequency, potent bnAbs. These findings suggest the possibility that the optimal timing for next generation vaccine strategies designed to induce high-frequency, potent bnAbs to prevent HIV infection in adults would be in childhood." @default.
• W2890697019 created "2018-09-27" @default.
• W2890697019 creator A5008361747 @default.
• W2890697019 creator A5011089199 @default.
• W2890697019 creator A5011385630 @default.
• W2890697019 creator A5018523831 @default.
• W2890697019 creator A5030822254 @default.
• W2890697019 creator A5038341964 @default.
• W2890697019 creator A5040954811 @default.
• W2890697019 creator A5042037427 @default.
• W2890697019 creator A5043346206 @default.
• W2890697019 creator A5048941633 @default.
• W2890697019 creator A5062989379 @default.
• W2890697019 creator A5069840184 @default.
• W2890697019 creator A5073126768 @default.
• W2890697019 creator A5074085845 @default.
• W2890697019 creator A5075671793 @default.
• W2890697019 creator A5081409567 @default.
• W2890697019 creator A5082931934 @default.
• W2890697019 creator A5083743078 @default.
• W2890697019 creator A5089411837 @default.
• W2890697019 date "2018-09-12" @default.
• W2890697019 modified "2023-09-29" @default.
• W2890697019 title "High-Frequency, Functional HIV-Specific T-Follicular Helper and Regulatory Cells Are Present Within Germinal Centers in Children but Not Adults" @default.
• W2890697019 cites W146169322 @default.
• W2890697019 cites W1528520360 @default.
• W2890697019 cites W1594804329 @default.
• W2890697019 cites W1679691834 @default.
• W2890697019 cites W1785053820 @default.
• W2890697019 cites W1830463278 @default.
• W2890697019 cites W1901606394 @default.
• W2890697019 cites W1929236283 @default.
• W2890697019 cites W1964118640 @default.
• W2890697019 cites W1965031244 @default.
• W2890697019 cites W1972804526 @default.
• W2890697019 cites W1973486131 @default.
• W2890697019 cites W1978398372 @default.
• W2890697019 cites W1980685243 @default.
• W2890697019 cites W1981315958 @default.
• W2890697019 cites W1981732254 @default.
• W2890697019 cites W1992100179 @default.
• W2890697019 cites W1998403286 @default.
• W2890697019 cites W2001756645 @default.
• W2890697019 cites W2011340131 @default.
• W2890697019 cites W2014316583 @default.
• W2890697019 cites W2019576909 @default.
• W2890697019 cites W2024287923 @default.
• W2890697019 cites W2034668231 @default.
• W2890697019 cites W2037320559 @default.
• W2890697019 cites W2039033334 @default.
• W2890697019 cites W2042949083 @default.
• W2890697019 cites W2047426399 @default.
• W2890697019 cites W2052714671 @default.
• W2890697019 cites W2055923182 @default.
• W2890697019 cites W2060637301 @default.
• W2890697019 cites W2063195211 @default.
• W2890697019 cites W2063223775 @default.
• W2890697019 cites W2065329551 @default.
• W2890697019 cites W2071380288 @default.
• W2890697019 cites W2075175827 @default.
• W2890697019 cites W2077032728 @default.
• W2890697019 cites W2084310667 @default.
• W2890697019 cites W2085377023 @default.
• W2890697019 cites W2088543098 @default.
• W2890697019 cites W2093626188 @default.
• W2890697019 cites W2098013141 @default.
• W2890697019 cites W2108823547 @default.
• W2890697019 cites W2111038995 @default.
• W2890697019 cites W2126101979 @default.
• W2890697019 cites W2132773138 @default.
• W2890697019 cites W2134342374 @default.
• W2890697019 cites W2137446997 @default.
• W2890697019 cites W2137688247 @default.
• W2890697019 cites W2137939749 @default.
• W2890697019 cites W2139115754 @default.
• W2890697019 cites W2152048324 @default.
• W2890697019 cites W2152440860 @default.
• W2890697019 cites W2154522539 @default.
• W2890697019 cites W2162604485 @default.
• W2890697019 cites W2164147266 @default.
• W2890697019 cites W2164401365 @default.
• W2890697019 cites W2166862904 @default.
• W2890697019 cites W2167327834 @default.
• W2890697019 cites W2168949615 @default.
• W2890697019 cites W2171487621 @default.
• W2890697019 cites W2172074761 @default.
• W2890697019 cites W2235599671 @default.
• W2890697019 cites W2238536893 @default.
• W2890697019 cites W2486196806 @default.
• W2890697019 cites W2497442705 @default.
• W2890697019 cites W2500524648 @default.
• W2890697019 cites W2521133415 @default.
• W2890697019 cites W2527222363 @default.
• W2890697019 cites W2528284472 @default.
• W2890697019 cites W2556183938 @default.
• W2890697019 cites W2583015103 @default.
• W2890697019 cites W2583644004 @default.
• W2890697019 cites W2599501186 @default.
• W2890697019 cites W2759322113 @default.
• W2890697019 cites W2760965040 @default.

• next