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- W2890697585 endingPage "85" @default.
- W2890697585 startingPage "75" @default.
- W2890697585 abstract "Induction of interferons during viral infection is mediated by cellular proteins that recognise viral nucleic acids. MDA5 is one such sensor of virus presence and is activated by RNA. MDA5 is required for immunity against several classes of viruses, including picornaviruses. Recent work showed that mutations in the IFIH1 gene, encoding MDA5, lead to interferon-driven autoinflammatory diseases. Together with observations made in cancer cells, this suggests that MDA5 detects cellular RNAs in addition to viral RNAs. It is therefore important to understand the properties of the RNAs which activate MDA5. New data indicate that RNA length and secondary structure are features sensed by MDA5. We review these developments and discuss how MDA5 strikes a balance between antiviral immunity and autoinflammation." @default.
- W2890697585 created "2018-09-27" @default.
- W2890697585 creator A5044818017 @default.
- W2890697585 creator A5062707367 @default.
- W2890697585 creator A5078937992 @default.
- W2890697585 date "2019-01-01" @default.
- W2890697585 modified "2023-10-01" @default.
- W2890697585 title "A Balancing Act: MDA5 in Antiviral Immunity and Autoinflammation" @default.
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