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- W2890697983 endingPage "549" @default.
- W2890697983 startingPage "521" @default.
- W2890697983 abstract "Streptococcus pneumoniae (the pneumococcus) is a nasopharyngeal commensal and respiratory pathogen. Most isolates express a capsule, the species-wide diversity of which has been immunologically classified into ∼100 serotypes. Capsule polysaccharides have been combined into multivalent vaccines widely used in adults, but the T cell independence of the antibody response means they are not protective in infants. Polysaccharide conjugate vaccines (PCVs) trigger a T cell–dependent response through attaching a carrier protein to capsular polysaccharides. The immune response stimulated by PCVs in infants inhibits carriage of vaccine serotypes (VTs), resulting in population-wide herd immunity. These were replaced in carriage by non-VTs. Nevertheless, PCVs drove reductions in infant pneumococcal disease, due to the lower mean invasiveness of the postvaccination bacterial population; age-varying serotype invasiveness resulted in a smaller reduction in adult disease. Alternative vaccines being tested in trials are designed to provide species-wide protection through stimulating innate and cellular immune responses, alongside antibodies to conserved antigens." @default.
- W2890697983 created "2018-09-27" @default.
- W2890697983 creator A5002225868 @default.
- W2890697983 creator A5029973916 @default.
- W2890697983 creator A5077742706 @default.
- W2890697983 date "2018-09-08" @default.
- W2890697983 modified "2023-10-03" @default.
- W2890697983 title "Pneumococcal Vaccines: Host Interactions, Population Dynamics, and Design Principles" @default.
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