FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890706776> ?p ?o ?g. }

• W2890706776 endingPage "40" @default.
• W2890706776 startingPage "33" @default.
• W2890706776 abstract "Eosinophilic chronic rhinosinusitis (ECRS) is a subtype of chronic rhinosinusitis (CRS) that is characterized by intractable nasal polyp formation. Eosinophil-derived neurotoxin (EDN) is an eosinophil granule protein that is closely related to allergic inflammation, but the pathological implications of EDN in ECRS remain unknown. In this study, we evaluated the function of EDN in ECRS pathogenesis and assessed its potential as a disease activity marker. Serum EDN levels were significantly higher in patients with ECRS than in those with other nasal and paranasal diseases, and were positively correlated with clinical disease activity. Production of EDN from isolated human eosinophils was induced by stimulation with IL-5 in vitro. Human nasal epithelial cells were stimulated with EDN, and the resultant changes in gene expression were detected by RNA sequencing. Pathway analysis revealed that the major canonical pathway affected by EDN stimulation was ‘regulation of the epithelial–mesenchymal transition pathway’; the only gene in this pathway to be up-regulated was matrix metalloproteinase 9 (MMP-9). Consistent with this, immunostaining analysis revealed intense staining of both EDN and MMP-9 in nasal polyps from patients with ECRS. In conclusion, our data demonstrate that serum EDN level is a useful marker for the evaluation of ECRS severity. Furthermore, EDN induces production of MMP-9 from the nasal epithelium, which may be involved in the pathogenesis of ECRS." @default.
• W2890706776 created "2018-09-27" @default.
• W2890706776 creator A5002727514 @default.
• W2890706776 creator A5003474801 @default.
• W2890706776 creator A5014696875 @default.
• W2890706776 creator A5026633755 @default.
• W2890706776 creator A5028965157 @default.
• W2890706776 creator A5030855728 @default.
• W2890706776 creator A5035346649 @default.
• W2890706776 creator A5037169845 @default.
• W2890706776 creator A5040243658 @default.
• W2890706776 creator A5046856618 @default.
• W2890706776 creator A5048212731 @default.
• W2890706776 creator A5069159764 @default.
• W2890706776 creator A5077947438 @default.
• W2890706776 creator A5081499322 @default.
• W2890706776 creator A5083709357 @default.
• W2890706776 creator A5089114137 @default.
• W2890706776 creator A5090786965 @default.
• W2890706776 creator A5091861859 @default.
• W2890706776 date "2018-09-15" @default.
• W2890706776 modified "2023-10-16" @default.
• W2890706776 title "Eosinophil-derived neurotoxin enhances airway remodeling in eosinophilic chronic rhinosinusitis and correlates with disease severity" @default.
• W2890706776 cites W1533629006 @default.
• W2890706776 cites W1572269513 @default.
• W2890706776 cites W1885435857 @default.
• W2890706776 cites W1966533061 @default.
• W2890706776 cites W1978596588 @default.
• W2890706776 cites W1991046721 @default.
• W2890706776 cites W2013149735 @default.
• W2890706776 cites W2014968955 @default.
• W2890706776 cites W2021359366 @default.
• W2890706776 cites W2024758086 @default.
• W2890706776 cites W2033764116 @default.
• W2890706776 cites W2037836883 @default.
• W2890706776 cites W2056975585 @default.
• W2890706776 cites W2076934233 @default.
• W2890706776 cites W2083310288 @default.
• W2890706776 cites W2095311591 @default.
• W2890706776 cites W2102473788 @default.
• W2890706776 cites W2116547033 @default.
• W2890706776 cites W2134171178 @default.
• W2890706776 cites W2142554389 @default.
• W2890706776 cites W2143742516 @default.
• W2890706776 cites W2144082759 @default.
• W2890706776 cites W2151752998 @default.
• W2890706776 cites W2168515303 @default.
• W2890706776 cites W2171373028 @default.
• W2890706776 cites W2203885100 @default.
• W2890706776 cites W2426398535 @default.
• W2890706776 cites W2438233452 @default.
• W2890706776 cites W2746458373 @default.
• W2890706776 cites W2753902568 @default.
• W2890706776 cites W3183099619 @default.
• W2890706776 cites W4386008406 @default.
• W2890706776 doi "https://doi.org/10.1093/intimm/dxy061" @default.
• W2890706776 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6364622" @default.
• W2890706776 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30239772" @default.
• W2890706776 hasPublicationYear "2018" @default.
• W2890706776 type Work @default.
• W2890706776 sameAs 2890706776 @default.
• W2890706776 citedByCount "42" @default.
• W2890706776 countsByYear W28907067762019 @default.
• W2890706776 countsByYear W28907067762020 @default.
• W2890706776 countsByYear W28907067762021 @default.
• W2890706776 countsByYear W28907067762022 @default.
• W2890706776 countsByYear W28907067762023 @default.
• W2890706776 crossrefType "journal-article" @default.
• W2890706776 hasAuthorship W2890706776A5002727514 @default.
• W2890706776 hasAuthorship W2890706776A5003474801 @default.
• W2890706776 hasAuthorship W2890706776A5014696875 @default.
• W2890706776 hasAuthorship W2890706776A5026633755 @default.
• W2890706776 hasAuthorship W2890706776A5028965157 @default.
• W2890706776 hasAuthorship W2890706776A5030855728 @default.
• W2890706776 hasAuthorship W2890706776A5035346649 @default.
• W2890706776 hasAuthorship W2890706776A5037169845 @default.
• W2890706776 hasAuthorship W2890706776A5040243658 @default.
• W2890706776 hasAuthorship W2890706776A5046856618 @default.
• W2890706776 hasAuthorship W2890706776A5048212731 @default.
• W2890706776 hasAuthorship W2890706776A5069159764 @default.
• W2890706776 hasAuthorship W2890706776A5077947438 @default.
• W2890706776 hasAuthorship W2890706776A5081499322 @default.
• W2890706776 hasAuthorship W2890706776A5083709357 @default.
• W2890706776 hasAuthorship W2890706776A5089114137 @default.
• W2890706776 hasAuthorship W2890706776A5090786965 @default.
• W2890706776 hasAuthorship W2890706776A5091861859 @default.
• W2890706776 hasBestOaLocation W28907067761 @default.
• W2890706776 hasConcept C109523444 @default.
• W2890706776 hasConcept C126322002 @default.
• W2890706776 hasConcept C142724271 @default.
• W2890706776 hasConcept C203014093 @default.
• W2890706776 hasConcept C2776042228 @default.
• W2890706776 hasConcept C2777037409 @default.
• W2890706776 hasConcept C2777129736 @default.
• W2890706776 hasConcept C2779758542 @default.
• W2890706776 hasConcept C2780942790 @default.
• W2890706776 hasConcept C2781390199 @default.
• W2890706776 hasConcept C71924100 @default.

• next