FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890714582> ?p ?o ?g. }

• W2890714582 endingPage "418" @default.
• W2890714582 startingPage "412" @default.
• W2890714582 abstract "Aims To analyze the role of serum miR-125b-5p in reflecting liver damage and predicting outcomes in chronic hepatitis B (CHB) patients with acute-on-chronic liver failure (ACLF). Methods CHB patients with normal hepatic function (n = 100), moderate-to-severe liver damage (n = 90), and ACLF (n = 136) were included. Among hepatitis B virus (HBV)-ACLF patients, 86 and 50 were in the training and validation cohorts, respectively. Serum miR-125b-5p level was measured by quantitative real-time PCR. Results Serum miR-125b-5p level increased with disease progression, and serum miR-125b-5p level was lower in surviving than in dead HBV-ACLF patients. Among HBV-ACLF patients, miR-125b-5p positively correlated with total bilirubin (TBil; r = 0.214, p < 0.05) and model for end-stage liver disease (MELD) score (r = 0.382, p < 0.001) and negatively correlated with prothrombin activity(PTA; r = −0.215, p < 0.05). MiR-122 showed a contrasting performance compared with miR-125b-5p. Cox regression analysis showed that miR-125b-5p, miR-122, and PTA were independent survival predictors for HBV-ACLF, and low miR-125b-5p and high miR-122 levels may predict a longer survival in HBV-ACLF. MiR-125b-5p (AUC = 0.814) had a higher performance for survival prediction in HBV-ACLF compared with miR-122 (AUC = 0.804), PTA (AUC = 0.762), MELD score (AUC = 0.799), and TBil (AUC = 0.670) alone; predictive effectiveness of miR-125b-5p was increased by combination with miR-122 (AUC = 0.898). MiR-125b-5p was an effective predictor of HBV-ACLF outcomes in the validation cohort. Conclusions MiR-125b-5p increase is associated with severity of liver damage; high serum miR-125b-5p may serve as a predictor for poor outcomes in HBV-ACLF cases." @default.
• W2890714582 created "2018-09-27" @default.
• W2890714582 creator A5006234538 @default.
• W2890714582 creator A5014268039 @default.
• W2890714582 creator A5033469589 @default.
• W2890714582 creator A5041956749 @default.
• W2890714582 creator A5042489662 @default.
• W2890714582 creator A5061992559 @default.
• W2890714582 creator A5069380691 @default.
• W2890714582 creator A5088829662 @default.
• W2890714582 date "2019-03-01" @default.
• W2890714582 modified "2023-10-18" @default.
• W2890714582 title "Quantification of circulating miR-125b-5p predicts survival in chronic hepatitis B patients with acute-on-chronic liver failure" @default.
• W2890714582 cites W1518803705 @default.
• W2890714582 cites W1968419023 @default.
• W2890714582 cites W1969188594 @default.
• W2890714582 cites W1983932066 @default.
• W2890714582 cites W1988249627 @default.
• W2890714582 cites W1992398113 @default.
• W2890714582 cites W1998404710 @default.
• W2890714582 cites W2011471632 @default.
• W2890714582 cites W2053549862 @default.
• W2890714582 cites W2067012955 @default.
• W2890714582 cites W2097233439 @default.
• W2890714582 cites W2100097286 @default.
• W2890714582 cites W2111368337 @default.
• W2890714582 cites W2111848990 @default.
• W2890714582 cites W2113546559 @default.
• W2890714582 cites W2115093090 @default.
• W2890714582 cites W2132419064 @default.
• W2890714582 cites W2145818453 @default.
• W2890714582 cites W2251812724 @default.
• W2890714582 cites W2339717918 @default.
• W2890714582 cites W2396212421 @default.
• W2890714582 cites W2470689694 @default.
• W2890714582 cites W2561909042 @default.
• W2890714582 cites W2592188106 @default.
• W2890714582 cites W2594551614 @default.
• W2890714582 cites W2672058867 @default.
• W2890714582 cites W2746086542 @default.
• W2890714582 cites W2771836521 @default.
• W2890714582 cites W2781561500 @default.
• W2890714582 doi "https://doi.org/10.1016/j.dld.2018.08.030" @default.
• W2890714582 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30274791" @default.
• W2890714582 hasPublicationYear "2019" @default.
• W2890714582 type Work @default.
• W2890714582 sameAs 2890714582 @default.
• W2890714582 citedByCount "13" @default.
• W2890714582 countsByYear W28907145822019 @default.
• W2890714582 countsByYear W28907145822020 @default.
• W2890714582 countsByYear W28907145822021 @default.
• W2890714582 countsByYear W28907145822022 @default.
• W2890714582 countsByYear W28907145822023 @default.
• W2890714582 crossrefType "journal-article" @default.
• W2890714582 hasAuthorship W2890714582A5006234538 @default.
• W2890714582 hasAuthorship W2890714582A5014268039 @default.
• W2890714582 hasAuthorship W2890714582A5033469589 @default.
• W2890714582 hasAuthorship W2890714582A5041956749 @default.
• W2890714582 hasAuthorship W2890714582A5042489662 @default.
• W2890714582 hasAuthorship W2890714582A5061992559 @default.
• W2890714582 hasAuthorship W2890714582A5069380691 @default.
• W2890714582 hasAuthorship W2890714582A5088829662 @default.
• W2890714582 hasConcept C126322002 @default.
• W2890714582 hasConcept C203014093 @default.
• W2890714582 hasConcept C2522874641 @default.
• W2890714582 hasConcept C2777075537 @default.
• W2890714582 hasConcept C2777382497 @default.
• W2890714582 hasConcept C2777513400 @default.
• W2890714582 hasConcept C2780434524 @default.
• W2890714582 hasConcept C2780593183 @default.
• W2890714582 hasConcept C2992208098 @default.
• W2890714582 hasConcept C3020491458 @default.
• W2890714582 hasConcept C50382708 @default.
• W2890714582 hasConcept C71924100 @default.
• W2890714582 hasConcept C76318530 @default.
• W2890714582 hasConcept C90924648 @default.
• W2890714582 hasConceptScore W2890714582C126322002 @default.
• W2890714582 hasConceptScore W2890714582C203014093 @default.
• W2890714582 hasConceptScore W2890714582C2522874641 @default.
• W2890714582 hasConceptScore W2890714582C2777075537 @default.
• W2890714582 hasConceptScore W2890714582C2777382497 @default.
• W2890714582 hasConceptScore W2890714582C2777513400 @default.
• W2890714582 hasConceptScore W2890714582C2780434524 @default.
• W2890714582 hasConceptScore W2890714582C2780593183 @default.
• W2890714582 hasConceptScore W2890714582C2992208098 @default.
• W2890714582 hasConceptScore W2890714582C3020491458 @default.
• W2890714582 hasConceptScore W2890714582C50382708 @default.
• W2890714582 hasConceptScore W2890714582C71924100 @default.
• W2890714582 hasConceptScore W2890714582C76318530 @default.
• W2890714582 hasConceptScore W2890714582C90924648 @default.
• W2890714582 hasFunder F4320321001 @default.
• W2890714582 hasIssue "3" @default.
• W2890714582 hasLocation W28907145821 @default.
• W2890714582 hasLocation W28907145822 @default.
• W2890714582 hasOpenAccess W2890714582 @default.
• W2890714582 hasPrimaryLocation W28907145821 @default.
• W2890714582 hasRelatedWork W2079281353 @default.
• W2890714582 hasRelatedWork W2354581436 @default.

• next