FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890714611> ?p ?o ?g. }

• W2890714611 abstract "Bats are the only mammals capable of true, powered flight, which drives an extremely high metabolic rate. The Free Radical Theory of Ageing (FTRA) posits that a high metabolic rate causes mitochondrial heteroplasmy and the progressive ageing phenotype. Contrary to this, bats are the longest-lived order of mammals given their small size and high metabolic rate. To investigate if bats exhibit increased mitochondrial heteroplasmy with age, we performed targeted, deep sequencing of mitogenomes and measured point heteroplasmy in wild, long lived Myotis myotis. Blood was sampled from 195 individuals, aged between <1 and at 6+ years old, and whole mitochondria deep-sequenced, with a subset sampled over multiple years. The majority of heteroplasmies were at a low frequency and were transitions. Oxidative mutations were present in only a small number of individuals, suggesting local oxidative stress events. Cohort data showed no significant increase in heteroplasmy with age, while longitudinal data from recaptured individuals showed heteroplasmy is dynamic, and does not increase uniformly over time. We show that bats do not suffer from the predicted, inevitable increase in heteroplasmy as posited by the FRTA, instead heteroplasmy was found to be dynamic, questioning its presumed role as a primary driver of ageing." @default.
• W2890714611 created "2018-09-27" @default.
• W2890714611 creator A5004139548 @default.
• W2890714611 creator A5006062847 @default.
• W2890714611 creator A5020127292 @default.
• W2890714611 creator A5045559049 @default.
• W2890714611 creator A5045992372 @default.
• W2890714611 creator A5052525544 @default.
• W2890714611 date "2018-09-11" @default.
• W2890714611 modified "2023-10-03" @default.
• W2890714611 title "Population level mitogenomics of long-lived bats reveals dynamic heteroplasmy and challenges the Free Radical Theory of Ageing" @default.
• W2890714611 cites W1513618424 @default.
• W2890714611 cites W1539345444 @default.
• W2890714611 cites W1560829027 @default.
• W2890714611 cites W1701914422 @default.
• W2890714611 cites W1792718864 @default.
• W2890714611 cites W1815297412 @default.
• W2890714611 cites W1929484410 @default.
• W2890714611 cites W1951724000 @default.
• W2890714611 cites W1964807436 @default.
• W2890714611 cites W1965713319 @default.
• W2890714611 cites W1968458420 @default.
• W2890714611 cites W1969401957 @default.
• W2890714611 cites W1982141081 @default.
• W2890714611 cites W1983903377 @default.
• W2890714611 cites W1997655974 @default.
• W2890714611 cites W1998871189 @default.
• W2890714611 cites W2003691503 @default.
• W2890714611 cites W2004087775 @default.
• W2890714611 cites W2004860599 @default.
• W2890714611 cites W2005520835 @default.
• W2890714611 cites W2008744741 @default.
• W2890714611 cites W2017275974 @default.
• W2890714611 cites W2020439255 @default.
• W2890714611 cites W2021612469 @default.
• W2890714611 cites W2023552355 @default.
• W2890714611 cites W2024405748 @default.
• W2890714611 cites W2025097949 @default.
• W2890714611 cites W2027228430 @default.
• W2890714611 cites W2036897871 @default.
• W2890714611 cites W2040151712 @default.
• W2890714611 cites W2042594196 @default.
• W2890714611 cites W2050500616 @default.
• W2890714611 cites W2053379890 @default.
• W2890714611 cites W2059494962 @default.
• W2890714611 cites W2059884214 @default.
• W2890714611 cites W2070477670 @default.
• W2890714611 cites W2079092251 @default.
• W2890714611 cites W2080601544 @default.
• W2890714611 cites W2083718982 @default.
• W2890714611 cites W2088995367 @default.
• W2890714611 cites W2089335658 @default.
• W2890714611 cites W2093897311 @default.
• W2890714611 cites W2094048117 @default.
• W2890714611 cites W2094908805 @default.
• W2890714611 cites W2098428536 @default.
• W2890714611 cites W2101802274 @default.
• W2890714611 cites W2102445981 @default.
• W2890714611 cites W2102653023 @default.
• W2890714611 cites W2103503670 @default.
• W2890714611 cites W2107322686 @default.
• W2890714611 cites W2108234281 @default.
• W2890714611 cites W2109539269 @default.
• W2890714611 cites W2109920062 @default.
• W2890714611 cites W2111976489 @default.
• W2890714611 cites W2114806766 @default.
• W2890714611 cites W2115230740 @default.
• W2890714611 cites W2126948011 @default.
• W2890714611 cites W2128733166 @default.
• W2890714611 cites W2129711736 @default.
• W2890714611 cites W2132967521 @default.
• W2890714611 cites W2136811494 @default.
• W2890714611 cites W2139153938 @default.
• W2890714611 cites W2146325659 @default.
• W2890714611 cites W2155943701 @default.
• W2890714611 cites W2156195087 @default.
• W2890714611 cites W2160925215 @default.
• W2890714611 cites W2168133698 @default.
• W2890714611 cites W2174968744 @default.
• W2890714611 cites W2185141333 @default.
• W2890714611 cites W2215582843 @default.
• W2890714611 cites W2287025468 @default.
• W2890714611 cites W2291101007 @default.
• W2890714611 cites W2315512556 @default.
• W2890714611 cites W2344994267 @default.
• W2890714611 cites W2462516771 @default.
• W2890714611 cites W2544198093 @default.
• W2890714611 cites W2546215880 @default.
• W2890714611 cites W2549405014 @default.
• W2890714611 cites W2554533082 @default.
• W2890714611 cites W2567648404 @default.
• W2890714611 cites W4298872162 @default.
• W2890714611 doi "https://doi.org/10.1038/s41598-018-31093-2" @default.
• W2890714611 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6134106" @default.
• W2890714611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30206380" @default.
• W2890714611 hasPublicationYear "2018" @default.
• W2890714611 type Work @default.
• W2890714611 sameAs 2890714611 @default.
• W2890714611 citedByCount "23" @default.
• W2890714611 countsByYear W28907146112019 @default.

• next