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- W2890719327 abstract "e15656 Background: Neuroendocrine tumors (NETs) are considered rare tumors and can produce a variety of hormones. In this study, we examined the epidemiology and prognostic factors for NETs, in Italy. Methods: The Italian Association of Cancer Registries (AIRTUM) were researched to identify NETs: 38/39 cancer registries participated for the period 1976-2010. Malignant infiltrating tumors were included with the following morphology codes: 8150-8157, 8240-8246 and 8249. Results: We identified 9,707 patients with NETs: 55% males; 61% in the age 50-74 years, 17.5% under 50 years and 21.5 % in the 75+. We observed a significant increase in the reported annual age-adjusted incidence from 1976 (0.7/100,000) to 2010 (5.3/100,000). The highest rate was recorded in northern Italy (Milan 5.8/100,000), the lowest in southern Italy (Ragusa 0,81/100,000). The distribution of the tumor site was: lung 32.8%, small intestine 14.4%, colon 10.7%, stomach 8.8%, rectum 4.7%, breast 1.4%, other sites 20.3% and in 6.9% the primary site was unknown. Overall we found 2033 second tumors: 29 NETs and 2004 other sites: these were divided into before (1,360, 68%), and after (644, 22%) diagnosis of NETs. Among after diagnosis, we separate the synchronous within two months of diagnosis (78 cases, mainly lung 19% and colon 14%) by metachronous if diagnosed after two months of diagnosis (566 cases, mainly skin 18%, prostate12,5%, colon 8,5%, lung and bladder). Conclusions: We observed a increased reported incidence of NETs over time, suggesting that NETs are more prevalent than previously reported. Clinicians need to be become familiar with the natural history and patterns of disease progression, which are characteristics of these tumors. The association with second cancers should better direct the follow- up of patients with NETs ." @default.
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- W2890719327 date "2016-05-20" @default.
- W2890719327 modified "2023-10-16" @default.
- W2890719327 title "Variety of hormones produced by rare neuroendocrine tumors (NETs): Examination of epidemiology and prognostic factors for NETs in Italy." @default.
- W2890719327 doi "https://doi.org/10.1200/jco.2016.34.15_suppl.e15656" @default.
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